全文获取类型
收费全文 | 826934篇 |
免费 | 38358篇 |
国内免费 | 1096篇 |
专业分类
耳鼻咽喉 | 9383篇 |
儿科学 | 26606篇 |
妇产科学 | 17763篇 |
基础医学 | 124885篇 |
口腔科学 | 16647篇 |
临床医学 | 73033篇 |
内科学 | 151185篇 |
皮肤病学 | 14190篇 |
神经病学 | 61324篇 |
特种医学 | 33446篇 |
外国民族医学 | 53篇 |
外科学 | 126660篇 |
综合类 | 11749篇 |
现状与发展 | 3篇 |
一般理论 | 279篇 |
预防医学 | 67799篇 |
眼科学 | 17297篇 |
药学 | 59647篇 |
3篇 | |
中国医学 | 1913篇 |
肿瘤学 | 52523篇 |
出版年
2021年 | 6349篇 |
2019年 | 6189篇 |
2018年 | 29577篇 |
2017年 | 22781篇 |
2016年 | 25712篇 |
2015年 | 8795篇 |
2014年 | 11696篇 |
2013年 | 17015篇 |
2012年 | 30617篇 |
2011年 | 46535篇 |
2010年 | 32916篇 |
2009年 | 24500篇 |
2008年 | 42409篇 |
2007年 | 46786篇 |
2006年 | 25588篇 |
2005年 | 26645篇 |
2004年 | 27130篇 |
2003年 | 26906篇 |
2002年 | 24512篇 |
2001年 | 23923篇 |
2000年 | 24358篇 |
1999年 | 20410篇 |
1998年 | 6987篇 |
1997年 | 5825篇 |
1996年 | 5679篇 |
1995年 | 5402篇 |
1992年 | 15269篇 |
1991年 | 16746篇 |
1990年 | 16802篇 |
1989年 | 16427篇 |
1988年 | 15102篇 |
1987年 | 14973篇 |
1986年 | 13951篇 |
1985年 | 13543篇 |
1984年 | 10305篇 |
1983年 | 8867篇 |
1982年 | 5295篇 |
1981年 | 4951篇 |
1979年 | 9558篇 |
1978年 | 7056篇 |
1977年 | 5744篇 |
1976年 | 6038篇 |
1975年 | 7095篇 |
1974年 | 7912篇 |
1973年 | 7599篇 |
1972年 | 6896篇 |
1971年 | 6618篇 |
1970年 | 6167篇 |
1969年 | 5689篇 |
1968年 | 5356篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
C. Dessinioti C.C. Zouboulis V. Bettoli D. Rigopoulos 《Journal of the European Academy of Dermatology and Venereology》2020,34(10):2229-2240
Guidelines and consensus on the management of patients with acne aim to give evidence-based, expert-group recommendations. This review compares current guidelines and consensus articles to provide a compilation of recommendations on the treatment of acne with oral isotretinoin. Ten common, relevant, clinical questions are addressed, based on published recommendations, including the indications of isotretinoin, the proposed daily dose, the cumulative isotretinoin dose and the laboratory monitoring needed. Recommendations on special considerations are also addressed, including the timing of procedures and the question of an association of depression or inflammatory bowel disease with isotretinoin. A major limitation is the use of different classification systems for acne across guidelines. The recommended daily dose ranges from 0.3 to 0.5 mg/kg in the European guidelines to up to 1 mg/kg in the US guidelines. A specific duration of treatment of at least 6 months is only recommended in the European guidelines. All guidelines report the need of strict pregnancy prevention measures. The European, French and US guidelines recommend to monitor for symptoms of depression. Important clinical questions that are inconsistently addressed in guidelines include the age indication, the recommendation for a cumulative dose, the timing of procedures, the association of isotretinoin with IBD, the recommendation for preventing acne flares and for appropriate laboratory monitoring. These topics should be clearly included in the recommendations of guidelines as they are often raised in everyday clinical practice. 相似文献
42.
43.
