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31.
Summary Results of re-operations of 99 adult patients with recurrent supratentorial lobar glioblastomas (60 patients) and anaplastic
astrocytomas (39 patients) have been reviewed. In all cases both surgical interventions were performed at the same institute.
Age of patients with glioblastoma varied between 19 and 64 and with anaplastic astrocytoma between 21 and 68 years, with a
mean value of 48 and 36 years, respectively. The median interval between the first and second operations was 47 weeks for
patients with glioblastoma and 83 weeks with anaplastic astrocytoma. The mortality rate of the re-operations was 3%. Following
re-operation radio-and/or chemotherapy was applied in most of the cases. Median survival time after re-operation was 18.5
weeks in patients with glioblastoma and 55 weeks with anaplastic astrocytoma. Survival curves were calculated according to
Kaplan-Meier method and for statistical evaluation the generalized Wilcoxon test and multiple linear regression method were
used.
Histologically lower grade tumour at the first operation and longer interval between the two operations proved to influence
positively and differentiation of the primary tumour negatively the survival time. 相似文献
32.
Alex Iranzo Esteban Mu?oz Joan Santamaria Isabel Vilaseca Montserrat Milà Eduardo Tolosa 《Movement disorders》2003,18(10):1179-1183
We evaluated the occurrence of REM sleep behaviour disorder (RBD) and vocal cord abductor paralysis (VCAP) in a group of 9 Machado-Joseph disease (MJD) patients. RBD was diagnosed by clinical history plus audiovisual polysomnography in 4 men and 1 woman (55%). While dreaming, 4 fell out of the bed and the other injured his arms. Laryngoscopy detected bilateral VCAP in 1 patient with stridor who required emergency tracheotomy, and partial vocal cord abductor restriction in 2. RBD and VCAP are two potentially injurious conditions that should be considered part of the clinical spectrum of MJD. 相似文献
33.
Nuno Fonseca Filomena Caetano José Santos Filipe Seixo Leonel Bernardino Isabel Silvestre Paula Cardoso Filomena Segurado Lopes Inês 《Revista portuguesa de cardiologia》2004,23(3):365-375
INTRODUCTION: In patients (pts) with atrial fibrillation (AF) of more than 48 hours' duration, electrical cardioversion (ECV) should only be performed after 3 weeks of effective anticoagulation. Transesophageal echocardiography (TEE) allows earlier ECV; however, despite exclusion of thrombi in the atrium and left atrial appendage (LAA), cases of thromboembolism related to ECV have been documented in AF. To define a low-risk group for cardioversion without previous anticoagulation, pts were selected for immediate ECV if no thrombi or dynamic spontaneous echo contrast (auto-contrast) were found after TEE and if LAA velocity was more than 0.25 m/sec. METHODS AND RESULTS: We performed TEE in 31 consecutive pts referred for ECV for AF of more than 48 hours' duration and without previous anticoagulation. After TEE the pts eligible for immediate ECV began anticoagulation with low molecular weight heparin (enoxaparin), subcutaneously in therapeutic doses, together with warfarin immediately before cardioversion. Enoxaparin was continued until an INR of over 2 was reached. Based on the TEE findings, the pts were divided in 2 groups: immediate ECV, group A, 20 pts with a mean age of 62 +/- 13 years, 6 female; and conventional therapy with warfarin before ECV, group B, 11 pts, mean age of 67 +/- 10 years (p < 0.05), 2 female. None of the pts in either group had mitral stenosis or previous episodes of thromboembolism. The mean transverse diameter of the left atrium in the 31 pts was 47 +/- 4.5 mm, without statistically significant differences between the 2 groups. Of the 11 pts in group B, 3 had a thrombus in the LAA, 6 dynamic spontaneous echo contrast and the remainder LAA velocities of less than 0.25 m/sec. ECV was achieved in all the pts, with no complications. Oral anticoagulation was maintained for at least a month. At one month, sinus rhythm was maintained in 75% of group A and 45% of group B (p < 0.01). CONCLUSION: In pts with AF of more than 48 hours' duration and no previous history of thromboembolism, the use of our exclusion criteria during TEE enabled stratification of a low-risk population for immediate ECV, which was accomplished effectively and safely in 2/3 of the pts. This strategy is associated with early symptomatic improvement, and may contribute to maintenance of sinus rhythm after one month, which was significantly better than in the pts who had prolonged therapy with warfarin before ECV, despite the differences found in age and left ventricular function. 相似文献
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36.
Juan M. Verdeguer M.D. Dolores Ramon M.D. Manuel Moragon M.D. Isabel Betlloch M.D. Esperanza Jorda M.D. M.D Victoria Planelles M.D. † 《Pediatric dermatology》1988,5(1):56-57
Abstract: Hydantoin is an anticonvulsant drug with several side effects. A teralogenic potential has been suggested. The fetal hydantoin syndrome is an entity that consists of a broad range of morphologic and developmental disorders in children born of epileptic mothers exposed to hydantoin during pregnancy. We treated a girl in whom onychopathy was a monosymptomatic or mild form of this syndrome. 相似文献
37.
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39.
Pedro Antonio Martínez-Carpio Miguel Ángel Navarro Moreno 《Clinical & translational oncology》2003,5(4):184-191
Resumen La técnica del cultivo celular es la que ha permitido conocer el comportamientoin vitro de las células cancerosas. En esta revisión pretendemos introducir las peculiaridades básicas del cultivo celular, referido
especialmente a líneas cancerosas mamarias, relacionar el origen de las líneas celulares más utilizadas en la investigación
de este cáncer, mencionar las técnicas de laboratorio que pueden aplicarse sobre estos cultivos y ejemplificar la utilidad
de las mismas, tomando como modelo diversos trabajos que estudian los efectos del factor de crecimiento epidérmico sobre líneas
celulares hormonoindependientes de cáncer de mama.
相似文献
40.
Debbie Ehrmann Feldman Mirella de Civita Patricia L. Dobkin Pete Malleson Garbis Meshefedjian CiarÁn M. Duffy 《Arthritis care & research》2007,57(2):226-233