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排序方式: 共有3398条查询结果,搜索用时 15 毫秒
11.
Milica Zekovi Jelena Mileevi Marija Taki Marija Knez Ivana arac Agnes Kadvan Mirjana Gurinovi Marija Glibeti 《Nutrients》2022,14(15)
The Serbian Food Consumption Survey among 1–9-year-old-children was conceptualized and conducted in compliance with the principles, established protocols, and guidelines of the EU Menu project between 2017 and 2021. Valid data were collected for 576 individuals (290 1–3-year-old toddlers and 276 3–9-year-old children). Regardless of age and gender category, the majority (68.80%) of children had normal weights according to the Body Mass Index-for-age classification system. The median daily energy intake was 1406.71 kcal with no differences between the settlement types. The overall median contributions of carbohydrates, protein, and fat to the total energy intake were 47.54%, 14.06%, and 37.88%, respectively. The proportions of the macronutrient intake deviated from the dietary reference values with compliance to the recommendations being particularly poor for fat and fiber. The consumption of energy-dense food groups such as meat and meat products, fat and oil, sugar, and confections was more pronounced among older children. The survey results provide a valuable insight into the nutritional status and dietary habits of toddlers and children 1–9 years old living in Serbia. They may serve as an evidence platform for public health programs, a valuable asset for decision-makers, and a reliable reference to guide nutritional policies, diet monitoring, and interventions targeting this population group in the future. 相似文献
12.
James Larkin Michele Del Vecchio Paolo A Ascierto Ivana Krajsova Jacob Schachter Bart Neyns Enrique Espinosa Claus Garbe Vanna Chiarion Sileni Helen Gogas Wilson H Miller Mario Mandalà Geke A P Hospers Ana Arance Paola Queirolo Axel Hauschild Michael P Brown Lada Mitchell Christian U Blank 《The lancet oncology》2014,15(4):436-444
13.
Nataša Mitrović Marina Zarić Dunja Drakulić Jelena Martinović Jean Sévigny Miloš Stanojlović Nadežda Nedeljković Ivana Grković 《Journal of molecular neuroscience : MN》2017,61(3):412-422
17β-Estradiol (E2) rapidly, by binding to membrane estrogen receptors, activates cell signaling cascades which induce formation of new dendritic spines in the hippocampus of males as in females, but the interaction with other metabolic processes, such as extracellular adenine nucleotides metabolism, are currently unknown. Extracellular adenine nucleotides play significant roles, controlling excitatory glutamatergic synapses and development of neural circuits and synaptic plasticity. Their precise regulation in the synaptic cleft is tightly controlled by ecto-nucleoside triphosphate diphosphohydrolase (NTPDase)/ecto-5′-nucleotidase (eN) enzyme chain. Therefore, we sought to clarify whether a single systemic injection of E2 in male rats is accompanied by changes in the expression of the pre- and postsynaptic proteins and downstream kinases linked to E2-induced synaptic rearrangement as well as alterations in NTPDase/eN pathway in the hippocampal synaptosomes. Obtained data showed activation of mammalian target of rapamycin and upregulation of key synaptic proteins necessary for spine formation, 24 h after systemic E2 administration. In E2-mediated conditions, we found downregulation of NTPDase1 and NTPDase2 and attenuation of adenine nucleotide hydrolysis by NTPDase/eN enzyme chain, without changes in NTPDase3 properties and augmentation of synaptic tissue-nonspecific alkaline phosphatase (TNAP) activity. Despite reduced NTPDase activities, increased TNAP activity probably prevents toxic accumulation of ATP in the extracellular milieu and also hydrolyzes accumulated ADP due to unchanged NTPDase3 activity. Thus, our initial evaluation supports idea of specific roles of different ectonucleotidases and their coordinated actions in E2-mediated spine remodeling and maintenance. 相似文献
14.
Illitic clays are the commonly used material in building ceramics. Zeolites are microporous, hydrated crystalline aluminosilicates, they are widely used due to their structure and absorption properties. In this study, illitic clay (Füzérradvány, Hungary) was mixed with natural zeolite (Nižný Hrabovec, Slovakia) with up to 50 wt.% of zeolite content. The samples were submitted to thermal analyses, such as differential thermal analysis, differential scanning calorimetry, thermogravimetry, and dilatometry. In addition, the evolution of thermal diffusivity, thermal conductivity, and specific heat capacity in the heating stage of firing were measured and discussed. The amount of the physically bound water in the samples increased along with the amount of zeolite. The temperature of the illite dehydroxylation (peak temperature) was slightly shifted to lower temperatures, from 609 °C to 575 °C (for sample IZ50). On the other hand, the mass loss and the shrinkage of the samples significantly increased with the zeolite content in the samples. Sample IZ50 reached 10.8% shrinkage, while the sample prepared only from the illitic clay contracted by 5.8%. Nevertheless, the temperature of the beginning of the sintering (taken from the dilatometric curves) decreased from 1021 °C (for illitic clay) to 1005 °C (for IZ50). The thermal diffusivity and thermal conductivity values decreased as the amount of zeolite increased in the samples, thus showing promising thermal insulating properties. 相似文献
15.
16.
