全文获取类型
收费全文 | 6109篇 |
免费 | 461篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 275篇 |
妇产科学 | 154篇 |
基础医学 | 995篇 |
口腔科学 | 165篇 |
临床医学 | 623篇 |
内科学 | 1152篇 |
皮肤病学 | 206篇 |
神经病学 | 581篇 |
特种医学 | 321篇 |
外科学 | 553篇 |
综合类 | 81篇 |
一般理论 | 3篇 |
预防医学 | 444篇 |
眼科学 | 112篇 |
药学 | 451篇 |
中国医学 | 45篇 |
肿瘤学 | 416篇 |
出版年
2023年 | 58篇 |
2022年 | 129篇 |
2021年 | 222篇 |
2020年 | 121篇 |
2019年 | 173篇 |
2018年 | 190篇 |
2017年 | 152篇 |
2016年 | 191篇 |
2015年 | 207篇 |
2014年 | 288篇 |
2013年 | 356篇 |
2012年 | 476篇 |
2011年 | 481篇 |
2010年 | 329篇 |
2009年 | 263篇 |
2008年 | 369篇 |
2007年 | 363篇 |
2006年 | 316篇 |
2005年 | 265篇 |
2004年 | 229篇 |
2003年 | 184篇 |
2002年 | 176篇 |
2001年 | 48篇 |
2000年 | 30篇 |
1999年 | 62篇 |
1998年 | 132篇 |
1997年 | 104篇 |
1996年 | 108篇 |
1995年 | 75篇 |
1994年 | 88篇 |
1993年 | 45篇 |
1992年 | 19篇 |
1991年 | 26篇 |
1990年 | 18篇 |
1989年 | 32篇 |
1988年 | 32篇 |
1987年 | 31篇 |
1986年 | 30篇 |
1985年 | 27篇 |
1984年 | 17篇 |
1983年 | 13篇 |
1982年 | 24篇 |
1981年 | 20篇 |
1980年 | 20篇 |
1979年 | 10篇 |
1978年 | 12篇 |
1977年 | 12篇 |
1976年 | 13篇 |
1975年 | 13篇 |
1974年 | 5篇 |
排序方式: 共有6627条查询结果,搜索用时 15 毫秒
51.
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter 总被引:12,自引:0,他引:12
Heinz A Braus DF Smolka MN Wrase J Puls I Hermann D Klein S Grüsser SM Flor H Schumann G Mann K Büchel C 《Nature neuroscience》2005,8(1):20-21
Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression. 相似文献
52.
53.
54.
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region 总被引:4,自引:0,他引:4
55.
Milan Macek Jr. Milan Macek Manfred Stuhrmann Eduard Kulovany Marie Dolanská Frantiek Koukolík Ingolf Boehm Jana Hronková Zdeka Jeková Magdalena Paulová Hana Martanová Jií Zach ré Reis Karl Sperling Jörg Schmidtke 《Clinical genetics》1991,39(3):219-222
The suspicion of prenatal meconium ileus syndrome was raised in a pregnancy in a family with no history of cystic fibrosis because of significantly higher maternal serum alpha-fetoprotein in the 16th and 19th week of gestation, dispersed areas with increased echogenity in the fetal abdomen, slight fetal ascites in the 24th-25th weeks of gestation, decreased amniotic fluid gamma-glutamyltranspeptidase (GGT) activity and alpha-fetoprotein level in the 25th-26th weeks, and normal 46,XY karotype of the fetus. The detection of a homozygous deltaF508 cystic fibrosis transmembrane regulator (CFTR) gene mutation, by means of PCR from a small amount of white blood cells and urine sediment cells, substantiated the diagnosis of cystic fibrosis in a prematurely delivered boy in the 28th week of gestation. The repeated sweat test was unsuccessful. The autopsy examination confirmed the diagnosis of cystic fibrosis. Fetal meconium ileus syndrome was complicated by peritonitis and by formation of a meconium pseudocyst. Direct PCR typing improves postnatal diagnostic possibilities in the early neonatal period in prematurely delivered babies when the sweat test is difficult to perform. 相似文献
56.
Posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) in families of adolescent childhood cancer survivors 总被引:7,自引:0,他引:7
Kazak AE Alderfer M Rourke MT Simms S Streisand R Grossman JR 《Journal of pediatric psychology》2004,29(3):211-219
OBJECTIVE: To describe rates and concordance of posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) in adolescent childhood cancer survivors and their mothers and fathers. METHOD: Participants were 150 adolescent survivors of childhood cancer, 146 mothers, and 103 fathers who completed the Impact of Events Scale-Revised, the Posttraumatic Stress Disorder Reaction Index, and the PTSD module of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. RESULTS: PTSS are common in families of childhood cancer survivors. Parents reported more symptomatology than former patients. Mothers and fathers had relatively equal rates of current PTSD and levels of PTSS. Nearly 30% of mothers met diagnostic criteria since their child's diagnosis, with 13.7% currently experiencing PTSD. Nearly 20% of families had at least one parent with current PTSD. Ninety-nine percent of the sample had at least one family member reexperiencing symptoms. CONCLUSIONS: Both PTSD and PTSS help in understanding the experience of adolescent cancer survivors and their families. Within families of childhood cancer survivors, it is likely that some member may be experiencing treatable bothersome memories, arousal, or avoidance specific to the cancer experience. 相似文献
57.
