全文获取类型
收费全文 | 483篇 |
免费 | 42篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 43篇 |
妇产科学 | 13篇 |
基础医学 | 61篇 |
口腔科学 | 11篇 |
临床医学 | 51篇 |
内科学 | 104篇 |
皮肤病学 | 28篇 |
神经病学 | 17篇 |
特种医学 | 83篇 |
外科学 | 36篇 |
综合类 | 21篇 |
预防医学 | 9篇 |
眼科学 | 7篇 |
药学 | 21篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2021年 | 2篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2017年 | 6篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 13篇 |
2013年 | 25篇 |
2012年 | 4篇 |
2011年 | 6篇 |
2010年 | 23篇 |
2009年 | 26篇 |
2008年 | 16篇 |
2007年 | 12篇 |
2006年 | 14篇 |
2005年 | 16篇 |
2004年 | 8篇 |
2003年 | 13篇 |
2002年 | 12篇 |
2001年 | 4篇 |
1999年 | 6篇 |
1998年 | 20篇 |
1997年 | 42篇 |
1996年 | 30篇 |
1995年 | 20篇 |
1994年 | 23篇 |
1993年 | 22篇 |
1992年 | 9篇 |
1991年 | 4篇 |
1990年 | 9篇 |
1989年 | 26篇 |
1988年 | 13篇 |
1987年 | 11篇 |
1986年 | 13篇 |
1985年 | 14篇 |
1984年 | 6篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 9篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1963年 | 1篇 |
1956年 | 1篇 |
1955年 | 1篇 |
1932年 | 1篇 |
排序方式: 共有525条查询结果,搜索用时 15 毫秒
91.
Aaron E Boyce Gillian Marshman Richard AD Mills 《The Australasian journal of dermatology》2009,50(3):190-193
Erosive mucosal lichen planus (LP) is a well-established variant of LP characterized by the formation of ulcerative lesions predominantly involving the oral and genital mucosae. Less commonly, this condition may involve oesophageal and/or ocular mucosal surfaces, and case reports within the ophthalmology literature have recently confirmed the potential for this condition to affect the nasolacrimal ducts. We report the case of a woman with severe cicatrizing mucosal LP and ocular symptoms secondary to presumed nasolacrimal duct involvement. We also report the potential for this newly appreciated manifestation of LP to respond to systemic cyclosporin A. 相似文献
92.
93.
D Pathirana A Nast AD Ormerod N Reytan P Saiag CH Smith P Spuls B Rzany 《Journal of the European Academy of Dermatology and Venereology》2010,24(12):1458-1467
Background The development of evidence based guidelines is a demanding and time consuming process. Therefore it is important to share the knowledge and discuss the structure of these guidelines in detail. Objectives To present a method report on the development process of the European evidence based guidelines on the systemic treatment of psoriasis vulgaris with the aim to offer guidance to other guidelines groups with lesser experience and to critically appraise the methodology of the guidelines development process. Methods The guidelines are based on the previously evaluated literature from three European national evidence based guidelines and an additional systematic search and evaluation of new literature. Further steps included a structured consensus conference and a DELPHI procedure to develop the recommendations, as well as several internal and external reviews. All steps were coordinated by the Division of evidence based medicine in cooperation with a group of methodologists. Results A total of 114 studies were included, serving as base for the efficacy chapters of the intervention. The recommendations, based on the efficacy and the level of evidence of the included studies were discussed and finally consented by the guidelines group. After subsequent reviews the guidelines were presented to the European Dermatology Forum, European Academy of Dermatology and Venereology and Union Européenne des Médicins Spécialistes for approval and published in October 2009. Conclusion The development of European evidence based guidelines requires a coordinated structure which can be achieved by the integration of an experienced group of methodologists. Nevertheless further improvements are imaginable and might be considered for an update or other European evidence based guidelines. 相似文献
94.
