全文获取类型
收费全文 | 38897篇 |
免费 | 3590篇 |
国内免费 | 2656篇 |
专业分类
耳鼻咽喉 | 200篇 |
儿科学 | 495篇 |
妇产科学 | 560篇 |
基础医学 | 4817篇 |
口腔科学 | 688篇 |
临床医学 | 4768篇 |
内科学 | 6355篇 |
皮肤病学 | 351篇 |
神经病学 | 2323篇 |
特种医学 | 1307篇 |
外国民族医学 | 23篇 |
外科学 | 4259篇 |
综合类 | 5813篇 |
现状与发展 | 12篇 |
一般理论 | 3篇 |
预防医学 | 2261篇 |
眼科学 | 972篇 |
药学 | 4027篇 |
15篇 | |
中国医学 | 1895篇 |
肿瘤学 | 3999篇 |
出版年
2024年 | 105篇 |
2023年 | 566篇 |
2022年 | 1321篇 |
2021年 | 1684篇 |
2020年 | 1375篇 |
2019年 | 1216篇 |
2018年 | 1293篇 |
2017年 | 1194篇 |
2016年 | 1134篇 |
2015年 | 1758篇 |
2014年 | 2081篇 |
2013年 | 1820篇 |
2012年 | 2902篇 |
2011年 | 3043篇 |
2010年 | 1848篇 |
2009年 | 1484篇 |
2008年 | 2088篇 |
2007年 | 2103篇 |
2006年 | 1928篇 |
2005年 | 2018篇 |
2004年 | 1381篇 |
2003年 | 1322篇 |
2002年 | 1085篇 |
2001年 | 882篇 |
2000年 | 1015篇 |
1999年 | 1076篇 |
1998年 | 641篇 |
1997年 | 690篇 |
1996年 | 511篇 |
1995年 | 483篇 |
1994年 | 438篇 |
1993年 | 299篇 |
1992年 | 314篇 |
1991年 | 325篇 |
1990年 | 288篇 |
1989年 | 251篇 |
1988年 | 217篇 |
1987年 | 211篇 |
1986年 | 181篇 |
1985年 | 136篇 |
1984年 | 100篇 |
1983年 | 78篇 |
1982年 | 32篇 |
1981年 | 43篇 |
1980年 | 28篇 |
1979年 | 32篇 |
1978年 | 25篇 |
1977年 | 19篇 |
1976年 | 18篇 |
1973年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
探讨小儿短暂性滑膜炎与病毒感染 ,特别是柯萨奇B组病毒 (CVB)感染的关系。方法 :采用酶联免疫吸附试验 (ELISA)对 16 2例小儿髋关节短暂性滑膜炎患儿静脉血和其中的 2 1例关节腔液进行病毒IgM抗体检测 ,柯萨奇病毒B组 (CVB)阳性者进行血清学分型及病毒分离。结果 :在 16 2例静脉血样本中病毒IgM阳性 6 2例 ,占总检数的 38.2 7% ,CVB -IgM2 6例占 16 .0 5 % ,AdV -IgM 19例占 11.73% ,CMV -IgM 10例占 6 .17% ,RSV -IgM 4例占 2 .4 7% ;在关节腔液中检出 9例CVB阳性 ,血清学分型 8例为CVB3,1例为CVB4 ,并分离出 1例CVB3。结论 :CVB和腺病毒 (AdV)是小儿髋关节短暂性滑膜炎感染的主要病毒 ,而且以CVB3为主。 相似文献
52.
53.
Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma 下载免费PDF全文
Serum interleukin-2 receptor (sIL-2R) level, activities of natural killer cell (NK) and lymphokine activated killer (LAK) cells were determined in 60 patients with advanced carcinoma (AC) before and after treatment with Shenmai Injection (SMI), forty healthy persons were taken as non-carcinoma control (NC). The results showed that: Serum sIL-2R level in AC were much higher than those in NC (P<0.05) and activities of NK and LAK cells in AC were much lower than those in NC (P<0.05) before treatment. There was no significant difference among gastric, colonic and lung cancer (P>0.05). After treatment with SMI, it was found that the level of sIL-2R in all patients were obviously lowered (P<0.05) while the activities of NK and LAK cells were signifficantly higher than that prior the treatment (P<0.05). Relevancy was not found between sIL-2R and NK, LAK cells. These data suggested that the immune function was compromised in AC, and SMI has a wide effect of immuno-regulation. 相似文献
54.
悬雍垂保留在悬雍垂腭咽成形术中的作用 总被引:1,自引:0,他引:1
目的 探讨悬雍垂保留在悬雍垂腭咽成形术(UPPP)中的作用。方法 比较43例UPPP与43例保留悬雍垂的改良UPPP的术中术后并发症、术后症状改善程度以及术后咽腔测量结果。结果 术中术后大出血、开放性鼻音、进流食返呛人鼻腔等并发症:改良UPPP明显低于UPPP(P<0.05);咽异物感:改良UPPP极明显低于UPPP(P<0.01)。术后1年患者主观症状改善程度:明显改善者,改良UPPP高于UPPP,无改善者,UPPP高于改良UPPP,有显著性差异(P<0.05)。术后1年咽腔扩大程度:下腭咽横径、前后径,改良UPPP较UPPP两者均明显扩大(P<0.05)。结论 UPPP中保留悬雍垂可明显降低术中术后大出血、开放性鼻音、进流食返呛人鼻腔、咽异物感等并发症,术后症状明显改善,咽腔得到明显扩大。 相似文献
55.
