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311.
Huttunen R Aittoniemi J Laine J Vuento R Karjalainen J Rovio AT Eklund C Hurme M Huhtala H Syrjänen J 《Scandinavian journal of immunology》2008,68(4):438-444
Mannose-binding lectin (MBL) insufficiency caused by point mutations in the MBL2 gene has been associated with increased susceptibility to bacteraemic infections. We here investigated the effect of MBL2 polymorphisms on the susceptibility and clinical course of bacteraemia. The study cohort comprised 145 patients with bacteraemia and 400 controls. In the case of patients with bacteraemia, laboratory findings and clinical data were registered on admission and during six consecutive days. MBL2 structural polymorphisms at codons 52 (CGT→TGT; designated D or O), 54 (GGC→GAC; B or O) and 57 (GGA→GAA; C or O) in exon 1 of the MBL2 gene and promoter region polymorphisms at position −221 (G→C, designated Y or X alleles) were determined. No difference in MBL2 genotype frequencies between the bacteraemic patients and controls was detected, and MBL2 genotype had no independent effect on mortality, nor disease severity. However, smoking proved a significant risk factor for Gram-positive ( Staphylococcus aureus , Streptococcus pneumoniae or β-haemolytic streptococci) bacteraemia in patients carrying the variant O allele (53% current smokers in Gram-positive bacteraemia patients compared with only 21% in controls, odds ratios 4.2, 95% confidence intervals 2.0–9.0; P < 0.001), while it did not have an effect in those homozygous for the A allele. The same effect was not detected in Escherichia coli bacteraemia. In conclusion, MBL2 genotypes representing MBL insufficiency were not associated with the overall risk of bacteraemia or disease severity, but smoking in carriers of the structural variant O allele may have a deleterious effect increasing the risk of Gram-positive bacteraemia. 相似文献
312.
Kananen Laura Hurme Mikko Bürkle Alexander Moreno-Villanueva Maria Bernhardt Jürgen Debacq-Chainiaux Florence Grubeck-Loebenstein Beatrix Malavolta Marco Basso Andrea Piacenza Francesco Collino Sebastiano Gonos Efstathios S. Sikora Ewa Gradinaru Daniela Jansen Eugene H. J. M. Dollé Martijn E. T. Salmon Michel Stuetz Wolfgang Weber Daniela Grune Tilman Breusing Nicolle Simm Andreas Capri Miriam Franceschi Claudio Slagboom Eline Talbot Duncan Libert Claude Raitanen Jani Koskinen Seppo Härkänen Tommi Stenholm Sari Ala-Korpela Mika Lehtimäki Terho Raitakari Olli T. Ukkola Olavi Kähönen Mika Jylhä Marja Jylhävä Juulia 《Age (Dordrecht, Netherlands)》2023,45(1):85-103
GeroScience - Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes... 相似文献
313.