曝气式微电解处理PCB显影脱膜预处理废水的试验研究

文章对印制电路板显影脱膜废水进行试验研究,提出采用曝气式微电解处理显影脱膜废水酸析后预处理的工艺,通过正交试验和单因素试验相互验证工艺参数,并获得最佳工艺参数:铁炭比1∶1,pH值3.0,反应时间60 min,CODCr的去除率达到60%左右,重金属等指标低于检出限。     

静脉用更昔洛韦在治疗婴儿巨细胞病毒感染中的不良反应

巨细胞病毒（Cytomegalovirus,CMV）是新生儿感染的重要病原之一,曾有学者对1996-2006年MEDLINE数据库中有关婴幼儿巨细胞病毒感染的流行病学资料进行Meta分析发现,活产婴儿中先天性巨细胞病毒感染的患病率约为0.64%,其中约11%的患儿出现临床症状[1]。     

Ultrasound-Based Carotid Plaque Characteristics Help Predict New Cerebral Ischemic Lesions after Endarterectomy

The aim of this study was to identify the ultrasound-based carotid plaque characteristics associated with new cerebral ischemic lesions after carotid endarterectomy (CEA). Between January 2013 and December 2018, carotid duplex ultrasound was performed in 1061 patients who underwent CEA. Brain magnetic resonance diffusion-weighted imaging (DWI) was performed pre-operatively and within 30 d after CEA. New cerebral ischemic lesions on DWI were observed in 169 patients. The cutoff value gray-scale median (GSM) used to distinguish DWI-positive from DWI-negative patients was 30.5, with an area under the receiver operating characteristic curve of 0.837. A larger proportion of multiple DWI lesions were observed in the GSM ≤30.5 group (59.5% vs. 41.5%, p = 0.030). Univariate and multivariate analyses identified GSM ≤30.5, ulcerated carotid plaques and pre-operative ischemic symptoms as predictors of post-operative cerebral DWI lesions. Our results indicate that ultrasound-based carotid plaque characteristics help predict new cerebral ischemic lesions after CEA.     

伊贝母异甾体生物碱通过Wnt/β-catenin信号通路调节哮喘大鼠气道炎症和气道重塑机制的研究

目的 探讨伊贝母异甾体生物碱对哮喘大鼠气道炎症、气道重塑及Wnt/β-catenin信号通路的影响。方法 本研究采用吸入卵清蛋白（OVA）致敏和激发的方法建立大鼠哮喘模型，连续给予药物7天；抽取支气管肺泡灌洗液（BALF）进行白细胞分类计数，酶联免疫吸附法（ELISA）检测BALF中白介素4（IL-4）、白介素5（IL-5）和白介素13（IL-13）的水平；取肺组织进行苏木精-伊红（HE）染色，观察药物对哮喘大鼠气道重塑的影响；采用Western blot技术考察异甾体生物碱对Wnt/β-catenin信号通路上Wnt5a、Wnt7b和β-catenin蛋白的调节作用。结果 与模型组比较，异甾体生物碱组大鼠肺泡间质炎性细胞浸润和支气管管腔狭窄均显著改善，支气管壁厚度和平滑肌厚度均明显降低；Western blot结果显示异甾体生物碱对于哮喘大鼠Wnt/β-catenin通路上的Wnt5a、Wnt7b和β-catenin蛋白表达均有显著的调节作用。结论 异甾体生物碱对于哮喘相关的病理变化-炎症和气道重塑均有一定的治疗作用，且该治疗作用与Wnt/β-catenin信号通路有关。     

应用PDCA循环法提高急诊检验项目全程TAT达标率

目的应用PDCA循环法缩短急诊项目的全程结果回报时间(TAT)。方法回顾性分析2017年1-12月(PDCA循环法实施前)深圳市罗湖医院集团妇科、产科急诊项目[血常规、凝血、离子七项、血人绒毛膜促性腺激素(HCG)+孕酮]的TAT未达标率。2018年应用PDCA管理工具,绘制鱼骨图分析原因、柏拉图真因确定、甘特图制订计划,利用5W1H法制订对策,并进行对策实施。同时,购置仪器、人员培训、规范化工作流程、加强临床沟通协调。对2017年1-12月(实施前)与2018年1-6月(实施后)的急诊报告时间达标率进行比较。结果2018年1—6月,急诊项目血常规、凝血、离子七项、血HCG+孕酮申请至采样时间达标率较2017年1—12月分别上升了4.89%、4.53%、6.94%、3.63%;采样至核收时间达标率分别上升了13.33%、13.57%、37.1%、13.95%;核收至发送时间达标率分别上升了20.85%、5.96%、5.01%、6.31%。应用PDCA前后申请至采样时间、采样至核收时间、核收至发送时间,差异均有统计学意义(χ2=11.325、19.569、5.301,P<0.001)。结论应用PDCA循环法对急诊检验项目TAT达标率进行质量改进、人员培训、标准化交接班制度制订,优化标本送检流程,标本高峰期增加运送人员,保障检测仪器的质量,进一步完善了信息系统,加强了与临床的沟通、协调,可以提高急诊项目全程TAT达标率,有效缩短结果TAT。     

Bioaccumulation of PBDE congener 2,2′,4,4′-tetrabromodiphenyl ether by Heterosigma akashiwo in response to different nutrient concentrations

Changes in the bioaccumulation of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in the marine alga Heterosigma akashiwo (Raphidophyceae) were examined for different concentrations of nitrate (0, 128, and 512 μmol dm^?3) and phosphate (0, 8, and 32 μmol dm^?3) in the semi-continuous culture with 20% renewal rate. The BDE-47 content per cell and per culture, as well as the accumulated percentage of available BDE-47, presented a significant decreasing trend with the increase in nitrate and phosphate concentrations. The N-0 (4.0 × 10^?6 ng cell^?1) and P-0 (5.8 × 10^?6 ng cell^?1) treatments had significantly higher BDE-47 content per cell than other treatments. In comparison, the difference in BDE-47 per algal culture and accumulated percentage between the nitrate treatments or phosphate treatments was not as obvious as the BDE-47 content per cell. BDE-47 per cell presented significantly negative correlation with nitrate and phosphate concentrations, and the accumulated BDE-47 was in positive correlation with lipid content. log BAF_lip for BDE-47 in H. akashiwo ranged from 6.70 to 7.25. The results of this study indicate that variation in BDE-47 accumulation by H. akashiwo corresponds to the change in cellular lipid content induced by different nitrate and phosphate concentrations.