全文获取类型
收费全文 | 5170篇 |
免费 | 194篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 90篇 |
妇产科学 | 80篇 |
基础医学 | 725篇 |
口腔科学 | 144篇 |
临床医学 | 290篇 |
内科学 | 1420篇 |
皮肤病学 | 52篇 |
神经病学 | 329篇 |
特种医学 | 173篇 |
外科学 | 946篇 |
综合类 | 41篇 |
预防医学 | 162篇 |
眼科学 | 51篇 |
药学 | 268篇 |
中国医学 | 38篇 |
肿瘤学 | 561篇 |
出版年
2024年 | 7篇 |
2023年 | 24篇 |
2022年 | 52篇 |
2021年 | 95篇 |
2020年 | 54篇 |
2019年 | 62篇 |
2018年 | 83篇 |
2017年 | 68篇 |
2016年 | 63篇 |
2015年 | 85篇 |
2014年 | 120篇 |
2013年 | 139篇 |
2012年 | 290篇 |
2011年 | 327篇 |
2010年 | 165篇 |
2009年 | 177篇 |
2008年 | 280篇 |
2007年 | 335篇 |
2006年 | 339篇 |
2005年 | 395篇 |
2004年 | 375篇 |
2003年 | 386篇 |
2002年 | 397篇 |
2001年 | 39篇 |
2000年 | 51篇 |
1999年 | 85篇 |
1998年 | 103篇 |
1997年 | 102篇 |
1996年 | 94篇 |
1995年 | 75篇 |
1994年 | 49篇 |
1993年 | 52篇 |
1992年 | 34篇 |
1991年 | 27篇 |
1990年 | 33篇 |
1989年 | 31篇 |
1988年 | 32篇 |
1987年 | 21篇 |
1986年 | 32篇 |
1985年 | 24篇 |
1984年 | 24篇 |
1983年 | 22篇 |
1982年 | 15篇 |
1981年 | 23篇 |
1980年 | 18篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1977年 | 12篇 |
1976年 | 11篇 |
1975年 | 10篇 |
排序方式: 共有5389条查询结果,搜索用时 15 毫秒
91.
92.
Different outcomes of vertical transmission of hepatitis C virus in a twin pregnancy 总被引:4,自引:0,他引:4
Inui A Fujisawa T Sogo T Komatsu H Isozaki A Sekine I 《Journal of gastroenterology and hepatology》2002,17(5):617-619
The risk of vertical transmission of hepatitis C virus (HCV) from mother to infant has been well documented, but the exact mode of transmission is still unclear. In a set of monochorionic diamniotic monozygous twins, only the second baby was infected with HCV from the mother who was positive for serum HCV-RNA. The babies had an uncomplicated vaginal delivery 3 min apart and they were both bottle fed from the outset. The second baby developed clinical hepatitis that persisted to 30 months follow up. The intrauterine environment should have been identical for these twins, and therefore, the maternal HCV factors, including viral load are not the sole determining factors for mother-to-infant transmission of HCV. 相似文献
93.
Although there are various treatments for postherpetic neuralgia (PHN), none produces definitive effects. We report a case of 72-year-old woman who developed intractable PHN of the chest in which treatment with endoscopic transthoracic sympathicotomy (ETS) produced long-term effective results. When hyperesthesia of the sympathetic nerve participates in PHN, the blocking of sympathetic excitation seems to be effective for PHN suppression. The method using a single resectoscope is safe, accurate, yields excellent results cosmetically, and generates minimal invasion and very little postoperative pain. Although ETS is not always effective for all cases of PHN, it could be a useful method of treating patients with PHN that is resistant to conventional therapies. 相似文献
94.
Takahashi H Takeishi Y Seidler T Arimoto T Akiyama H Hozumi Y Koyama Y Shishido T Tsunoda Y Niizeki T Nozaki N Abe J Hasenfuss G Goto K Kubota I 《Circulation》2005,111(12):1510-1516
95.
