全文获取类型
收费全文 | 2389篇 |
免费 | 312篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 89篇 |
妇产科学 | 46篇 |
基础医学 | 417篇 |
口腔科学 | 75篇 |
临床医学 | 298篇 |
内科学 | 458篇 |
皮肤病学 | 105篇 |
神经病学 | 137篇 |
特种医学 | 272篇 |
外科学 | 186篇 |
综合类 | 74篇 |
一般理论 | 3篇 |
预防医学 | 187篇 |
眼科学 | 106篇 |
药学 | 166篇 |
肿瘤学 | 85篇 |
出版年
2021年 | 23篇 |
2019年 | 34篇 |
2018年 | 38篇 |
2017年 | 28篇 |
2016年 | 22篇 |
2015年 | 35篇 |
2014年 | 48篇 |
2013年 | 56篇 |
2012年 | 52篇 |
2011年 | 84篇 |
2010年 | 65篇 |
2009年 | 59篇 |
2008年 | 66篇 |
2007年 | 104篇 |
2006年 | 72篇 |
2005年 | 60篇 |
2004年 | 70篇 |
2003年 | 67篇 |
2002年 | 84篇 |
2001年 | 78篇 |
2000年 | 77篇 |
1999年 | 68篇 |
1998年 | 85篇 |
1997年 | 90篇 |
1996年 | 88篇 |
1995年 | 60篇 |
1994年 | 47篇 |
1993年 | 50篇 |
1992年 | 49篇 |
1991年 | 49篇 |
1990年 | 52篇 |
1989年 | 77篇 |
1988年 | 67篇 |
1987年 | 56篇 |
1986年 | 62篇 |
1985年 | 51篇 |
1984年 | 25篇 |
1983年 | 33篇 |
1982年 | 20篇 |
1981年 | 23篇 |
1980年 | 25篇 |
1979年 | 20篇 |
1977年 | 26篇 |
1976年 | 24篇 |
1975年 | 18篇 |
1974年 | 37篇 |
1973年 | 26篇 |
1972年 | 21篇 |
1969年 | 31篇 |
1968年 | 23篇 |
排序方式: 共有2733条查询结果,搜索用时 15 毫秒
21.
The development of both adenocarcinoma of the jejunum and in situ squamous carcinoma of the oesophagus in an adult coeliac patient is described. Good evidence that adenocarcinoma of jejunum occurs more frequently in patients with coeliac disease has recently become available though this association has been suggested for some time. While oesophageal carcinoma has long been associated with coeliac disease, in situ carcinoma of oesophagus has not been previously described in these circumstances. We feel that the risk of this complication, as calculated from published series, warrants a screening programme for oesophageal malignancy in adult coeliacs. 相似文献
22.
23.
An autosomal dominant syndrome of acromegaloid facial appearance and generalised hypertrichosis terminalis. 下载免费PDF全文
A D Irvine O M Dolan D R Hadden F J Stewart E A Bingham N C Nevin 《Journal of medical genetics》1996,33(11):972-974
We report a family in which a phenotype of acromegaloid facial appearance (AFA) and generalised hypertrichosis terminalis segregates through three generations. Congenital hypertrichosis terminalis and AFA have been previously reported as independent autosomal dominant traits. This is the first report to delineate an autosomal dominant transmission of the combined phenotype. 相似文献
24.
J. Kalden K. James W. G. Williamson W. J. Irvine 《Clinical and experimental immunology》1969,5(6):597-606
The autoallergic thyroiditis produced in rats by the injection of rat thyroglobulin in Freund's complete adjuvant can be suppressed by the administration of the IgG immunoglobulin fraction of heterologous (horse) anti-lymphocytic serum when treatment is started immediately after the antigen injection. In contrast anti-lymphocytic IgG failed to prevent the development of thyroiditis when given only 4 hr after the antigen nor did it show any suppressive effect on previously induced thyroiditis. Similar results were obtained when anti-lymphocytic IgG treatment was tested for its effect on the primary immune response to rat thyroglobulin. 相似文献
25.
Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn's disease 总被引:2,自引:0,他引:2 下载免费PDF全文
Zareie M Singh PK Irvine EJ Sherman PM McKay DM Perdue MH 《The American journal of pathology》2001,158(3):1101-1109
Intestinal immune cells are less reactive than those in the peripheral blood; however, such cells from patients with Crohn's disease may be more responsive to bacterial products. Our study examined if nonpathogenic bacteria or lipopolysaccharide (LPS), can affect epithelial function in the presence of monocytes/macrophages. Lamina propria mononuclear cells (LPMCs) and peripheral blood monocytes (PBMs) were obtained from patients with Crohn's disease and control patients. Filter-grown T84 epithelial monolayers were co-cultured with nonactivated or LPS-activated LPMCs or PBMs for 48 hours. Epithelial secretory [baseline short-circuit current (Isc) and DeltaIsc to forskolin] and barrier (transepithelial electrical resistance) parameters were measured in Ussing chambers. LPS-activated PBMs from both controls and patients with Crohn's disease significantly increased Isc ( approximately 300%) and reduced transepithelial electrical resistance ( approximately 40%). Epithelial function was not altered after co-culture with control LPMCs +/- LPS. However, LPMCs from patients with Crohn's disease spontaneously secreted tumor necrosis factor-alpha, and induced epithelial changes similar to those produced by LPS-activated PBMs. Co-culture with control Escherichia coli and PBMs induced comparable changes in epithelial physiology, which were abrogated by anti-tumor necrosis factor-alpha antibody. We conclude that LPMCs of patients with Crohn's disease are spontaneously activated, possibly by gram-negative luminal bacteria, and can directly cause significant alterations in epithelial ion transport and barrier functions. 相似文献
26.
27.
Robin F. Irvine 《The Journal of physiology》2005,566(2):295-300
When viewing the changes in our understanding of inositides over the last 20 years, it is difficult to know whether to be more impressed by the proliferation in the number of inositides themselves (e.g. seven polyphosphoinositol lipids, more than 30 inositol phosphates), or by the number of functions for each. This review will focus on two specific aspects of this diversity: the evolution of the polyphosphoinositides, and the synthesis and functions of the higher inositol phosphates. 相似文献
28.
A 50-kDa membrane protein mediates sialic acid-independent binding and infection of conjunctival cells by adenovirus type 37 总被引:6,自引:0,他引:6
The ocular tropism of adenovirus type 37 (Ad37) does not correlate with the wide distribution of the 46-kDa coxsackievirus and adenovirus receptor (CAR), the major receptor for most adenovirus serotypes. We previously found that Ad37 infects and binds well to conjunctival cells (Chang C), but poorly to lung epithelial (A549) cells that express CAR and hypothesized that this serotype uses a distinct receptor that is selectively expressed on conjunctival cells. To test this, we produced particles of a fiber-deleted Ad5 vector containing the Ad37 fiber protein. The "pseudotyped" vector infected Chang C cells better than A549 cells using a CAR-independent pathway. Ad37 binding was calcium-dependent and was abolished by protease digestion of cell surface proteins. Using a virus overlay protein blot assay (VOPBA), we detected calcium-dependent Ad37 binding to 50- and 60-kDa membrane proteins on permissive Chang C cells. In contrast, calcium-dependent binding was detected with only the 60-kDa protein on nonpermissive A549 cells. Ad19p, a closely related serotype that failed to bind to conjunctival cells, recognized the 60-kDa, but not the 50-kDa, protein. Ad37 has been reported to use sialic acid instead of CAR as a cell receptor on A549 cells. Pretreatment of Chang C cells with neuraminidase abolished Ad37 binding to only the 60-kDa protein, suggesting that sialic acid mediates Ad37 binding to the 60-kDa protein. The pseudotyped Ad37 vector was also able to infect neuraminidase-treated Chang C cells. Thus, subgroup D adenoviral binding to the 50-kDa protein is calcium-dependent and cell type- and serotype-specific, whereas binding to the 60-kDa protein is not necessary for infection of conjunctival cells. Together, these data suggest that the 50-kDa protein is the major receptor for Ad37 on conjunctival cells. 相似文献
29.
30.
Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH; Washburn LL; McCarrey JR; Cattanach BM; Lovell-Badge R; Burgoyne PS 《Human molecular genetics》1998,7(4):715-727
An RNA-binding motif (RBM) gene family has been identified on the human Y
chromosome that maps to the same deletion interval as the 'azoospermia
factor' (AZF). We have identified the homologous gene family (Rbm) on the
mouse Y with a view to investigating the proposal that this gene family
plays a role in spermatogenesis. At least 25 and probably >50 copies of
Rbm are present on the mouse Y chromosome short arm located between Sry and
the centromere. As in the human, a role in spermatogenesis is indicated by
a germ cell-specific pattern of expression in the testis, but there are
distinct differences in the pattern of expression between the two species.
Mice carrying the deletion Yd1, that maps to the proximal Y short arm, are
female due to a position effect resulting in non-expression of Sry ;
sex-reversing such mice with an Sry transgene produces males with a high
incidence of abnormal sperm, making this the third deletion interval on the
mouse Y that affects some aspect of spermatogenesis. Most of the copies of
Rbm map to this deletion interval, and the Yd1males have markedly reduced
Rbm expression, suggesting that RBM deficiency may be responsible for, or
contribute to, the abnormal sperm development. In man, deletion of the
functional copies of RBM is associated with meiotic arrest rather than
sperm anomalies; however, the different effects of deletion are consistent
with the differences in expression between the two species.
相似文献