Janać B Pesić V Peković S Rakić L Stojiljković M 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2005,165(3):402-406
The time-course of changes of basal and amphetamine (AMPH)-induced locomotor and stereotypic activities in adult male Wistar rats after a single ribavirin injection was studied. In the first set of experiments, 10, 20 or 30 mg ribavirin/kg body weight (b.w.) were injected i.p. to rats and their basal motor activities were recorded every 10 min for 2 h and compared with those of saline-treated controls. In the second set of experiments, the animals were pretreated with ribavirin and 20 min later i.p. injected with AMPH (1.5 mg/kg b.w.). The controls received AMPH 20 min after the saline injection. Motor activity was recorded after the first injection and until 120 min after AMPH administration. Ribavirin did not significantly affect the time-course of either basal locomotor or stereotypic activities. Pretreatment with any of the applied ribavirin doses decreased the AMPH-induced hyperlocomotor response. However, the most pronounced effect was observed with ribavirin doses of 20 mg/kg and 30 mg/kg when administered during the first 10 min and 30 min after the AMPH injection respectively. In contrast, the stereotypic activities of these animals were only slightly changed. These results indicate a different susceptibility of regions in the basal ganglia to ribavirin. 相似文献
58.
59.
M. Deckert-Schlüter Josef Marek Michael Šetlík Jana Marková E. Pakos Robert Fischer Otmar D. Wiestler 《Virchows Archiv : an international journal of pathology》1998,432(5):477-481
A 62-year-old woman presented with loss of memory and a mild hemiparesis. Neuroradiology demonstrated a left frontoparietal
tumour. Biopsy specimens of this lesion revealed intracerebral Hodgkin’s lymphoma, a diagnosis supported by immunohistochemical
reactions of the tumour cells for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of
the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or Epstein-Barr
virus infection was involved in the pathogenesis of this neoplasm. Lymphomas in the lung were detected 3 months later. Following
neurosurgical excision, radiotherapy, and chemotherapy, the patient had no evidence of Hodgkin’s disease after 13 months of
follow-up.
Received: 8 October 1997 / Accepted: 8 December 1997 相似文献
60.
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation 总被引:22,自引:1,他引:22
Marsh DJ; Coulon V; Lunetta KL; Rocca-Serra P; Dahia PL; Zheng Z; Liaw D; Caron S; Duboue B; Lin AY; Richardson AL; Bonnetblanc JM; Bressieux JM; Cabarrot-Moreau A; Chompret A; Demange L; Eeles RA; Yahanda AM; Fearon ER; Fricker JP; Gorlin RJ; Hodgson SV; Huson S; Lacombe D; Eng C 《Human molecular genetics》1998,7(3):507-515
The tumour suppressor gene PTEN , which maps to 10q23.3 and encodes a 403
amino acid dual specificity phosphatase (protein tyrosine phosphatase;
PTPase), was shown recently to play a broad role in human malignancy.
Somatic PTEN deletions and mutations were observed in sporadic breast,
brain, prostate and kidney cancer cell lines and in several primary tumours
such as endometrial carcinomas, malignant melanoma and thyroid tumours. In
addition, PTEN was identified as the susceptibility gene for two hamartoma
syndromes: Cowden disease (CD; MIM 158350) and Bannayan-Zonana (BZS) or
Ruvalcaba-Riley-Smith syndrome (MIM 153480). Constitutive DNA from 37 CD
families and seven BZS families was screened for germline PTEN mutations.
PTEN mutations were identified in 30 of 37 (81%) CD families, including
missense and nonsense point mutations, deletions, insertions, a
deletion/insertion and splice site mutations. These mutations were
scattered over the entire length of PTEN , with the exception of the first,
fourth and last exons. A 'hot spot' for PTEN mutation in CD was identified
in exon 5 that contains the PTPase core motif, with 13 of 30 (43%) CD
mutations identified in this exon. Seven of 30 (23%) were within the core
motif, the majority (five of seven) of which were missense mutations,
possibly pointing to the functional significance of this region. Germline
PTEN mutations were identified in four of seven (57%) BZS families studied.
Interestingly, none of these mutations was observed in the PTPase core
motif. It is also worthy of note that a single nonsense point mutation,
R233X, was observed in the germline DNA from two unrelated CD families and
one BZS family. Genotype-phenotype studies were not performed on this small
group of BZS families. However, genotype-phenotype analysis inthe group of
CD families revealed two possible associations worthy of follow-up in
independent analyses. The first was an association noted in the group of CD
families with breast disease. A correlation was observed between the
presence/absence of a PTEN mutation and the type of breast involvement
(unaffected versus benign versus malignant). Specifically and more
directly, an association was also observed between the presence of a PTEN
mutation and malignant breast disease. Secondly, there appeared to be an
interdependent association between mutations upstream and within the PTPase
core motif, the core motif containing the majority of missense mutations,
and the involvement of all major organ systems (central nervous system,
thyroid, breast, skin and gastrointestinal tract). However, these
observations would need to be confirmed by studying a larger number of CD
families.
相似文献