全文获取类型
收费全文 | 1772471篇 |
免费 | 138213篇 |
国内免费 | 6754篇 |
专业分类
耳鼻咽喉 | 22899篇 |
儿科学 | 57473篇 |
妇产科学 | 47675篇 |
基础医学 | 254425篇 |
口腔科学 | 49091篇 |
临床医学 | 159136篇 |
内科学 | 354703篇 |
皮肤病学 | 41984篇 |
神经病学 | 141004篇 |
特种医学 | 70850篇 |
外国民族医学 | 330篇 |
外科学 | 274536篇 |
综合类 | 38619篇 |
现状与发展 | 2篇 |
一般理论 | 534篇 |
预防医学 | 140844篇 |
眼科学 | 38687篇 |
药学 | 128278篇 |
5篇 | |
中国医学 | 3100篇 |
肿瘤学 | 93263篇 |
出版年
2018年 | 17609篇 |
2016年 | 16244篇 |
2015年 | 18137篇 |
2014年 | 25271篇 |
2013年 | 38088篇 |
2012年 | 47632篇 |
2011年 | 51597篇 |
2010年 | 31741篇 |
2009年 | 30714篇 |
2008年 | 48465篇 |
2007年 | 51693篇 |
2006年 | 52915篇 |
2005年 | 51062篇 |
2004年 | 49024篇 |
2003年 | 47481篇 |
2002年 | 45452篇 |
2001年 | 84503篇 |
2000年 | 87181篇 |
1999年 | 72551篇 |
1998年 | 21207篇 |
1997年 | 18821篇 |
1996年 | 20001篇 |
1995年 | 19850篇 |
1994年 | 18427篇 |
1993年 | 17432篇 |
1992年 | 59454篇 |
1991年 | 58806篇 |
1990年 | 57084篇 |
1989年 | 54661篇 |
1988年 | 50542篇 |
1987年 | 49758篇 |
1986年 | 46895篇 |
1985年 | 45199篇 |
1984年 | 34261篇 |
1983年 | 28966篇 |
1982年 | 17587篇 |
1981年 | 15948篇 |
1980年 | 14953篇 |
1979年 | 31379篇 |
1978年 | 22793篇 |
1977年 | 19238篇 |
1976年 | 17911篇 |
1975年 | 19200篇 |
1974年 | 22637篇 |
1973年 | 21549篇 |
1972年 | 20257篇 |
1971年 | 18885篇 |
1970年 | 17321篇 |
1969年 | 16323篇 |
1968年 | 15254篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
Rishad R. Jivani Gaurang J. Lakhtaria Dhaval D. Patadiya Laxman D. Patel Nurrudin P. Jivani Bhagyesh P. Jhala 《Saudi Pharmaceutical Journal》2016,24(1):1-20
Advancement in microelectromechanical system has facilitated the microfabrication of polymeric substrates and the development of the novel class of controlled drug delivery devices. These vehicles have specifically tailored three dimensional physical and chemical features which together, provide the capacity to target cell, stimulate unidirectional controlled release of therapeutics and augment permeation across the barriers. Apart from drug delivery devices microfabrication technology’s offer exciting prospects to generate biomimetic gastrointestinal tract models. BioMEMS are capable of analysing biochemical liquid sample like solution of metabolites, macromolecules, proteins, nucleic acid, cells and viruses. This review summarized multidisciplinary application of biomedical microelectromechanical systems in drug delivery and its potential in analytical procedures. 相似文献
23.
