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101.
102.
Autoantibodies and immunoglobulin allotypes in healthy North American Blacks of different age groups
TH. Ockhuizen J.P. Pandey G.M.P. Galbraith H.H. Fudenberg C.G. Hames 《Mechanisms of ageing and development》1982,19(2):103-111
A population of 291 healthy North American Black subjects of different ages was studied for immunoglobulin (Ig) allotypes and the prevalence of autoantibodies, to determine possible associations between Ig allotypes and age, autoantibodies and age, and Ig allotypes and autoantibodies. Indirect immunofluorescence was used to detect anti-gastric parietal cell, anti-smooth muscle, anti-thyroid microsomal, anti-nuclear, and anti-mitochondrial antibodies. The sera were typed for the Ig allotypes Gm(1, 2, 3, 5, 6, 13, 14, 17, and 21) and Km(1) with a hemagglutination-inhibition assay. A significant association between advanced age and an increased prevalence of anti-nuclear antibodies was observed in females. There was no significant association between Ig allotypes and the autoantibodies tested. The results suggest that Ig allotypes are not involved in the development of autoantibodies in healthy Blacks. 相似文献
103.
104.
Acetylcarbocholine and acetylsilicocholine: Directly or indirectly acting cholinergic spasmogens? 总被引:1,自引:0,他引:1
P. TH. HENDERSON E. J. ARIËNS B. W. J. ELLENBROEK A. M. SIMONIS 《The Journal of pharmacy and pharmacology》1968,20(1):26-35
The cholinergic and anticholinergic actions of nitrogen-free isosteres of acetylcholine and benzilylcholine are described. Esters of two kinds of choline analogues, carbocholine and silicocholine, were used. The spasmogenic activity of acetylcarbocholine and acetylsilicocholine on the guinea-pig ileum was identified as an indirect cholinergic action, in contrast to the direct cholinergic action of furtrethonium and the mainly non-cholinergic action of barium ions. In addition to this indirect cholinergic action, both esters show a weak anticholinergic and a weak noncompetitive “papaverine-like” spasmolytic activity. The corresponding benzilyl esters, although without an onium group, are relatively potent anticholinergic compounds. 相似文献
105.
C. DACOU-VOUTETAKIS TH. THOMAIDIS E. ROMA A. KALPINI-MAVROU C. ECONOMOU-MAVROU 《Acta paediatrica (Oslo, Norway : 1992)》1975,64(5):773-776
ABSTRACT: Dacou-Voutetakis, C. Thomaidis, Th., Roma, E., Katpini-Mavrou, A. and Economou-Mavrou, C. (First Department of Paediatrics, Athens University, Greece). Systemic allergic reaction to initial insulin therapy in a juvenile diabetic. Enhanced blast transformation to insulin. Acta Paediatr Scand, 64: 773, 1975–A 14-year-old girl with recent onset of diabetes developed a severe systemic allergic reaction to beef-pork insulin on the third day of insulin therapy. The same reaction developed following the injection of pork insulin and monocomponent insulin. The patient was induced to tolerate pork insulin by systemic de-sensitization to this insulin over an interval of 6 days. Peripheral blood lymphocytes from the patient cultured in the presence of insulin responded by increased blast cell transformation, as compared with controls, who either had previously presented local allergic reactions to insulin or never had manifested insulin allergy. 相似文献
106.
ZIAD DAHDOUH M.D. VINCENT ROULE M.D. AUDREY EMMANUELLE DUGUÉ M.D. RÉMI SABATIER M.D. THÉRÈSE LOGNONÉ M.D. GILLES GROLLIER M.D. 《Journal of interventional cardiology》2013,26(2):173-182
Objectives
The aim of this study was to appreciate the safety and effectiveness of transradial percutaneous coronary intervention (PCI) with rotational atherectomy for highly calcified left main coronary artery (LMCA) disease in octogenarians.Background
Conventional surgery is still considered the preferred management for LMCA disease; but, when the lesion is severely calcified, and the patient is unsuitable for surgery, the interventional cardiologist faces a complex PCI traditionally approached by femoral access.Methods
Between June 2004 and December 2010, octogenarians with calcified LMCA disease who were primary denied for surgical revascularization were enrolled. Procedural success and major adverse cerebral and cardiovascular events (MACCE) including death, nonfatal myocardial infarction, target lesion revascularization (TLR), or stroke during long‐term follow‐up were evaluated.Results
Forty‐two consecutive patients≥80 years had undergone stenting for calcified LMCA disease (13 with rotational atherectomy, the “Rota” group, and 29 without rotational atherectomy, the “without Rota” group). Procedural success was good (92.3% vs. 96.6%, respectively, p = NS). Mean follow‐up time was 25.7 ± 21.4 and 28 ± 32.3 months, respectively. There was a TLR in 25% and 11.1%, respectively; p = NS. No difference was detected in terms of overall in‐hospital or long‐term mortality or MACCE.Conclusion
Rotational atherectomy followed by stent implantation by transradial approach, when applied to heavily calcified lesions, appeared to be a safe and effective strategy for the treatment of LMCA disease in octogenarians who were refused for surgery. (J Interven Cardiol 2013;26:173–182)107.
