头痛宁治疗偏头痛效果及安全性的Meta分析

目的 评价头痛宁胶囊治疗偏头痛的临床效果.方法 计算机检索维普、中国生物医学文献数据库、中国知网、万方数据库进行资料收集,筛选2001年1月1日～2014年6月1日间所有使用头痛宁与西药治疗偏头痛的随机对照试验(RCT),同时手动检测其参考文献.采用Jadad7分评分法评价纳入文献质量,由2名评价者独立进行文献质量评价和资料提取后,采用RevMan 5.0软件进行Meta分析.结果 检出符合标准RCT文献共144篇,筛选出10项研究(中药组602例,西药组566例)进行Meta分析.头痛宁治疗偏头痛效果与西药比较,其总OR=1.19,95％CI为(1.12,1.27);在治愈率方面,OR=1.61,其95％CI为(1.24,2.09);在安全性方面,其不良反应出现OR=1.64,95％CI为(0.29,0.90).结论 头痛宁治疗偏头痛效果确切,比西药单纯治疗效果好,两者合用可能取得更好的效果,但尚需更多高质量的研究以增加证据的强度.     

唐山地区野生药用植物资源开发利用价值评价初步研究简

目的：评价唐山地区的野生药用植物资源的开发利用价值,为药用植物资源的综合开发利用提供依据。方法：在药用植物资源调查的基础上,采用系统工程论中的层次分析法定量评价唐山地区野生药用植物资源的开发利用价值,筛选出可供开发利用的药用植物资源。结果：初步调查及评价结果显示唐山地区可供开发利用的药用植物资源有62种。结论：唐山地区可供开发利用的野生药用植物资源丰富,应制定综合开发利用及保护规划,综合开发利用各药用植物资源,并保持生态资源的可持续发展。     

Induction of bone formation in biphasic calcium phosphate scaffolds by bone morphogenetic protein‐2 and primary osteoblasts

Bone tissue engineering strategies mainly depend on porous scaffold materials. In this study, novel biphasic calcium phosphate (BCP) matrices were generated by 3D‐printing. High porosity was achieved by starch consolidation. This study aimed to characterise the porous BCP‐scaffold properties and interactions of osteogenic cells and growth factors under in vivo conditions. Five differently treated constructs were implanted subcutaneously in syngeneic rats: plain BCP constructs (group A), constructs pre‐treated with BMP‐2 (group B; 1.6 µg BMP‐2 per scaffold), seeded with primary osteoblasts (OB) (group C), seeded with OB and BMP‐2 (group D) and constructs seeded with OB and pre‐cultivated in a flow bioreactor for 6 weeks (group E). After 2, 4 and 6 weeks, specimens were explanted and subjected to histological and molecular biological analyses. Explanted scaffolds were invaded by fibrovascular tissue without significant foreign body reactions. Morphometric analysis demonstrated significantly increased bone formation in samples from group D (OB + BMP‐2) compared to all other groups. Samples from groups B‐E displayed significant mRNA expression of bone‐specific genes after 6 weeks. Pre‐cultivation in the flow bioreactor (group E) induced bone formation comparable with group B. In this study, differences in bone distribution between samples with BMP‐2 or osteoblasts could be observed. In conclusion, combination of osteoblasts and BMP‐2 synergistically enhanced bone formation in novel ceramic scaffolds. These results provide the basis for further experiments in orthotopic defect models with a focus on future applications in orthopaedic and reconstructive surgery. Copyright © 2012 John Wiley & Sons, Ltd.     

