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81.
Acupuncture in patients with acute low back pain: A multicentre randomised controlled clinical trial
J Vas JM Aranda M Modesto N Benítez-Parejo A Herrera DM Martínez-Barquín I Aguilar M Sánchez-Araujo F Rivas-Ruiz 《Pain》2012,153(9):1883-1889
Reviews of the efficacy of acupuncture as a treatment for acute low back pain have concluded that there is insufficient evidence for its efficacy and that more research is needed to evaluate it. A multicentre randomized controlled trial was conducted at 4 primary-care centres in Spain to evaluate the effects of acupuncture in patients with acute nonspecific low back pain in the context of primary care. A total of 275 patients with nonspecific acute low back pain (diagnosed by their general practitioner) were recruited and assigned randomly to 4 different groups: conventional treatment either alone or complemented by 5 sessions over a 2-week period of true acupuncture, sham acupuncture, or placebo acupuncture per patient. Patients were treated from February 2006 to January 2008. The primary outcome was the reduction in Roland Morris Disability Questionnaire scores of 35% or more after 2weeks' treatment. The patients in the 3 types of acupuncture groups were blinded to the treatments, but those who received conventional treatment alone were not. In the analysis adjusted for the total sample (true acupuncture relative risk 5.04, 95% confidence interval 2.24-11.32; sham acupuncture relative risk 5.02, 95% confidence interval 2.26-11.16; placebo acupuncture relative risk 2.57 95% confidence interval 1.21-5.46), as well as for the subsample of occupationally active patients, all 3 modalities of acupuncture were better than conventional treatment alone, but there was no difference among the 3 acupuncture modalities, which implies that true acupuncture is not better than sham or placebo acupuncture. 相似文献
82.
Francisco Salazar Luis San FrutosVirginia Engels Beatriz BuenoTirso Pérez-Medina Inmaculada OrensanzJosé Bajo 《Progresos de Obstetricia y Ginecología》2008
Objective
To measure endometrial thickness and characterize ultrasonographic endometrial images induced by tamoxifen, as well as to determine changes in ultrasonographic patterns throughout treatment.Patients and methods
We analyzed 278 patients with breast cancer between 1995 and 2000 under adjuvant therapy with tamoxifen for 5 years. Annual ultrasonographic examination was performed. Endometrial thickness and the morphological endometrial patterns in stored ultrasonographic images were retrospectively analyzed.Results
Endometrial thickness significantly increased during treatment from a mean of 7.84 mm in the first year to 16.67 mm in the fifth year. Five endometrial patterns were found on ultrasonography in patients receiving tamoxifen: linear, heterogeneous-hyperechoic, homogeneoushyperechoic, endometrial polyp, and suspicious for malignancy. The homogeneous-hyperechoic pattern predominated in the first year and the heterogeneous-hyperechoic pattern in the fifth year.Conclusions
Tamoxifen increases endometrial thickness in the course of treatment and induces five ultrasonographic patterns which change year-by-year. 相似文献83.
84.
Martínez C García-Martín E Alonso-Navarro H Jiménez-Jiménez FJ Benito-León J García-Ferrer I Vázquez-Torres P Puertas I Zurdo JM López-Alburquerque T Agúndez JA 《Neuromolecular medicine》2007,9(2):195-204
To identify low-penetrance genes related to sporadic essential tremor (ET) at the CYP2Clocus, located in chromosome 10 q23.33. Leukocytary DNA from 200 ET patients and a control group of 300 unrelated healthy
individuals with known CYP2C19 genotypes was studied for common CYP2C8 and CYP2C9 allelic variants by using amplification-restriction analyses. Patients with ET showed the following differences compared
with healthy subjects: a 1.6-fold reduction in the frequency for CYP2C8*3 (p=0.006), a 1.35-fold reduction of CYP2C9*2 (p=0.05) and a 1.52-fold reduction in the frequency for CYP2C9*3 (p=0.07). The frequency for patients with ET carrying at least one defective allele was 1.33-fold reduced as compared with healthy
subjects (p=0.002). In addition, a disruption of the CYP2C8*3/CYP2C9*2 linkage disequilibrium was observed in ET patients, with a 2.1-fold reduction in the percentage for carriers of the haplotype
CYP2C8*3 plus CYP2C9*2 in ET patients (p=0.0001). These findings were independent of gender, age, age of onset, or clinical symptoms. These results suggest that alterations
at the CYP2C gene locus are associated with the risk for ET. 相似文献
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88.