Background
Regular exposure to tobacco smoke at home causes airway inflammation and altered cytokine regulation; however, there is variation between individuals of different countries.Objective
To determine effects of passive smoking on plasma IL4, TNFá, and CRP in healthy male school-children in Khartoum.Methods
A total of 135 male school-pupils (69 passive smokers and 66 non-smokers) were selected randomly from three primary schools for boys in Khartoum. Information about smoking history was collected from each pupil and his parents using a questionnaire. Plasma CRP, IL4 and TNFá were measured using commercially available ELISA kits.Results
Plasma IL4 and TNFá in the passive smokers (mean ± SEM) is at 2.92 ± 0.93 and 19.78 ± 4.67 pg/ml respectively; whereas in the non-smokers . It is at 0.45 ± 0.28 and 5.05 ± 1.54 pg/ml respectively. The difference between the two groups is statistically significant (p <0.05). The mean plasma IL4 and TNFá were lowest with no exposure, higher with moderate exposure, and highest with heavy exposure (P < 0.05). Plasma CRP showed insignificant difference between the two groups.Conclusion
Passive smoking causes significant rise in plasma TNFá and IL4 with a dose dependent effect among school-pupils in Khartoum. 相似文献108.
This study investigated correlates of quality of life (QOL) among people living with HIV/AIDS (PLWH) at An Hoa Clinic, Ho Chi Minh City, Vietnam. Inclusive criteria were PLWH ≥18 years old, under antiretroviral therapy (ART) for ≥3 months, and consent to participate. PLWH who were illiterate, too ill, or at the final stage of AIDS were excluded. QOL was assessed using WHOQOL-BREF-HIV. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. For every point increased in depression score, QOL decreased 0.13 points in Physical (p?<?.001), 0.12 points in Psychological and Social Relationships (p?<?.001), 0.07 points in Level of Independence (p?<?.001), 0.09 points in Environment (p?<?.001), and 0.15 points in Personal Beliefs domain (p?<?.001). PLWH from an economically disadvantaged household had lower QOL scores for all QOL domains but Personal Beliefs with differences ranging from 0.81 points for Social Relationships to 1.77 points for Environment domain. PLWH with a co-morbidity had lower scores whereas those living with a spouse and adhering to ART medication had higher scores in at least one QOL domain. In conclusion, depressive symptoms, household economy, living with a spouse, having a co-morbidity and ART medication adherence were important factors associated with PLWH’s QOL. 相似文献
109.
Jasgurpreet Singh Chohan Raman Kumar TH Bhatia Singh Sandeep Singh Shubham Sharma Jujhar Singh Mozammel Mia Danil Yurievich Pimenov Somnath Chattopadhyaya Shashi Prakash Dwivedi Wojciech Kaponek 《Materials》2020,13(22)
Despite several additive manufacturing techniques are commercially available in market, Fused Deposition Modeling (FDM) is increasingly used by researchers and engineers for new product development. FDM is an established process with a plethora of advantages, but the visible surface roughness (SR), being an intrinsic limitation, is major barrier against utilization of fabricated parts for practical applications. In the present study, the chemical finishing method, using vapour of acetone mixed with heated air, is being used. The combined impact of orientation angle, finishing temperature and finishing time has been studied using Taguchi and ANOVA, whereas multi-criteria optimization is performed using the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). The surface finish was highly responsive to increase in temperature while orientation angle of 0° yielded maximum strength; increase in finishing time led to weight gain of FDM parts. As the temperature increases, the percentage change in surface roughness increases as higher temperature assists the melt down process. On the other hand, anisotropic behaviour plays a major role during tensile testing. The Signal-to-noise (S/N) ratio plots, and ANOVA results indicated that surface finish is directly proportionate to finishing time because a longer exposure results in complete layer reflowing and settlement. 相似文献
110.
From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells 总被引:25,自引:0,他引:25 下载免费PDF全文
Shuyuan Yeh Hui-Kuan Lin Hong-Yo Kang Tin Htwe Thin Ming-Fong Lin Chawnshang Chang 《Proceedings of the National Academy of Sciences of the United States of America》1999,96(10):5458-5463
Overexpression of the HER2/Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu. Using AG879, a HER2/Neu inhibitor, and PD98059, a MAP kinase inhibitor, as well as MAP kinase phosphatase-1 (MPK-1), in the transfection assay, we found that HER2/Neu could induce prostate-specific antigen (PSA), a marker for the progression of prostate cancer, through the MAP kinase pathway at a low androgen level. Reporter assays and mammalian two-hybrid assays further suggest this HER2/Neu-induced androgen receptor (AR) transactivation may function through the promotion of interaction between AR and AR coactivators, such as ARA70. Furthermore, we found this HER2/Neu --> MAP kinase --> AR-ARAs --> PSA pathway could not be blocked completely by hydroxyflutamide, an antiandrogen used in the treatment of prostate cancer. Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients. 相似文献