2009年内蒙古自治区盟(市)、旗县(区)两级健康教育机构与人力资源现状调查

目的了解2009年内蒙古盟市、旗县(区)两级健康教育机构与人力资源现状。方法采用《2009年健康教育所(中心)业务工作调查表及基本情况调查表》(卫统46表)对内蒙古盟市、旗县(区)两级健康教育机构设置、人力资源、经费和活动形式进行问卷调查。结果全区12个盟市中有7个盟市级健康教育所为独立建制;104个旗县(区)均有健康教育机构,其中有20个为独立建制。盟市、旗县(区)两级分别有专职健康教育人员73人和190人,两级机构人员学历以本科(40.7%)和大专(39.5%)为主,职称构成均以中级(36.5%)和初级(39.16%)为主,医学背景(公共卫生或临床医学)人员比例仅为人员总数的32.3%。两级健康教育机构的经费主要来源于财政拨款,健康教育机构的工作形式主要有印刷小册子、折页、宣传画、举办健康知识讲座等。结论内蒙古自治区健康教育存在管理体制不顺,专业人员数量偏少、整体素质偏低,财政投入不足,活动形式过于老化与单一等突出问题,需要在医药卫生体制改革中得到解决。     

唐山产桑叶中桑叶多糖对2型糖尿病大鼠糖代谢及脂代谢影响

目的：研究桑叶多糖对实验性2型糖尿病（T2DM）模型大鼠糖代谢及脂代谢的影响。方法：大鼠高糖高脂饲料喂养4周后,腹腔注射30mg·kg^-1链脲佐菌素（STZ）,建立T2DM大鼠模型,随机分为糖尿病模型对照组、桑叶多糖低剂量组（灌胃180mg·kg^-1·d^-1）、中剂量组（灌胃360mg·kg^-1·d^-1）、高剂量组（灌胃540mg·kg^-1·d^-1）及罗格列酮治疗组（灌胃4mg·kg·d^-1）。持续灌胃给药60d后测空腹血糖（FBG）、血脂、糖化血红蛋白（HbAlc）、胰岛素（Ins）的含量。结果：桑叶多糖可降低T2DM模型大鼠的FBG、HbAlc、总胆固醇（TCH）、甘油三酯（TG）及低密度脂蛋白（LDL）水平,提高高密度脂蛋白（HDL）和Ins水平,与模型组比较有明显改善（P〈0．05）,与罗格列酮药物治疗组无显著性差异（P〉0．05）。结论：桑叶多糖能有效地降低T2DM模型大鼠的血糖,促进胰岛素（Ins）分泌．纠正糖尿病大鼠脂代谢紊乱．调节血脂。     

FS02.6Patch test reactivity to nickel sulphate and fragrance mix in unselected children

Aim:  To investigate the occurrence of hand eczema after 20 years in schoolgirls previously patch‐tested to nickel.
Methods:  In 1982–83, 960 schoolgirls, aged 8, 11 and 15 years, were investigated for the occurrence of nickel allergy (Larson‐Stymne B and Widström L, Contact Dermatitis 1985:13:289–293). The girls were patch‐tested and the prevalence of nickel allergy was 9%. Twenty years later, the same individuals have received a questionnaire regarding hand eczema and factors of importance for the development of hand eczema. After two reminders, the response rate was 81%.
Results:  In total 17.5% of the girls reported hand eczema after the age of 15. The 1‐year prevalence of hand eczema was 12.6%. Of the previously patch‐tested schoolgirls who answered the questionnaire, 63 were sensitive to nickel. In this study, the prevalence of hand eczema among those 63 was 16%, compared to 17% in the non‐sensitive group (NS). Excluding persons with atopic dermatitis, the prevalence of hand eczema was 12.5% in the nickel‐sensitive group, and 10% among the others (NS). 32% of the persons who had had atopic dermatitis reported hand eczema after 15 years of age, compared to 10% of those with no history of atopic dermatitis (p < 0.001).
Conclusion:  Contact allergy to nickel in early childhood (8–15 years) did not seem to increase the prevalence of hand eczema later in life. The prevalence of hand eczema was increased by a factor of three among those with a history of atopic dermatitis, which is in accordance with earlier reports.     

Lipomatous meningioma: Characteristic computed tomographic appearance

A case of lipomatous meningioma is reported. This is a rare variant of meningioma in which metaplasia of meningoepithelial cells occurs and mature adipocytes are present within the tumour. The heterogeneous attenuation and heterogeneous enhancement visualized on computed tomography (CT) can mimic necrotic malignant tumours. However, the demonstration of fat attenuation within the tumour explains the heterogeneity and suggests a benign process. The differential diagnosis of an extra-axial fat-containing tumour should include lipomatous meningioma.