Behrens Frank Leage Soyi Liu Sapin Christophe El Baou Celine De La Torre Inmaculada Meszaros Gabriella Schett Georg Combe Bernard van den Bosch Filip Gossec Laure 《Clinical rheumatology》2021,40(12):4955-4956
Clinical Rheumatology - 相似文献
89.
Javier Del Angel-Caraza Inmaculada Diez-Prieto Carlos César Pérez-García Ma Belén García-Rodríguez 《Urological research》2010,38(3):201-204
Effective long-term management of urolithiasis depends on identification and manipulation of factors contributing to initial
stone formation; identification of these factors depends on accurate identification of the mineral composition of the urolith
involved. The purpose of this study was to determine the chemical composition of uroliths obtained from the low urinary tract
of dogs in Mexico City. One hundred and five cases of urolithiasis were studied in which stones were surgically obtained from
the low urinary tracts of dogs treated in different hospitals. The chemical composition of the uroliths was quantitatively
and qualitatively determined by stereoscopic microscopy, IR-spectroscopy, scanning electron microscopy and X-ray microanalysis.
Age of animals ranged from 4 months to 14 years, with a median of 5 years. Composition and distribution of the uroliths were
struvite 38.1%, calcium oxalate 26.7%, silica 13.3%, urate 7.6%, mixed 11.4%, compounds 1.9%, and cystine 1%. Most uroliths
were found in pure breed dogs (75.2%); 23 different breeds were identified, and more than half of the submissions were from
breeds of small size. In our study, the frequency of struvite, calcium oxalate, cystine, urates, mixed and compounds stones
are in agreement with papers that report on dog populations in America and Europe, but a higher frequency of silica uroliths
was observed in Mexico City dogs. 相似文献
90.
Guillermina Barril Javier Bartolom Paloma Sanz Emmanuela Buoncristiani Juan Antonio Traver Rafael Selgas Umberto Buoncristiani Inmaculada Castillo Juan Antonio Quiroga Vicente Carreo 《Journal of medical virology》2010,82(5):763-767
Hemodialysis induces production of the hepatocyte growth factor (HGF) and decrease of serum hepatitis C virus (HCV) RNA in patients with HCV infection, but it is not known if the hemodialysis schedule or type of membrane affect both the HGF production and HCV viremia. The effects on both parameters of alternate‐day intermittent hemodialysis and short‐daily hemodialysis and high and low flux membranes were investigated in 41 patients treated by hemodialysis. Sixteen (39%) patients were anti‐HCV positive and 11 (69%) had HCV RNA. Twenty‐six patients were on alternate‐day intermittent and 15 on short‐daily hemodialysis. High flux membranes were used for 29 patients and low flux membranes for 12 patients. A decrease in HCV RNA was observed at the end of hemodialysis (8.6 × 105 ± 1.1 × 106 IU/ml vs. 4.4 × 105 ± 7.3 × 105 IU/ml, P = 0.003). The proportion of HCV RNA decrease was similar in patients dialyzed with both schedules and with both types of membranes. The HGF levels increased from 2,605.9 ± 1,428.7 to >8,000 pg/ml at 15 min. At the end of the session, the HGF levels decreased to 5,106.7 ± 2,533.9 pg/ml. The HGF levels at the start of the next session were similar to those at baseline (2,680.0 ± 1,209.3 pg/ml). The increase and dynamics of the HGF levels were similar in patient's hemodialyzed with both schedules and with both types of membranes. These results suggest that changes in HCV RNA and HGF levels during hemodialysis are not influenced by the schedule or type of membrane used. J. Med. Virol. 82: 763–767, 2010. © 2010 Wiley‐Liss, Inc. 相似文献