Marta Rozanski Valentin Neuhaus Emily Thornton Stéphanie J. E. Becker James P. Rathmell David Ring 《Journal of hand and microsurgery》2015,7(1):30-35
This study used the National Survey of Ambulatory Surgery (NSAS) database to measure the incidence of and risk factors for symptoms in the ambulatory surgery center and problems within 24 h after isolated carpal tunnel release (CTR). The NSAS contained records on 400,000 adult patients with carpal tunnel syndrome who were treated with CTR in 2006, based on ICD-9 codes. The type of anesthesia used and factors associated with symptoms and problems were sought in bivariate and multivariable statistical analyses. The mean duration of the procedure was 16 ± 8.8 min. Only 5 % were performed under local anesthesia without sedation, 45 % with IV sedation, 28 % regional anesthesia, and 19 % general anesthesia. Symptoms in the ambulatory surgery center or a problem within 24 h after discharge were recorded in 10 % of patients, all of them minor and transient, including difficulties with pain and its treatment. The strongest risk factors were male sex, age of 45 years and older, and participation of an anesthesiologist. Local anesthesia and regional anesthesia were associated with more perioperative symptoms and postoperative problems. Most CTR are performed with some sedation in the United States. CTR is a safe procedure: one in 10 patients will experience a minor issue in the perioperative or immediate postoperative period. 相似文献
44.
45.
46.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.
47.
48.
N. S. Hari Narayana Moorthy Sergio F. Sousa Maria J. Ramos Pedro A. Fernandes 《Medicinal chemistry research》2016,25(7):1340-1357
Farnesyltransferase (FTase) is one of the prenyltransferase family enzymes that catalyse the transfer of 15-membered isoprenoid (farnesyl) moiety to the cysteine of CAAX motif-containing proteins including Rho and Ras family of G proteins. Inhibitors of FTase act as drugs for cancer, malaria, progeria and other diseases. In the present investigation, we have developed two structure-based pharmacophore models from protein–ligand complex (3E33 and 3E37) obtained from the protein data bank. Molecular dynamics (MD) simulations were performed on the complexes, and different conformers of the same complex were generated. These conformers were undergone protein–ligand interaction fingerprint (PLIF) analysis, and the fingerprint bits have been used for structure-based pharmacophore model development. The PLIF results showed that Lys164, Tyr166, TrpB106 and TyrB361 are the major interacting residues in both the complexes. The RMSD and RMSF analyses on the MD-simulated systems showed that the absence of FPP in the complex 3E37 has significant effect in the conformational changes of the ligands. During this conformational change, some interactions between the protein and the ligands are lost, but regained after some simulations (after 2 ns). The structure-based pharmacophore models showed that the hydrophobic and acceptor contours are predominantly present in the models. The pharmacophore models were validated using reference compounds, which significantly identified as HITs with smaller RMSD values. The developed structure-based pharmacophore models are significant, and the methodology used in this study is novel from the existing methods (the original X-ray crystallographic coordination of the ligands is used for the model building). In our study, along with the original coordination of the ligand, different conformers of the same complex (protein–ligand) are used. It concluded that the developed methodology is significant for the virtual screening of novel molecules on different targets. 相似文献
49.
Stelter K. Theodoraki M. N. Becker S. Tsekmistrenko V. Olzowy B. Ledderose G. 《European archives of oto-rhino-laryngology》2015,272(3):639-639
European Archives of Oto-Rhino-Laryngology - 相似文献
50.
Paul J. Devlin Brian W. McCrindle James K. Kirklin Eugene H. Blackstone William M. DeCampli Christopher A. Caldarone Ali Dodge-Khatami Pirooz Eghtesady James M. Meza Peter J. Gruber Kristine J. Guleserian Bahaaladin Alsoufi Linda M. Lambert James E. OBrien Erle H. Austin Jeffrey P. Jacobs Tara Karamlou 《The Journal of thoracic and cardiovascular surgery》2019,157(2):684-695.e8