S Birkenfeld J Dreiher D Weitzman AD Cohen 《Journal of the European Academy of Dermatology and Venereology》2011,25(4):436-440
Background Previous reports have demonstrated contradicting results on the association between lichen planus and hepatitis. Objectives The aim of this study was to investigate the association between lichen planus and viral hepatitis. Methods Patients with lichen planus were compared with controls regarding the prevalence of viral hepatitis in a case‐control study using logistic multivariate regression models. The study was performed utilizing the medical database of Clalit Health Services. Results The study included 1557 lichen planus patients over the age of 20 years and 3115 age‐ and gender‐matched controls. The prevalence of hepatitis C in patients with lichen planus was higher than that in the control group (1.9%, 0.4% respectively, P < 0.001). In a multivariate analysis, lichen planus was associated with hepatitis C (OR 4.19, 95% CI 2.21; 7.93). The prevalence of hepatitis B in patients with lichen planus was similar to that in the control group (0.9%, 0.5% respectively, P = 0.12). A multivariate analysis revealed that lichen planus was not associated with hepatitis B (OR 1.69, 95% CI 0.82; 3.47). Conclusion Lichen planus is associated with hepatitis C but not with hepatitis B. Physicians who care for patients with lichen planus should consider screening patients with lichen planus for hepatitis C. 相似文献
95.
96.
采用RITQ综合评定婴儿气质的报告 总被引:2,自引:0,他引:2
张琪 《中国心理卫生杂志》1997,11(3):155-157
采用Carey的RITQ为4-8个月婴儿气质的测查工具,结合专人问卷与观察,对400名婴儿的气质进行了综合评定,结果表明:九个气质因子的重测信度为0.77-0.90,多数气质因子间存在着显著的相关,相关系数为0.10-0.59。大、小婴儿活动水平、接近-退缩、适应及反应强度四个气质因子存在差异。气质类型与国外同龄婴儿及国内学前儿童的分布相接近。提示采用RITQ综合评定婴儿气质的信度和效度较好,可用于我国婴儿的气质测查及研究。 相似文献
97.
Safety of outpatient peripheral angioplasty 总被引:2,自引:0,他引:2
98.
99.
Summary— Beta-adrenergic receptors (β/-AR) belong to the large multigenic family of receptors coupled to GTP-binding proteins. Three subtypes have been identified: β1 -, β2 - and β3 -AR. Much of the work delineating the precise pharmacological comparison of the three β-ARs has come from investigations with stably transfected Chinese hamster ovary cells (CHO cells). This review discusses the structure and function of β3 -AR in various species and presents new findings on a number of β3 -AR ligands including carazolol, tertatolol and CL 316,243 which were found to be selective and potent β3 -AR agonists and ZD 2079 and salmeterol which appear to display full but non-subtype selective agonistic activity. Species-related variations of the β3 -AR pharmacology have been shown for propranolol and bupranolol. With the ongoing characterization of the β3 -AR at the molecular and cellular level, and with the advent of computer-assisted molecular modelling to aid in the determination of the three-dimensional structure of the receptor, it is thought that novel β3 -AR compounds will become available with improved selectivity and potency. 相似文献
100.
IM Balfour-Lynn B Valman M Silverman AD Webster 《Archives of disease in childhood》1993,68(4):472-476
It is unknown why some infants wheeze during upper respiratory tract infections. One possibility is that secretory IgA, which has a major role in mucosal defence against viral infection, might be deficient in wheezy infants. The nasal IgA response to upper respiratory tract infection in 32 wheezy infants (median age 5.8 months) was compared with nine siblings (median age 2.6 years) who had nasal symptoms only. Nasal lavage was performed during infections and on follow up when free from symptoms, using inulin as a marker of dilution to determine absolute concentrations of IgA in the nasal secretions. The two groups showed a similar increase in total IgA and total protein levels during infection, but secretory IgA concentrations were unchanged. This study shows that wheezy infants have a normal nasal IgA response to infection and that the increase in total IgA during early infection is due to plasma exudation rather than increased production of secretory IgA. 相似文献