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Kienesberger S Perez-Perez GI Rivera-Correa JL Tosado-Acevedo R Li H Dubois A Gonzalez-Martinez JA Dominguez Bello MG Blaser MJ 《Gut pathogens》2012,4(1):9
ABSTRACT: BACKGROUND: Helicobacter pylori are successful colonizers of the human gastric mucosa. Colonization increases the risk of peptic ulcer disease and adenocarcinoma. However, potential benefits of H. pylori colonization include protection against early-onset asthma and against gastrointestinal infections. Campylobacter jejuni are a leading cause of bacterial diarrhea and complications include Guillain-Barre syndrome. Here, we describe the development of reliable serological assays to detect antibodies against those two bacteria in Rhesus macaques and investigated their distribution within a social group of monkeys. METHODS: Two cohorts of monkeys were analyzed. The first cohort consisted of 30 monkeys and was used to establish an enzyme-linked immunosorbent assay (ELISA) for H. pylori antibodies detection. To evaluate colonization of those macaques, stomach biopsies were collected and analyzed for the presence of H. pylori by histology and culture. C. jejuni ELISAs were established using human serum with known C. jejuni antibody status. Next, plasma samples of the 89 macaques (cohort 2) were assayed for antibodies and then statistically analyzed. RESULTS: An H. pylori IgG ELISA, which was 100% specific and 93% sensitive, was established. In contrast, the IgA ELISA was only 82% specific and 61% sensitive. The CagA IgG assay was 100% sensitive and 61% of the macaques were positive. In cohort 2, 62% macaques were H. pylori sero-positive and 52% were CagA positive. The prevalence of H. pylori IgG and CagA IgG increased with monkey age as described for humans. Of the 89 macaques 52% showed IgG against C. jejuni but in contrast to H. pylori, the sero-prevalence was not associated with increasing age. However, there was a drop in the IgG (but not in IgA) mean values between infant and juvenile macaques, similar to trends described in humans. CONCLUSIONS: Rhesus macaques have widespread exposure to H. pylori and C. jejuni, reflecting their social conditions and implying that Rhesus macaques might provide a model to study effects of these two important human mucosal bacteria on a population. 相似文献
993.
The present study examined various factors from the interactive and sociocultural models of bulimia nervosa as predictors of the onset of compensatory behaviors. Participants (n = 237) completed a series of questionnaires assessing dietary restraint, body dissatisfaction, negative affect, binge eating, perfectionism, and self-esteem at two time points one year apart. Women who did not engage in compensatory behaviors at time one but did engage in compensatory behaviors at time two (n = 21) were compared to women who engaged in compensatory behaviors at both time points (n = 28) and women who did not engage in compensatory behaviors at either time point (n = 188). Body dissatisfaction and perfectionism at time one significantly predicted women who began using compensatory behaviors compared to women who did not engage in compensatory behaviors at either time point. Women who experienced an onset of compensatory behaviors also reported significantly greater body dissatisfaction at time 1 than women who engaged in compensatory behaviors for the duration of the study. Implications and limitations of these findings are discussed. 相似文献
994.
Harmful alcohol consumption amongst Pacific people (those of Polynesian descent) is recognized as a public health priority in New Zealand, yet little epidemiological information exists on this pattern of drinking. Using a large birth cohort study, which includes the mother, father and child triad, this study aims to determine the prevalence and change in any harmful drinking levels prenatally, antenatally and in the postpartum period for mothers and fathers, and to measure the concordance of both partners' reports of that drinking in an ethnically representative sample of Pacific families within New Zealand. Participants were selected from births where at least one parent was identified as being of Pacific ethnicity and a New Zealand permanent resident (1376 mothers and 825 fathers at baseline); many of whom are young to middle aged adults. These participants have been prospectively followed-up multiple times since. The Alcohol Use Disorders Identification Test consumption questions (AUDIT-C) were used over successive measurement waves to define any and harmful drinking levels. Recommended screening thresholds were employed. Longitudinal analyses on complete cases and imputed data, accounting for differential attrition, were undertaken and reported. Clear temporal patterns of alcohol consumption emerged for both mothers and fathers, together with significant and important ethnic differences. Moreover, there was considerable movement in alcohol consumption categories between consecutive measurement waves for both mothers and fathers. Among couples, there was significant asymmetry in drinking patterns and poor statistical agreement. However, 9.1% (14.1% in imputed analyses) of Pacific children aged 2 years had both parents indicated for harmful drinking. The significant important heterogeneity and ethnic differences suggest that both ethnic-specific and pan-Pacific interventions and prevention strategies are likely needed for successful interventions. More emphasis should be placed on targeting and addressing parents' alcohol misuse, particularly in the antenatal or postnatal period. 相似文献
995.
Pamala A. Pawloski PharmD Ann M. Geiger PhD MPH Reina Haque PhD MPH Aruna Kamineni PhD MPH Hassan Fouayzi MS Jessica Ogarek MS Hans V. Petersen MS Jaclyn L. F. Bosco PhD MPH Soe Soe Thwin PhD MS Rebecca A. Silliman MD PhD Terry S. Field DSc 《Journal of the American Geriatrics Society》2013,61(6):888-895
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Jung Sun Lee PhD RD Edward A. Frongillo PhD Maria A. Keating BA Lauren H. Deutsch Jaclyn Daitchman Dominic E. Frongillo BS 《Journal of nutrition in gerontology and geriatrics》2013,32(3-4):405-415
ABSTRACT The Home-Delivered Meals Program (HDM) is an essential component of home-and community-based services available through the National Aging Service Network in the United States. It has the potential to help delay institutionalization and stem rising health care costs for older Americans; little is known, however, about the targeting practices used for HDM. A nationally representative telephone survey of state and local program providers showed that a variety of outreach measures were being employed, but challenges such as inadequate resources, waiting lists, rural delivery, and misconceptions about the program require resolution to ensure optimal service outcomes. 相似文献