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排序方式: 共有4686条查询结果,搜索用时 15 毫秒
941.
Vanesa Gregorc Rabab M Gaafar Adolfo Favaretto Francesco Grossi Jacek Jassem Andreas Polychronis Paolo Bidoli Marcello Tiseo Riyaz Shah Paul Taylor Silvia Novello Alberto Muzio Alessandra Bearz Laurent Greillier Floriana Fontana Giulia Salini Antonio Lambiase Mary OBrien 《The lancet oncology》2018,19(6):799-811
942.
In this work, Ba2MgWO6: Eu3+ (BMW: Eu3+) ceramic materials with a double perovskite structure were sintered using the High-Pressure Low-Temperature sintering (HPLT) technique. As part of the research, the influence of pressure (CP), sintering temperature (CT), and sintering time (CTS) on the structure and luminescence of the doped BMW were determined. Structural analysis via XRD and SEM + EDS and spectroscopic analysis via emission and excitation spectra, decay time, and absorption spectra of the obtained ceramics were performed. Dense double perovskite ceramics were obtained with a cubic structure with optimal sintering parameters: T = 500 °C, p = 8 GPa, and t = 1 min. The increase in temperature caused an increased extinction of the luminescence due to the diffusion of carbon into the ceramics. The increase in pressure led to the formation of the amorphous phase, which increased the speed of non-radiative transitions and also led to the extinction of the luminescence. The increase in sintering time from 1 to 3 min enhanced the luminescence output, but when the ceramic was sintered for 5 min, the luminescence was quenched, most likely by increasing the rate of the non-radiative process, as evidenced by reduced decay time. 相似文献
943.
A characteristic feature of sintered stainless steel (SSS) is its porosity. Porosity results in a lower density of steel, making attractive components for producing lightweight structures and materials used in industry (e.g., the automotive industry or aerospace). Scientists also observe that porosity adversely affects steel’s properties, especially its strength properties. One of the proposals for improving the discussed properties is the use of surface treatment of sintered stainless steels, e.g., with the use of concentrated energy sources such as plasma beams or laser beams. However, this proposal is an incidental subject of research, which is not justified from the point of view of the obtained research results presented by a few research groups. In this study, the surface modification (surface treatment) of sintered stainless steel was presented. The authors proposed the use of two surface treatments in order to compare them and obtain the best results. The first treatment was the deposit of Cr3C2–NiCr coatings on SSS surfaces using the atmospheric plasma spraying (APS) method. The second treatment was to create surface layers on SSSs by laser alloying the surface with a CO2 laser. Due to high precision and ease of automation, the most common methods in surface alloying treatment are laser technologies. This research’s main aim was to analyze the microstructure and strength properties of the SSS surface layer. The research confirms that applying the Cr3C2–NiCr coating and modifying the surface layer through the laser alloying method improves the mechanical properties of SSSs. 相似文献
944.
This article presents the results of the interlaboratory comparison (ILC) study of the following four characteristics of ceramic tile adhesives (CTAs): initial tensile adhesion strength, tensile adhesion strength after heat ageing, tensile adhesion strength after immersion in water, and tensile adhesion strength after freeze–thaw cycles. The results showed that the objective of the ILC was achieved—the z-score analysis carried out following ISO 13528 allowed for classifying all results obtained by 23 laboratories out of 27 as satisfactory. The results of the remaining four laboratories were rated worse. Despite the achieved goal, the ILC notes high heterogeneity of the results in terms of failure patterns, as well as significant differences between the lowest and the highest values of tensile adhesion strength for various measurement conditions. The results of the ILC were discussed in terms of the possibility of including them in the risk analysis conducted by the manufacturer. The results of the ILC are also valuable information for market surveillance authorities, who, in the authors’ opinion, should be more cautious about results on samples taken from the market. The ILC results for CTAs are also a valuable recommendation for a possible revision of EN 12004. 相似文献
945.
Jacek Pika Micha Kwany Adam Filipkowski Ryszard Buczyski Mirosaw A. Karpierz Urszula A. Laudyn 《Materials》2022,15(21)
We study an optical device designed for converting the polarized Gaussian beam into an optical vortex of tunable polarization. The proposed device comprised a set of three specially prepared nematic liquid crystal cells and a nano-spherical phase plate fabricated from two types of glass nanotubes. This device generates a high-quality optical vortex possessing one of the multiple polarization states from the uniformly polarized input Gaussian beam. Its small size, simplicity of operation, and electrical steering can be easily integrated into the laboratory and industrial systems, making it a promising alternative to passive vortex retarders and spatial light modulators. 相似文献
946.
