颅颌面形态有限元分析系统的初步建立

初步建立一个用于颅颌面形态变化研究的有限元分析系统。方法：程序用ＢｏｒｌａｎｄＣ语言编写，对临床常用的Ｘ线头颅定位片进行分析，将呆分析的头颅定位片描在硫酸纸上，用图形数值化仪把节点输入计算机。根据有限元分析法的原理，将头颅定位片上的颅颌面结构份割许多三角形单元，用应变张量来描述颅颌面形态变化。     

中学生自我差异和心理健康的关系

目的 分析中学生自我差异与心理健康的关系。方法 采用自行修订的自我差异量表和SCL—90对500名中学生进行调查。结果 初中生现实自我与理想自我的差异（AI）和现实自我与应该自我的差异（AO）这两类自我差异分数都显著高于高中生。中学生两类自我差异各因子与心理健康各因子之间都显著相关（P〈0.05）。AI道德自我差异对初中生的心理健康有预测作用;AI心理自我差异与AI自我认同差异对高中生的心理健康有预测作用。结论 应针对中学生的心理特点,提高其对自我的认识,减少诱发心理问题的因素,促进中学生心理健康。     

Lung cancer and prior tuberculosis infection in Shanghai

In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, adjusted for cigarette smoking, was observed among persons who had a history of tuberculosis. Among those diagnosed with tuberculosis within the past 20 years, the risk exceeded 2.5-fold. In males the lung cancers tended to occur on the same side as the previous tuberculosis infection. For both sexes, the effect of recent tuberculosis was most apparent for adenocarcinoma and peripheral tumours. No relationship was found between lung cancer risk and the type of tuberculosis therapy, including use of isoniazid. The findings suggest that tuberculosis may predispose to lung cancer, with the association most apparent among recent survivors of the infection.     

蝮蛇抗栓酶治疗缺血性脑血管病的甲襞微循环及血液流变性观察

对使用蝮蛇抗栓酶、维脑路通的缺血性脑血管病患者各５０例进行甲襞微循环和血液流变指标的检测。结果表明：蝮蛇抗栓酶组用药后，微循环和血液流变各项异常指标显著下降（Ｐ＜０．０１～０．０５）。而维脑路通对脑血栓的微循环障碍、血液粘度、β－脂蛋白、甘油三酯、血小板聚集等异常指标改善不大（Ｐ＞０．０５）。提示：蝮蛇抗栓酶是优于维脑路通的降粘药物。     

截瘫患者血红蛋白水平的10年回顾性分析

通过对97例截瘫住院患者连续10年的Hb测定结果进行回顾性分组研究,结果表明,无并发症组10年中Hb分布较一致,其均值与正常人比较无显著性差异(P>0.05),但12.3％的病例Hb水平低于正常人下限;当截瘫并发泌尿系感染、尿毒症或难治性褥疮等病症时,则导致Hb水平的降低。提出Hb测定结果,可做为在整体水平上观察截瘫患者的治疗及康复效果的指标。     

Sympathetic skin response and R–R interval variation in chronic uremic patients

Sympathetic skin response (SSR) and R–R interval variation (RRIV) were studied in 36 chronic, nondiabetic uremics to compare with their nerve conduction studies (NCS) and clinical dysautonomia. Abnormal SSR was noted in 5 (13.9%) patients, abnormal RRIV in 14 (38.9%), and abnormal NCS in 26 (72.2%). The patients were classified into three groups: group (GP) 1: “normal,” n = 21 (58.3%), normal RRIV and SSR; GP 2: “isolated parasympathetic dysfunction,” n = 10 (27.8%), abnormal RRIV and normal SSR; and GP 3: “sympathetic sudomotor dysfunction,” n = 5 (13.9%), abnormal SSR. A significant difference in age was found among the three groups (GP 3 > GP 2 > GP 1; P < 0.0001, ANOVA). After controlling the age factor, we still noted a tendency toward increasing NCS disturbances (distal latency and nerve conduction velocity of peroneal nerve; P < 0.05, multiple regression analysis) and frequencies of clinical autonomic symptoms (postural dizziness and impotence; P < 0.05, Mantel–Hanszel test) from GP 1 to GP 3. Patients with abnormal SSR (GP 3) displayed significantly higher frequencies of postural dizziness and impotence, indicating the relationship between an absence of SSR and clinical dysautonomia. © 1994 John Wiley & Sons, Inc.     

影响原发性肝癌介入治疗生存因素的Cox模型分析

目的：了解三种介入治疗方法对原发肝癌生存因素的影响。方法：应用Ｃｏｘ回归模型对２９８例不能切除的原发性肝癌介入治疗后的预后进行多因素分析。结果：２３项指标中筛选出对生存影响显著的６项因素。按其对生存影响的大小排列分别为：肿瘤大小、二步切除、肿瘤数目、动静脉瘘、门脉癌栓和介入次数。结论：二步切除和介入次数为保护因子，能延长生存期。其余４项为危险因子，可缩短生存期。     

枸橼酸抗凝血液透析

研究解剖高危出血患者血液透析的抗凝方法－局部枸橼酸抗凝的临床应用和疗效。方法：采用１．６ｍｏｌ／Ｌ的枸橼酸钠、空心纤维透析器和普通含钙碳酸氢盐透析，观察ＲＣＡ透析对患者出血、体外循环凝血、血游离钙、总钙、Ｋ＾＋，Ｎａ＾＋，ｐＨ，ＨＣＯ＾－３，Ｓｃｒ，ＢＵＮ及血清枸橼酸浓度的影响。     

人前列腺癌细胞PC-3M亚系u-PAR基因与蛋白质表达

为研究与人前列腺癌细胞（PC-3M）侵袭能力相关的靶分子，采用有限稀释法分离单克隆细胞株，并应用单层细胞侵袭等实验鉴定各亚系的体外侵袭能力；借助RT-PCR和免疫组化的方法，分别在转录和翻译水平检测5株侵袭能力不同的PC-3M亚系尿激酶型纤溶酶原激活物受体（u-PAR)的表达。结果显示，高侵袭亚系-u-PAR基因mRNA的表达和蛋白质水平均明显高于低侵袭亚系，提示；PC-3M亚系u-PAR的高表达与其较强的侵袭能力密切相关，而u-PAR可能是抑制高侵袭亚系侵袭效应的一个重要靶分子。