全文获取类型
收费全文 | 664798篇 |
免费 | 40403篇 |
国内免费 | 959篇 |
专业分类
耳鼻咽喉 | 8966篇 |
儿科学 | 20993篇 |
妇产科学 | 17052篇 |
基础医学 | 107107篇 |
口腔科学 | 19703篇 |
临床医学 | 53294篇 |
内科学 | 126833篇 |
皮肤病学 | 16314篇 |
神经病学 | 48710篇 |
特种医学 | 22043篇 |
外国民族医学 | 63篇 |
外科学 | 94300篇 |
综合类 | 9226篇 |
一般理论 | 142篇 |
预防医学 | 56892篇 |
眼科学 | 16210篇 |
药学 | 52378篇 |
中国医学 | 1631篇 |
肿瘤学 | 34303篇 |
出版年
2021年 | 5394篇 |
2019年 | 6093篇 |
2018年 | 9585篇 |
2017年 | 6573篇 |
2016年 | 7003篇 |
2015年 | 7805篇 |
2014年 | 9648篇 |
2013年 | 15013篇 |
2012年 | 22488篇 |
2011年 | 24349篇 |
2010年 | 13284篇 |
2009年 | 11406篇 |
2008年 | 21920篇 |
2007年 | 23597篇 |
2006年 | 23400篇 |
2005年 | 22476篇 |
2004年 | 21537篇 |
2003年 | 20359篇 |
2002年 | 19906篇 |
2001年 | 28232篇 |
2000年 | 29646篇 |
1999年 | 24000篇 |
1998年 | 6097篇 |
1997年 | 5137篇 |
1996年 | 5468篇 |
1995年 | 4997篇 |
1992年 | 17646篇 |
1991年 | 18065篇 |
1990年 | 18168篇 |
1989年 | 17274篇 |
1988年 | 15993篇 |
1987年 | 15748篇 |
1986年 | 14916篇 |
1985年 | 14208篇 |
1984年 | 10533篇 |
1983年 | 9038篇 |
1979年 | 10474篇 |
1978年 | 7570篇 |
1977年 | 6475篇 |
1976年 | 6262篇 |
1975年 | 7182篇 |
1974年 | 8610篇 |
1973年 | 8138篇 |
1972年 | 7960篇 |
1971年 | 7653篇 |
1970年 | 7070篇 |
1969年 | 6833篇 |
1968年 | 6539篇 |
1967年 | 5887篇 |
1966年 | 5248篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
41.
Andres Eduardo Campuzano-García Bertha Torres-Alvarez Diana Hernández-Blanco 《Journal of cosmetic and laser therapy》2015,17(4):213-215
Hailey–Hailey disease (HHD), also known as benign familial pemphigus, is an autosomal dominant skin condition that affects the adhesion of epidermal keratinocytes. Although the initial manifestation of flaccid vesicles on erythematous or normal skin in flexure sites frequently goes unnoticed, large, macerated, exudative plaques of superficial erosions with crusting are observed at the time of diagnosis. There is no specific treatment for HHD, and most cases are symptomatically supported. However, infrared laser ablation has been somewhat helpful. We present a case successfully treated with fractional CO2 laser showing a long-term favourable outcome and no adverse effects. Thus, this modality could be an alternative to full ablation for this condition. 相似文献
42.
43.
Alejandra Gordillo Hernández Eduardo Dominguez-Adame Lanuza Auxiliadora Cano Matias Rosario Perez Huertas Katherine Maria Gallardo Rodriguez Purificacion Gallinato Perez Fernando Oliva Mompean 《World journal of gastrointestinal surgery》2015,7(8):170-173
Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence. 相似文献
44.
Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features
下载免费PDF全文
![点击此处可从《Histopathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
45.
46.
47.
48.
Feasibility and Diagnostic Potential of Pulmonary Transit Time Measurement by Contrast Echocardiography: A Pilot Study
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
49.
E. M. Peterman C. Sullivan M. F. Goody I. Rodriguez-Nunez J. A. Yoder C. H. Kim 《Infection and immunity》2015,83(1):430-440
Mitochondria are known primarily as the location of the electron transport chain and energy production in cells. More recently, mitochondria have been shown to be signaling centers for apoptosis and inflammation. Reactive oxygen species (ROS) generated as by-products of the electron transport chain within mitochondria significantly impact cellular signaling pathways. Because of the toxic nature of ROS, mitochondria possess an antioxidant enzyme, superoxide dismutase 2 (SOD2), to neutralize ROS. If mitochondrial antioxidant enzymes are overwhelmed during severe infections, mitochondrial dysfunction can occur and lead to multiorgan failure or death. Pseudomonas aeruginosa is an opportunistic pathogen that can infect immunocompromised patients. Infochemicals and exotoxins associated with P. aeruginosa are capable of causing mitochondrial dysfunction. In this work, we describe the roles of SOD2 and mitochondrial ROS regulation in the zebrafish innate immune response to P. aeruginosa infection. sod2 is upregulated in mammalian macrophages and neutrophils in response to lipopolysaccharide in vitro, and sod2 knockdown in zebrafish results in an increased bacterial burden. Further investigation revealed that phagocyte numbers are compromised in Sod2-deficient zebrafish. Addition of the mitochondrion-targeted ROS-scavenging chemical MitoTEMPO rescues neutrophil numbers and reduces the bacterial burden in Sod2-deficient zebrafish. Our work highlights the importance of mitochondrial ROS regulation by SOD2 in the context of innate immunity and supports the use of mitochondrion-targeted ROS scavengers as potential adjuvant therapies during severe infections. 相似文献