Epigenetics is a series of alterations regulating gene expression without disrupting the DNA sequence of bases. These regulatory mechanisms can result in embryogenesis, cellular differentiation, X-chromosome inactivation, and DNA-protein interactions. The main epigenetic mechanisms considered to play a major role in both health and disease are DNA methylation, histone modifications, and profiling of non-coding RNA. When the fragile balance between these simultaneously occurring phenomena is disrupted, the risk of pathology increases. Thus, the factors that determine proper epigenetic modeling are defined and those with disruptive influence are sought. Several such factors with proven negative effects have already been described. Diet and nutritional substances have recently been one of the most interesting targets of exploration for epigenetic modeling in disease states, including autoimmunity. The preventive role of proper nutrition and maintaining sufficient vitamin D concentration in maternal blood during pregnancy, as well as in the early years of life, is emphasized. Opportunities are also being investigated for affecting the course of the disease by exploring nutriepigenetics. The authors aim to review the literature presenting vitamin D as one of the important nutrients potentially modeling the course of disease in selected autoimmune disorders. 相似文献
947.
Ahsan Hameed Edyta Adamska-Patruno Joanna Godzien Przemyslaw Czajkowski Urszula Miksza Karolina Pietrowska Joanna Fiedorczuk Monika Moroz Witold Bauer Julia Sieminska Maria Grska Adam Jacek Krtowski Michal Ciborowski 《Nutrients》2022,14(20)
The relationship of high-carbohydrate (HC) meal intake to metabolic syndrome is still not fully explained. Metabolomics has the potential to indicate metabolic pathways altered by HC meals, which may improve our knowledge regarding the mechanisms by which HC meals may contribute to metabolic syndrome development. The fasting and postprandial metabolic response to HC or normo-carbohydrate (NC) meals with/without cinnamon + capsicum intake was evaluated using untargeted metabolomics and compared between normal-weight (NW) and overweight/obese (OW/OB) healthy men. Healthy male participants (age-matched) were divided into two groups (12 subjects per group). One was composed of men with normal weight (NW) and the other of men with overweight/obesity (OW/OB). On separate visits (with 2–3 week intervals), the participants received standardized HC or NC meals (89% or 45% carbohydrates, respectively). Fasting (0 min) and postprandial (30, 60, 120, 180 min) blood were collected for untargeted plasma metabolomics. Based on each metabolic feature’s intensity change in time, the area under the curve (AUC) was calculated. Obtained AUCs were analyzed using multivariate statistics. Several metabolic pathways were found dysregulated after an HC meal in people from the OW/OB group but not the NW group. The consumption of HC meals by people with overweight/obesity led to a substantial increase in AUC, mainly for metabolites belonging to phospholipids and fatty acid amides. The opposite was observed for selected sphingolipids. The intake of cinnamon and capsicum normalized the concentration of selected altered metabolites induced by the intake of HC meals. A HC meal may induce an unfavourable postprandial metabolic response in individuals with overweight/obesity, and such persons should avoid HC meals. 相似文献
948.
949.
Maciej Zacharski Alicja Tomaszek Liliana Kiczak Maciej Ugorski Jacek Bania Urszula Pasławska Ilona Rybinska Ewa Anita Jankowska Adrian Janiszewski Piotr Ponikowski 《Journal of cardiac failure》2021,27(6):682-692
BackgroundSteroid hormones play an important role in heart failure (HF) pathogenesis, and clinical data have revealed disordered steroidogenesis in male patients with HF. However, there is still a lack of studies on steroid hormones and their receptors during HF progression. Therefore, a porcine model of tachycardia-induced cardiomyopathy corresponding to HF was used to assess steroid hormone concentrations in serum and their nuclear receptor levels in heart tissue during the consecutive stages of HF.Methods and ResultsMale pigs underwent right ventricular pacing and developed a clinical picture of mild, moderate, or severe HF. Serum concentrations of dehydroepiandrosterone, testosterone, dihydrotestosterone, estradiol, aldosterone, and cortisol were assessed by enzyme-linked immunosorbent assay. Androgen receptor, estrogen receptor alpha, mineralocorticoid receptor, and glucocorticoid receptor messenger RNA levels in the left ventricle were determined by qPCR.The androgen level decreased in moderate and severe HF animals, while the corticosteroid level increased. The estradiol concentration remained stable. The quantitative real-time polymerase chain reaction revealed the downregulation of androgen receptor in consecutive stages of HF and increased expression of mineralocorticoid receptor messenger RNA under these conditions.ConclusionsIn the HF pig model, deteriorated catabolic/anabolic balance, manifested by upregulation of aldosterone and cortisol and downregulation of androgen signaling on the ligand level, was augmented by changes in steroid hormone receptor expression in the heart tissue. 相似文献
950.
This article proposes an indirect measurement method based on a dimensional and shape analysis of forgings for the evaluation of the manufacture and the proper operation of the key elements of the crank press, in which after modernization, a quick tool assembly based on SMED (Single Minute Exchange of Die) was implemented. As a result of the introduced changes aiming at improving the forging aggregate and increasing the production efficiency, errors were observed on the manufactured products-forgings in the form of twists and joggles. In order to solve the problem, a lot of advanced methods was used, including: dynamic system of deformation analysis, numerical modeling and as well as dimensional and shape analysis by 3d scanning. Despite the above, this approach (classic way) did not solve the problem. A proprietary method with the use of 3D reverse scanning was proposed, which allows to solve the problem of forgings errors. Based on the measurement results and analyses for a few variants of production cycles, the necessary changes were obtained, making it possible to minimize the errors and obtain proper products in respect of geometry and quality. 相似文献