全文获取类型
收费全文 | 962篇 |
免费 | 40篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 31篇 |
妇产科学 | 5篇 |
基础医学 | 83篇 |
口腔科学 | 27篇 |
临床医学 | 92篇 |
内科学 | 188篇 |
皮肤病学 | 17篇 |
神经病学 | 33篇 |
特种医学 | 121篇 |
外科学 | 74篇 |
综合类 | 27篇 |
预防医学 | 45篇 |
眼科学 | 112篇 |
药学 | 53篇 |
中国医学 | 11篇 |
肿瘤学 | 95篇 |
出版年
2023年 | 13篇 |
2022年 | 27篇 |
2021年 | 31篇 |
2020年 | 12篇 |
2019年 | 27篇 |
2018年 | 20篇 |
2017年 | 15篇 |
2016年 | 25篇 |
2015年 | 19篇 |
2014年 | 49篇 |
2013年 | 47篇 |
2012年 | 54篇 |
2011年 | 46篇 |
2010年 | 40篇 |
2009年 | 36篇 |
2008年 | 41篇 |
2007年 | 43篇 |
2006年 | 28篇 |
2005年 | 40篇 |
2004年 | 30篇 |
2003年 | 28篇 |
2002年 | 21篇 |
2001年 | 19篇 |
2000年 | 16篇 |
1999年 | 20篇 |
1998年 | 27篇 |
1997年 | 19篇 |
1996年 | 14篇 |
1995年 | 18篇 |
1994年 | 13篇 |
1993年 | 15篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 20篇 |
1988年 | 16篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 14篇 |
1984年 | 3篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 9篇 |
1976年 | 6篇 |
1975年 | 8篇 |
1955年 | 2篇 |
1951年 | 1篇 |
排序方式: 共有1022条查询结果,搜索用时 15 毫秒
141.
Nima Jalali Gary M. Vilke Melissa Korenevsky Edward M. Castillo Michael P. Wilson 《The Journal of emergency medicine》2014
Background
Pain symptoms related to cardiac ischemia can vary greatly from patient to patient. However, should emergency physicians consider the possibility of myocardial infarction in patients who present solely with dental pain?Objective
This is a systematic review of the literature investigating the incidence of jaw, tooth, or facial pain as the sole symptom of cardiac ischemia.Methods
Studies investigating jaw, tooth, or facial pain of cardiac origin were identified using the PubMed database. All English studies in which cardiac pain originated in the face, teeth, or jaw were screened for inclusion. Data were abstracted from each study utilizing a structured review process, and rated for methodological quality.Results
Eighteen studies met study criteria: 16 were case reports, and the remaining 2 were prospective cohort studies. After quality assessment and categorization, nine reports were categorized as weak, eight moderate, and one strong methodological quality.Conclusion
Cardiac ischemia may present in no anatomic location other than face or jaw. However, despite frequent claims in the literature to the contrary, the lack of methodological quality of the studies investigated impedes a firm conclusion of face, jaw, or tooth pain as the only symptom of cardiac insufficiency. 相似文献142.
143.
The clearance of vancomycin is significantly reduced in patients with acute, as well as, chronic renal failure. Although multiple-dosage regimen adjustment techniques have been proposed for these patients, there is little quantitative data to guide the individualization of vancomycin therapy in acute renal failure patients who are receiving continuous renal replacement therapy (CRRT). To determine appropriate vancomycin dosing strategies for patients receiving continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodialysis (CVVHD), we performed controlled clearance studies in five stable hemodialysis patients with three hemofilters: an acrylonitrile copolymer 0.6 m2 (AN69), polymethylmethacrylate 2.1 m2 (PMMA), and polysulfone 0.65 m2 (PS). Patients received 500 mg of vancomycin intravenously at least 12 hours before the start of the clearance study. The concentration of vancomycin in multiple plasma and dialysate/ultrafiltrate samples was determined by EMIT (Syva, Palo Alto, CA). The diffusional clearance and sieving coefficient (SC) of vancomycin were compared by a mixed-model repeated-measures analysis of variance (ANOVA) with filter and blood (Q(B)), dialysate inflow (Q(DI)), or ultrafiltration rate (Q(UF)) as the main effects and patient as a random effect. Vancomycin was moderately protein bound in these patients; free fraction ranged from 49% to 83%. The SCs of the three filters were similar and significantly correlated with the free fraction of vancomycin (P = 0.01; r2 = 0.465). Significant linear relationships were observed between the diffusional clearance of vancomycin and Q(DI) for all three filters: AN69 (slope = 0.482; r2 = 0.880); PMMA (slope = 0.853; r2 = 0.966); and PS (slope = 0.658; r2 = 0.887). The slope of this relationship for the PMMA filter was significantly greater than that of the AN69 and PS filters. The clearance of vancomycin, urea, and creatinine, however, was essentially constant at all Q(B)s for all three filters. Thus, the clearance of vancomycin was not membrane dependent during CVVH. However, during CVVHD, membrane dependence of vancomycin clearance was noted at a Q(DI) greater than 16.7 mL/min; vancomycin clearance with PMMA at a Q(DI) of 25 mL/min was 66% and 43% greater than that with the AN69 and PS filters, respectively. CVVH (62% to 262%) and CVVHD (90% to 540%) can significantly augment the clearance of vancomycin in acute renal failure patients. Dosing strategies for individualization of vancomycin therapy in patients receiving CVVH and CVVHD are proposed. 相似文献
144.
