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71.
Esther Carramolino-Cuéllar Inmaculada Tomás Yolanda Jiménez-Soriano 《Medicina oral, patología oral y cirugía bucal》2014,19(3):e289-e294
The components of the human body are closely interdependent; as a result, disease conditions in some organs or components can influence the development of disease in other body locations. The effect of oral health upon health in general has been investigated for decades by many epidemiological studies. In this context, there appears to be a clear relationship between deficient oral hygiene and different systemic disorders such as cardiovascular disease and metabolic syndrome. The precise relationship between them is the subject of ongoing research, and a variety of theories have been proposed, though most of them postulate the mediation of an inflammatory response. This association between the oral cavity and disease in general requires further study, and health professionals should be made aware of the importance of adopting measures destined to promote correct oral health.
The present study conducts a Medline search with the purpose of offering an update on the relationship between oral diseases and cardiovascular diseases, together with an evaluation of the bidirectional relationship between metabolic syndrome and periodontal disease.
Most authors effectively describe a moderate association between the oral cavity and cardiovascular diseases, though they also report a lack of scientific evidence that oral alterations constitute an independent cause of cardiovascular diseases, or that their adequate treatment can contribute to prevent such diseases.
In the case of metabolic syndrome, obesity and particularly diabetes mellitus may be associated to an increased susceptibility to periodontitis. However, it is not clear whether periodontal treatment is able to improve the systemic conditions of these patients.
Key words:Cardiovascular diseases, periodontitis, metabolic syndrome, obesity, diabetes mellitus. 相似文献
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Juan C. Morilla-Herrera RN MSc PhD José M. Morales-Asencio RN BSc PhD Alberto J. Gómez-González RN MSc Antonio Díez-De Los Ríos RN Inmaculada Lupiáñez-Pérez RN MSc PhD Carlos Acosta-Andrade BSB MSc PhD Marta Aranda-Gallardo RN MSc PhD Ana B. Moya-Suárez RN MSc PhD Shakira Kaknani-Uttumchandani RN MSc PhD Silvia García-Mayor RN MSc PhD 《Journal of advanced nursing》2020,76(8):2191-2197
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Kirstin R. W. Matthews Ana S. Iltis Nuria Gallego Marquez Daniel S. Wagner Jason Scott Robert Inmaculada de Melo‐Martín Marieke Bigg Sarah Franklin Soren Holm Ingrid Metzler Matteo A. Mol Jochen Taupitz Giuseppe Testa Jeremy Sugarman 《The Hastings Center report》2021,51(1):47-51
It now seems technically feasible to culture human embryos beyond the “fourteen‐day limit,” which has the potential to increase scientific understanding of human development and perhaps improve infertility treatments. The fourteen‐day limit was adopted as a compromise but subsequently has been considered an ethical line. Does it remain relevant in light of technological advances permitting embryo maturation beyond it? Should it be changed and, if so, how and why? What justifications would be necessary to expand the limit, particularly given that doing so would violate some people's moral commitments regarding human embryos? Robust stakeholder engagement preceded adoption of the fourteen‐day limit and should arguably be part of efforts to reassess it. Such engagement could also consider the need for enhanced oversight of human embryo research. In the meantime, developing and implementing reliable oversight systems should help foster high‐quality research and public confidence in it. 相似文献
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Gemma Rojo-Martínez Sergio Valdés Natalia Colomo M. Isabel Lucena Sonia Gaztambide Ramón Gomis Roser Casamitjana Rafael Carmena Miguel Catalá María T. Martínez-Larrad Manuel Serrano-Ríos Luis Castaño Joan Vendrell Juan Girbés Josep Franch José A. Vázquez Inmaculada Mora-Peces Inés Urrutia Gemma Pascual-Manich Emilio Ortega Edelmiro Menéndez Elias Delgado Elena Bordiú Conxa Castell Alfonso López-Alba Alberto Goday Alfonso Calle Anna Bosch-Comas Federico Soriguer 《Revista espa?ola de cardiología》2013
78.
Teresa Rodríguez-Martín Inmaculada Cuchillo-Ibáñez Wendy Noble Fanon NyenyaBrian H. Anderton Diane P. Hanger 《Neurobiology of aging》2013
Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau residues on its function, wild type or phosphomutant tau was expressed in cells. Elevated tau phosphorylation decreased its microtubule binding and bundling, and increased the number of motile tau particles, without affecting axonal transport kinetics. In contrast, reducing tau phosphorylation enhanced the amount of tau bound to microtubules and inhibited axonal transport of tau. To determine whether differential tau clearance is responsible for the increase in phosphomimic tau, we inhibited autophagy in neurons which resulted in a 3-fold accumulation of phosphomimic tau compared with wild type tau, and endogenous tau was unaffected. In autophagy-deficient mouse embryonic fibroblasts, but not in neurons, proteasomal degradation of phosphomutant tau was also reduced compared with wild type tau. Therefore, autophagic and proteasomal pathways are involved in tau degradation, with autophagy appearing to be the primary route for clearing phosphorylated tau in neurons. Defective autophagy might contribute to the accumulaton of tau in neurodegenerative diseases. 相似文献
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