Yamanouchi H Izumikawa K Hisamatsu T Yoshinaga M Sasaki E Izumikawa K Hayakawa T Hara K Maruyama S Ohtani H Shimokawa I 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2004,78(3):270-273
A 50-year-old male with left cervical lymphadenopathy visited our hospital. Infectious and lymphomatous diseases were suspected in the patient. Since the patient owned a dog, which often licked the patient's face, Bartonella infection was also suspected. Histopathological examination in the lymph node biopsy revealed the epithelioid granuloma, but B. henselae was not detected from the culture of the lymphnode. B. henselae DNA also was not detected from the lymph node. Since the antibody titer (lgG) to B. henselae showed 1:128 by immunofluorescent antibody technique (IFA), he was serdogicalg diagnosed as cat-scratch disease. 'Cat-scratch disease' is named after cat scratch, however we propose 'B. henselae infection' which is more appropriate since other animals could serve as a cause of infection. 相似文献
96.
Nobuyuki Kamio Isao Kobayashi Masatomo Mori Teruo Uehara Hitoshi Fukuda Kazutoshi Tsuyusaki Yasuko Nakamua Setsuo Kobayashi 《Metabolism: clinical and experimental》1977,26(3):295-299
Serial measurements of serum triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), and 4-hr thyroidal 131I uptake were carried out in nine patients with subacute thyroiditis. In the acute phase, suppressed TSH and 131I uptake were observed simultaneously with the elevations of T3 and T4. Thyrotropin-releasing hormone (TRH) failed to increase TSH in all patients studied. The mean value of an increment in serum TSH was only 1.8 μU/ml during the recovery phase when 131I uptake was normal or hyper-normal. In addition, and elevated 131I uptake was not necessarily associated with an immediate increase in the serum T3 and T4. These observations suggest that the resumption of the iodide pump may be more important than an increment in TSH in producing normal or hypernormal 131I uptake during the recovery phase. There appears to be a dissociation between the reestablishment of 131I uptake and the resumption of the mechanism of hormonal synthesis and secretion in the thyroid. 相似文献
97.
Hiroyuki Furuya Hiroyuki Aikawa Takahiko Yoshida Isao Okazaki 《Alcoholism, clinical and experimental research》1996,20(S9):305A-310A
Children born from chronic alcoholic mothers have shown behavioral teratogenic effects more frequently than morphological malformations. To investigate the possible mechanisms and evaluate maternal alcohol dosage levels to induce behavioral dysfunctions, we gave pregnant Tokai High Avoider (THA) rats 0, 5,10, and 20% ethanol (EtOH) as drinking water during the gestation period. We evaluated the brain function of pups born of alcohol-administered dams. Sidman avoidance behavior test and the levels of monoamines (nor-adrenalin, dopamine, and serotonin) and metabolites (3,4-dihydroxy-phenyl acetic acid, homovanillic acid, and 5-hydroxyindole acetic acid) in whole brain were examined for neurobehavioral and neurochemical effects. EtOH-exposed THA offsprings showed high pre-and postnatal mortality, growth deficits, and brain weight reductions. Compared with the results of the same conditioning experiment using Wistar rats, the THA rat may have higher susceptibility to the effects of in utero EtOH exposure than Wistar rats. EtOH-exposed THA pups exhibited deficits in avoidance operant learning that were not shown in Wistar rats. We also observed the increased levels of all monoamines that were assumed to be related with the deficit of learning, the decreased levels of 3,4-dihydroxyphenyl acetic acid and homovanillic acid, and the unchanged levels of 5-hydroxyindole acetic acid in pups from dams administered 10 and 20% EtOH. However, contrary alteration of monoamines and their metabolites were shown in pups from 5% EtOH-administered dams. 相似文献
98.
