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Javeed Ahmad Tantray K. Pratap Reddy Kaiser Jamil Shiva Kumar Yerra 《Indian heart journal》2019,71(1)
Background
The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs. In the present study, we analyzed the impact of a genetic variant in CYP2J2 on coronary artery disease (CAD) in the Telangana region of Indian population.Material and methods
The case–control study consisted of 100 CAD cases and 110 healthy controls. The deoxyribonucleic acid was extracted using the salting out method. Genotyping and gene expression was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods.Results
In the present study, the percentage of smokers, alcoholics, hypertensive patients, and diabetics was high. Increase in fasting glucose, urea, creatinine, fasting triglycerides, total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), total cholesterol/high-density lipoprotein (TC/HDL), LDL/HDL, homocysteine, and C-reactive protein levels were significantly higher in patients with CAD than in controls (p < 0.001). CYP2J2 G-50T was associated with CAD (p = 0.04). The mRNA expression of CYP2J2 showed altered gene expression in this study among CAD patients in comparison with control (p = 0.01).Conclusions
A functionally relevant polymorphism of the CYP2J2 gene was independently associated with an increased risk of CAD. 相似文献24.
A Human Clinical,Histological, Histomorphometrical,and Radiographical Study on Biphasic HA‐Beta‐TCP 30/70 in Maxillary Sinus Augmentation 
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下载免费PDF全文 25.
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Sanjay Sinha Asra Khan Athar M. Qureshi William Suh Hillel Laks Jamil Aboulhosn Reshma Biniwale Iki Adachi Anisha Fernando Daniel Levi 《Catheterization and cardiovascular interventions》2020,95(2):253-261
- Diabetic patients are frequently affected by coronary artery disease (CAD) and are at increased risk of CAD‐related adverse events, even after drug‐eluting stent (DES) implantation. If currently available DES have similar safety and efficacy in diabetic and nondiabetic patients is still debated.
- This prospective, multicenter registry showed similar 3‐year outcome in patients undergoing different DES implantation, although diabetic patients, especially those requiring insulin treatment, had significantly higher risk of adverse events than nondiabetic patients.
- Specific efforts to improve the performance of DES in diabetic patients are mandatory to adequately address the unsolved issue of diabetic patients affected by CAD.
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Efficacy and safety of transulnar coronary angiography and interventions—A single center experience 下载免费PDF全文
下载免费PDF全文 Anand R. Deshmukh MD Manu Kaushik MD Ahmed Aboeata MBBCH Jamil Abuzetun MD Tammy L. Burns PHARMD Caroline A. Nubel BS Michael D. White MD FACC Thomas J. Lanspa MD FACC Claire B. Hunter MD FACC Aryan N. Mooss MD FACC Dennis J. Esterbrooks MD FACC 《Catheterization and cardiovascular interventions》2014,83(1):E26-E31
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Weiyi Tan Marcella Calfon Press Gentian Lluri Jamil Aboulhosn 《Catheterization and cardiovascular interventions》2020,96(2):384-388
Congenital heart disease patients, specifically with unbalanced atrioventricular septal defects and common atrioventricular valves requiring single ventricle palliation, have substantial morbidity and mortality. Atrioventricular valve regurgitation (AVVR) is associated with poor outcomes in single ventricle patients, and many of them require surgical treatment of AVVR in their lifetimes. We describe a unique case of transcatheter edge‐to‐edge valve repair using the MitraClip system (Abbott, Chicago, IL) in a single ventricle patient with severe common AVVR. 相似文献