Functional incapacity among low-income elderly women

The scope of this study was to analyze the relationship between socio-demographic and health-related aspects and functional incapacity among low-income elderly women. This cross-sectional study involved a representative sample of 222 women with mean age of 70 years (± 7.27), in community groups in the city of Jequié, in the State of Bahia, Brazil. Anthropometric measurements were taken and interviews staged to examine the socio-demographic, physical and behavioral health variables. The statistical analysis was accomplished with a level of significance of p<0.05, with calculation of the respective odds ratio in the binary logistic regression, for analysis of hierarchically-grouped factors. The prevalence of functional incapacity was 46.8% and, by using hierarchical multivariate analysis, a significant association was detected with increased age, insufficient schooling, hospitalization, lack of physical exercise throughout life and alterations in the cognitive function. The characteristics identified that associated limitations in instrumental activities in daily life suggest a complex causal network in the determination of functional incapacity in low-income elderly women.     

The role of hippocampus in the pathophysiology of bipolar disorder

Bipolar disorder (BD) is thought to be associated with abnormalities within discrete brain regions associated with emotional regulation, particularly in fronto-limbic-subcortical circuits. Several reviews have addressed the involvement of the prefrontal cortex in the pathophysiology of BD, whereas little attention has been given to the role of the hippocampus. This study critically reviews data from brain imaging, postmortem, neuropsychological, and preclinical studies, which suggested hippocampal abnormalities in BD. Most of the structural brain imaging studies did not find changes in hippocampal volume in BD, although a few studies suggested that anatomical changes might be restricted to the psychotic, pediatric, or unmedicated BD subgroups. Functional imaging studies showed abnormal brain activation in the hippocampus and its closely related regions during emotional, attentional, and memory tasks. This is consistent with neuropsychological findings that revealed a wide range of cognitive disturbances during acute mood episodes and a significant impairment in declarative memory during remission. Postmortem studies indicate abnormal glutamate and GABA transmission in the hippocampus of BD patients, whereas data from preclinical studies suggest that the regulation of hippocampal plasticity and survival might be associated with the therapeutic effects of mood stabilizers. In conclusion, the available evidence suggests that the hippocampus plays an important role in the pathophysiology of BD.     

Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia

BACKGROUND: Although memory deficits are consistently reported in schizophrenia and bipolar disorder, the mechanisms underlying these impairments are poorly understood. Clarifying the nature and degree of overlap in memory deficits between the two illnesses could help to distinguish brain systems disrupted in these illnesses, and indicate cognitive remediation strategies to improve patient outcomes. METHOD: We examined performance on a non-verbal memory task in clinically stable out-patients with bipolar disorder (n=40), schizophrenia (n=40), and healthy comparison subjects (n=40). This task includes conditions in which distinct mnemonic strategies -- namely, using context to organize familiar stimuli or using holistic representation of novel stimuli -- facilitate performance. RESULT: When compared to a reference condition, bipolar patients had deficits consistent with organizational dysfunction and poor detection of novel information. Although patients with schizophrenia performed worse than the other groups, they were only differentially impaired when organizational demands were significant. Task performance was not correlated with severity of clinical symptomatology. CONCLUSIONS: This pattern of distinct memory impairments implies disturbances in partially overlapping neural systems in bipolar disorder and schizophrenia. Evidence of impairment in detection of novel stimuli that is unique to bipolar disorder suggests that, while the absolute level of cognitive dysfunction is less severe in bipolar disorder as compared to schizophrenia, subtle disruptions in memory are present. These findings can be used to plan targeted cognitive remediation programs by helping patients to capitalize on intact functions and to learn new strategies that they do not employ without training.     

Reduced educational attainment in bipolar disorder

OBJECTIVE: To document educational attainment in relation to IQ in patients with bipolar disorder, in order to establish guidelines for matching patients with appropriate comparison subjects. METHOD: 60 adult patients with bipolar disorder were compared to 60 demographically matched healthy subjects on IQ measures and educational attainment. RESULTS: Despite comparable IQ levels, patients with bipolar disorder completed fewer years of education than controls. Although over 60% of both groups entered college, only 16% of bipolar patients received a college degree. In contrast 47% of the comparison sample completed college. Educational attainment did not differ between subgroups of patients with earlier vs. later illness onset, nor as a function of comorbid substance abuse. LIMITATIONS: Other comorbidities, such as anxiety disorders or sub-clinical symptomatology prior to illness onset, were not assessed. CONCLUSIONS: Educational attainment is disrupted in bipolar disorder, and thus should not be used for matching patients and comparison subjects. Reduced educational attainment may contribute to later functional disability in this illness.