Diverticular abscesses: percutaneous drainage 总被引:7,自引:0,他引:7
Neff CC; vanSonnenberg E; Casola G; Wittich GR; Hoyt DB; Halasz NA; Martini DJ 《Radiology》1987,163(1):15-18
Percutaneous catheter drainage was performed in 16 patients with diverticulitis complicated by abscesses. Each patient had resolution of fever within 72 hours. Eleven patients subsequently underwent simultaneous sigmoid resection and operative anastomosis 10-40 days after percutaneous drainage. One patient required a three-stage procedure after percutaneous drainage, and one patient was too unstable for operation at any time during her course and eventually died of respiratory failure. Three patients did not undergo resection after catheter drainage and have remained asymptomatic for 1-2 1/2 years. Ten of 16 patients had fistulas, eight of which closed spontaneously. Experience with percutaneous drainage of diverticular abscesses suggests that it obviates surgical abscess drainage and permits a single operation (sigmoid resection and closure) to be performed safely. Percutaneous abscess drainage has cost-saving implications, since one or two operations may be avoided in most patients, and in some high-risk elderly patients all operations may be obviated. 相似文献
145.
Adenosine dialdehyde and nitrous oxide, specific S-adeno- sylhomocysteine hydrolase and methionine synthetase inhibitors, respectively, induced differentiation of the human promyelocytic cell line HL-60. Their effect did not appear to be mediated through changes in transmethylation or decreased S-adenosylmethionine synthesis because (1) there was little correlation between the concentrations of adenosine dialdehyde that induced differentiation and those that changed the ratio of the intracellular concentrations of S- adenosylmethionine to S-adenosylhomocysteine, and (2) inhibition of methionine adenosyltransferase by cycloleucine did not induce differentiation. The differentiation induced by adenosine dialdehyde was prevented by homocysteine and that by nitrous oxide was inversely related to the medium methionine concentration. This suggested that differentiation was secondary to decreased methionine synthesis. 相似文献
146.
147.
Henry DA; Corcoran HL; Lewis TD; Barnhart GR; Szentpetery S; Lower RR 《Radiology》1989,170(2):343-350
As cardiac transplantation has become widely available, computed tomography (CT) of the chest has played a useful role in the examination of patients after heart transplantation. To determine anatomic features related to the procedure, the authors evaluated 59 scans in 46 patients who had undergone orthotopic cardiac transplantation. Aortic anastomosis (seen in 98% of scans) and altered spacing between the great vessels (83%) proved to be the most common and most reliable findings. Other features including atrial anastomosis, high main pulmonary artery segment, remnant superior vena cava, and cardiac reorientation were also seen. Accurate interpretation of adenopathy, mediastinal abscess, and pericardial effusion will be enhanced in these patients through a better understanding of the cardiovascular-pericardial complex, which is afforded by CT. 相似文献
148.
149.
Materials and methods A 7-year-old boy diagnosed with Duchenne muscular dystrophy (DMD) presented with clinical features of raised intracranial
tension. A CT scan revealed an enhancing vermian mass extending on to the fourth ventricle, which was excised and reported
to be medulloblastoma. The patient was treated with craniospinal radiotherapy but progressed after 6 months.
Discussion Neoplasms associated with DMD are rare and the present case may well be the first one with medulloblastoma. Interestingly,
all neoplasms associated with DMD reported so far have been round cell tumors, which may lead to insights into their possible
molecular associations. 相似文献
150.
David A. Clark Petra C. Arck Reza Jalali Fatima S. Merali Justin Manuel Gerard Chaouat Jennifer L. Underwood James F. Mowbray 《American journal of reproductive immunology (New York, N.Y. : 1989)》1996,35(4):330-337
PROBLEM: Some mammalian pregnancy failure is thought to occur by immunological or immunologically modifiable mechanisms. The original model wherein spontaneous abortion was proposed to represent rejection of the conceptus as an allograft has been supplanted by a model of maternal paraimmunological natural effector cell toxicity to fetal trophoblast more closely related to tumor rejection. The problem is to integrate current information concerning the role of immunological, paraimmunological, endocrinological, and stress-triggered neural factors that determine whether or not abortion will occur. METHODS: Review of existing data. RESULTS: An integrated model is proposed. CONCLUSION: Immunological factors play an important role in abortion processes and prevention of abortions. The existence of abortogenic mechanisms and their regulation appears to be based upon optimizing survival of the species. Two new conceptual models provide a useful framework for further investigation of human pregnancy failure and its treatment. 相似文献