Takeuchi M Yoshida I Takahashi K 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2003,44(11):1069-1073
Seven patients experiencing first (n = 5) or second (n = 2) relapse of acute promyelocytic leukemia (APL) were treated with a new synthetic retinoid, Am-80. All 7 patients were previously treated with all-trans retinoic acid (ATRA). Am-80 was orally administered at a dose of 6 mg/m2 daily. Chemotherapy was combined in 3 patients because of leukocytosis. All 7 patients achieved a complete remission (CR) during periods ranging from 36-56 days (median 52 days). Adverse effects such as hyperlipidemia and skin lesions, were tolerable. After achieving CR, 3 patients underwent allogeneic bone marrow transplantation and 4 patients received only consolidation chemotherapy. In 2 of 3 patients who received allogeneic transplantation, relapse free survival has lasted for 9.7 and 28.3 months. Furthermore, in 2 of 4 patients who received only chemotherapy, relapse free survival has lasted for 84.7 and 90.1 months. Am-80 is an active agent for APL patients who have relapsed from ATRA-induced remission. 相似文献
99.
Misaki Kageyama Hideharu Hagiya Yasutaka Ueda Katsuki Ohtani Yasuo Fukumori Norimitsu Inoue Nobutaka Wakamiya Nanoka Yoneda Keigo Kimura Motonori Nagasawa Futoshi Nakagami Isao Nishi Ken Sugimoto Hiromi Rakugi 《Medicine》2021,100(13)
Rationale:Complement deficiency are known to be predisposed to disseminated gonococcal infection (DGI). We herein present a case of DGI involving a Japanese man who latently had a complement 7 deficiency with compound heterozygous variants.Patient concerns:A previously healthy 51-year-old Japanese man complained of sudden-onset high fever. Physical examination revealed various skin lesions including red papules on his trunk and extremities, an impetigo-like pustule on left forearm, and tendinitis of his right forefinger.Diagnosis:Blood culture testing detected gram-negative cocci, which was confirmed to be Neisseria gonorrhoeae based on mass spectrometry and a pathogen-specific PCR test.Interventions:Screening tests for underlying immunocompromised factors uncovered that complement activities (CH50) was undetectable. With a suspicion of a congenital complement deficiency, genetic analysis revealed rare single nucleotide variants in complement 7 (C7), including c.281-1G>T and a novel variant c.1454C>T (p.A485V). CH50 was normally recovered by adding purified human C7 to the patient''s serum, supporting that the patient has C7 deficiency with compound heterozygous variants.Outcomes:Under a diagnosis of DGI, the patient underwent an antibiotic treatment with cefotaxime for a week and was discharged without any sequela.Lessons:DGI is a rare sexually-transmitted infection that potentially induces systemic complications. Complement immunity usually defeats N. gonorrhoeae and prevents the organism from causing DGI. This case highlighted the importance of suspecting a complement deficiency when a person develops DGI. 相似文献
100.
Effects of cyclosporin A on water-immersion stress-induced gastric lesion and gastric secretion in rats 总被引:1,自引:0,他引:1
Odashima M Otaka M Ito S Iwabuchi A Wada I Konishi N Pacheco I Sato T Kato S Watanabe S 《Journal of gastroenterology》2000,35(5):369-371
Cyclosporin A is an immunosuppressive agent which is well known as a specific inhibitor of calcineurin (protein phosphatase
2B). In this study, we investigated the effects of cyclosporin A on water-immersion stress-induced gastric ulcer formation
and gastric acid secretion in rats. We also examined the localization of calcineurin immunohistochemically. Calcineurin was
specifically expressed in gastric parietal cells and chief cells of the gastric mucosa. The intraperitoneal administration
of cyclosporin A dose-dependently suppressed the development of gastric mucosal lesions induced by water-immersion stress
and inhibited gastric acid secretion, as assessed by pylorus ligation. These results indicated that calcineurin may play an
important role in gastric acid secretion.
Received: October 14, 1999 / Accepted: January 28, 2000 相似文献