M. R. D. Maslin S. K. Lloyd S. Rutherford S. Freeman A. King D. R. Moore K. J. Munro 《Journal of the Association for Research in Otolaryngology》2015,16(5):631-640
Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in sub-cortical activity immediately before and after the onset of surgically induced unilateral deafness in adult humans. Click-evoked auditory brainstem responses (ABRs) to stimulation of the healthy ear were recorded from ten adults during the course of translabyrinthine surgery for the removal of a unilateral acoustic neuroma. This surgical technique always results in abrupt deafferentation of the affected ear. The results revealed a rapid (within minutes) reduction in latency of wave V (mean pre = 6.55 ms; mean post = 6.15 ms; p < 0.001). A latency reduction was also observed for wave III (mean pre = 4.40 ms; mean post = 4.13 ms; p < 0.001). These reductions in response latency are consistent with functional changes including disinhibition or/and more rapid intra-cellular signalling affecting binaurally sensitive neurons in the central auditory system. The results are highly relevant for improved understanding of putative physiological mechanisms underlying perceptual disorders such as tinnitus and hyperacusis. 相似文献
24.
Evaluation of Adult versus Pediatric Transesophageal Echocardiography Probe Efficiency for Guiding Septal Puncture during Atrial Fibrillation Ablation 下载免费PDF全文
25.
Dynamic LVOT Obstruction and Aortic Stenosis in the Same Patient: A Case of Challenging Doppler Hemodynamics 下载免费PDF全文
Matthew W. Parker M.D. Francis J. Kiernan M.D. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(6):1030-1032
We present a patient with both dynamic left ventricular outflow tract obstruction and valvular aortic stenosis. The aortic valve was calcified, and velocities and gradients measured by continuous‐wave Doppler met standard criteria for severe aortic stenosis. The increased subvalvular velocities invalidated assumptions of the simplified Bernoulli equation; correction using the longer form of the Bernoulli equation suggested a lower but still significant gradient. The complex shape of the subvalvular spectral Doppler envelope indicated supranormal systolic function and dynamic left ventricular outflow obstruction. Left heart catheterization with an end‐hole catheter was required to determine the subvalvular and valvular components of the obstruction. 相似文献
26.
Provocation of Atrial Fibrillation Triggers During Ablation: Does the Use of General Anesthesia Affect Inducibility? 下载免费PDF全文
27.
The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia 下载免费PDF全文
Layla D. M. Cabral Alexandre Giusti‐Paiva 《Basic & clinical pharmacology & toxicology》2016,119(5):421-427
Acute lung injury (ALI) caused by systemic inflammatory response remains a leading cause of morbidity and mortality in critically ill patients. Management of patients with sepsis is largely limited to supportive therapies, reflecting an incomplete understanding of the underlying pathophysiology. Furthermore, there have been limited advances in the treatments for ALI. In this study, lung function and a histological analysis were performed to evaluate the impact of transient receptor potential vanilloid‐1 receptor (TRPV1) antagonist (capsazepine; CPZ) on the lipopolysaccharide (LPS)‐induced lung injury in mice. For this, adult mice pre‐treated with CPZ or vehicle received intraperitoneal injections of LPS or saline and 24 hr after, the mice were anaesthetized, and lung mechanics was evaluated. The LPS‐challenged mice exhibited substantial mechanical impairment, characterized by increases in respiratory system resistance, respiratory system elastance, tissue damping and tissue elastance. The pre‐treatment with CPZ prevented the increase in respiratory system resistance and decreased the increase in tissue damping during endotoxemia. In addition, mice pre‐treated with CPZ had an attenuated lung injury evidenced by reduction on collapsed area of the lung parenchyma induced by LPS. This suggests that the TRPV1 antagonist capsazepine has a protective effect on lung mechanics in ALI during endotoxemia and that it may be a target for enhanced therapeutic efficacy in ALI. 相似文献
28.
29.
Assessment of Myocardial Infarct Size by Three‐Dimensional and Two‐Dimensional Speckle Tracking Echocardiography: A Comparative Study to Single Photon Emission Computed Tomography 下载免费PDF全文
30.
Vestibular function laboratories utilize a multitude of diagnostic instruments to evaluate a dizzy patient. Caloric irrigators, oculomotor stimuli, and rotational chairs produce a stimulus whose accuracy is required for the patient response to be accurate. Careful attention to everything from cleanliness of equipment to threshold adjustments determine on a daily basis if patient data are going to be correct and useful. Instrumentation specifications that change with time such as speed and temperature must periodically be checked using calibrated instruments. 相似文献