Silvana Jukić Krmek Ivana Bogdan Paris Simeon Goranka Prpić Mehičić Davor Katanec Ivica Anić 《Lasers in medical science》2010,25(6):823-828
The aim of this study was to evaluate microleakage along resin restoration in cavities prepared with an erbium:yttrium–aluminium–garnet
(Er:YAG) laser, with and without acid etching, and to compare it with that in diamond-drilled cavities. Thirty intact molars
were divided into three equal groups. In the teeth in group I, class V cavities were prepared with a diamond drill. Cavities
in groups II and III were prepared with an Er:YAG laser (400 mJ/15 Hz for enamel and 250 mJ/10 Hz for dentine). The cavities
in groups I and II were acid-etched and adhesive and flowable composite were applied to all cavities. The specimens were first
immersed in dye for 24 h and then in 5% nitric acid for 72 h for softening. The fillings were extracted and photographed through
a dissecting microscope. The leakage area was measured with specially designed software. The Kruskal–Wallis test showed that
the best ranking was group II [mean range (m.r.) = 27.46], followed by group I (m.r. = 33.48) and, lastly, group III (m.r. = 45.15).
The differences between groups I and III (P = 0.023) and between groups II and III were statistically significant (P = 0.080). The least microleakage was found in those cavities prepared by Er:YAG laser and subsequently acid-etched, whereas
the most leakage was in the lased cavities that had not been etched; the traditional diamond-drilled acid-etched cavities
produced medium leakage. 相似文献
17.
Likić-Ladjević I Argirović R Kadija S Maksimović M Zivaljević B Terzić M 《Acta chirurgica Iugoslavica》2011,58(2):193-199
All the elective surgeries are to be avoided during pregnancy and pregnant women should undergo only emergency surgical interventions. Pregnancy is associated with different physiological changes in the organism, which should be taken into account in preparative preparation of the pregnant women. Expanded body fluid volume leads to dilutional anemia, however other hematological disorders may be present as well. Extreme obesity is a frequent comorbidity, while hypertension is associated with the highest risks since it may lead to a life-threatening complication--eclampsia. As for other coexisting diseases, urinary tract infections and gestational diabetes are the most common as well as hyperthyroidism and other diseases that may also develop. The type and severity of the acute surgical disease, extensiveness of the planned surgery as well as the type of planned anesthesia to be applied, occasionally necessitate, depending on the gestational age, termination of pregnancy to be considered. Gynecological-obstetric consultations are mandatory in all surgical interventions planned in pregnant women. 相似文献
18.
Pavik I Jaeger P Kistler AD Poster D Krauer F Cavelti-Weder C Rentsch KM Wüthrich RP Serra AL 《Kidney international》2011,79(2):234-240
Fibroblast growth factor 23 (FGF23) and parathyroid hormone blood levels rise following progressive loss of renal function. Here we measured parameters of phosphate metabolism in 100 patients with autosomal dominant polycystic kidney disease (ADPKD) in stage 1 or 2 of chronic kidney disease, 20 patients with non-diabetic chronic kidney disease, and 26 with type 2 diabetes. Twenty healthy volunteers served as controls. The mean levels of FGF23 were significantly (4-fold) higher in ADPKD compared to non-diabetic and diabetic patients, and healthy volunteers. Mean serum phosphate levels were significantly lower in ADPKD patients compared to non-diabetic and diabetic patients, and the healthy volunteers. The prevalence of hypophosphatemia was 38, 25, 27, and 5% in ADPKD, non-diabetic and diabetic patients, and healthy volunteers, respectively. The tubular maximum of phosphate reabsorption per glomerular filtration rate was lowest in ADPKD patients with a significantly high positive correlation with serum phosphate levels. Estimated glomerular filtration rates were approximately 100 ml/min per 1.73 m2 in all groups and parathyroid hormone and vitamin D metabolite levels were in the normal range. Thus, FGF23 was substantially elevated in ADPKD patients compared to other CKD patients matched for glomerular filtration rate, and was associated with increased renal phosphate excretion. The mechanism for this anomaly will require further study. 相似文献
19.
20.
Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans 总被引:5,自引:0,他引:5
In this study, we have examined the correlation between the histological and histochemical changes of articular cartilage and bone parameters of the underlying subchondral bone. The aim was to elucidate patterns of bone parameter changes within different depths of subchondral bone in the joints with macroscopically normal cartilage and in joints with osteoarthritis (OA). Ten tibial plateaus were taken from patients during total knee replacement surgery due to severe OA. They were compared with 10 sets of tibial condyles obtained from autopsy subjects with no history of bone or joint disease. The cylindrical cartilage-bone samples were taken out from the anterior, posterior, external, and internal areas of the condyles for cartilage assessment (Mankin score) and subchondral bone histomorphometry. Four histomorphometric parameters were measured: bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.S). Our study showed that subchondral bone from the OA group had significantly higher bone volume (54.1 +/- 10.6%) than control group (37.8 +/- 8.1%) (P < 0.01). In addition, trabecular parameters from the OA subchondral bone showed a smaller number of sparsely distributed and thicker trabecules than in control group (P < 0.05). Medial and lateral condyle from the control group did not differ significantly, while medial condyle from OA group showed a high increase of bone volume (62.8 +/- 13.3) and consecutively different trabecular parameters when compared with the lateral condyle from the same group. Also, it was shown that there are regional differences (anterior, posterior, internal, and external) in bone parameters between both condyles within both, control and OA groups. Comparison of bone parameters from three different stage of articular cartilage degeneration (Mankin score) showed that higher degree of cartilage degeneration is followed by significant changes in subchondral bone architecture. Furthermore, we have found that progression of cartilage degeneration leads to changes in bone parameters which affected deeper levels of subchondral bone. According to these results, it can be suggested that changes in histomorphometric parameters of subchondral bone are secondary to cartilage damage and proceed deeper into subchondral bone with increasing cartilage degeneration. 相似文献