A study on various symptoms of chronic hepatitis treated with radix astragali and its regulative effect to levels of serum hormone 下载免费PDF全文
Ke-zhou Liu Zhong-hang Tong Ming-tai Zhang Wei-zheng Gu Zhi-rong Huang Bi-he Shen Pei-ren Cai Gui-lang Zhu Wen-nan He Lan-sheng Feng Lie-ming Ding Zhi Chen Jian-hua Jin Xiu-zhi Zhang Qian-yan Yu Shui-jin Tong Ping Ye 《中国结合医学杂志》1995,1(2):118-121
Sixty-seven cases of chronic hepatitis were treated with Radix Astragali. After treatment (2-month course), the clinical improvement rate in 38 cases of the Stagnation of the Liver-Qi and Deficiency of the Spleen type was 92.1%, and in 26 cases of the Deficiency of Liver Yin and Kidney Yin type was 88.5%, more effective than in the control group (P<0.05). The regulative effect to the levels of serum hormone was observed in the patients of the Stagnation of the Liver-Qi and Deficiency of the Spleen type treated with this medicine. The results showed that the levels of serum triiodothyronine, estradiol (female) and testosterone (male) were increased after treatment (1.40±1.38 ng/dl, 129.30±1.23 pg/ml and 496.24±1.47 ng/dl). Pre-treatment levels were 1.22±1.49 ng/dl, 104.60±1.45 pg/ml and 398. 17±1.55 ng/dl respectively (P<0.05); however, the level of serum prolactin (2.75±4.46 ng/ml) was lower after treatment than before treatment (3.20±3.82 ng/ml,P<0.05). No obvious changes were observed in the levels of serum follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, thyroxine, triiodothyronine uptake ratio and cortisol after treatment. 相似文献
56.
头孢氨苄缓释片在健康人体内的生物利用度和药物动力学 总被引:2,自引:0,他引:2
目的:比较头孢氨苄缓释片和普通胶囊的生物利用度和药物动力学。方法:10例健康志愿者分别单剂量口服500mg头孢氨苄缓释片和普通胶囊,血药浓度测定方法为HPLC法。结果:两种剂型体内过程均符合一室开放模型,缓释片的达峰时间(Tmax)为(2.58±0.59)h,峰浓度(Cmax)为(10.08±1.68)μg/ml.吸收速率常数(Ka)为(0.90±0.53)/h,消除速率常数(Ke)为(0.26±0.02)/g,半衰期(T1/2)为(2.67±0.23)h,清除率(Cl)为(6.93±1.71)L/h,分布容积(Vd)为(26.66±6.72)L,药一时曲线下面积(AUC)为(48.31±9.32)μg·h/ml。两种剂型T一C一Ka、Ke、T1/2和Cl均存在显著性差异(P<0.01),Vd、AUC无显著性差异(P>0.05);缓释片的相对生物利用度为(104.90±8.35)%。结论:缓释片的吸收减慢,Tmax推迟,T1/2延长,可减少服药次数,提高药物治疗的顺应性。 相似文献
57.
中国蒙,汉族酒依赖与醇脱氢酶和醛脱氢酶基因多态性的相关研究 总被引:7,自引:1,他引:6
为探讨醇脱氢酶(ADH)基因和醛脱氢酶(ALDH)基因多态性与酒依赖患病的相互关系,用耳血干血痕聚合酶链反应、等位基因特异性寡核苷酸探针方法,检测乙醇代谢酶ADH和ALDH基因型在我国蒙、汉民族酒依赖与非酒依赖者中分布频率。结果显示在酒依赖组(汉族52例,蒙族31例)与正常对照组(汉族48例,蒙族35例)之间:汉族的ALDH2基因型频率与等位基因频率的分布差异有非常显著性(P<0.01),而蒙族则表示为ADH2基因型频率与等位基因频率的分布差异有非常显著性(P<0.01)。这提示汉族酒依赖的发病与ALDH2基因有关,蒙族则与ADH2基因有关。 相似文献
58.
金尔伦治疗急性颅脑损伤的剂量效应研究 总被引:2,自引:1,他引:1
目的探讨金尔伦(盐酸纳洛酮)在治疗大鼠液压脑损伤后神经功能恢复和病理损害程度的剂量效应.方法将104只SD大鼠随机分为4组,伤后早期分别腹腔注射0.03 mg/Kg(小剂量组)、0.3 mg/Kg(中剂量组)、3 mg/Kg(大剂量组)金尔伦和等量生理盐水(对照组),连续7 d.结果中、大剂量组动物伤后脑神经功能恢复、脑水肿减轻程度及光、电镜检查显著优于对照组及小剂量组.结论伤后早期使用中剂量和大剂量金尔伦(盐酸纳洛酮)对大鼠液压颅脑损伤有明显的治疗效果. 相似文献
59.
60.
Dong-Hai Xiong Hui Shen Peng Xiao Yan-Fang Guo Ji-Rong Long Lan-Juan Zhao Yao-Zhong Liu Hong-Yi Deng Jin-Long Li Robert R Recker Hong-Wen Deng 《Journal of bone and mineral research》2006,21(3):424-437
A genome-wide screen was conducted using a large white sample to identify QTLs for FNCS geometry. We found significant linkage of FNCS parameters to 20q12 and Xq25, plus significant epistatic interactions and sex-specific QTLs influencing FNCS geometry variation. INTRODUCTION: Bone geometry, a highly heritable trait, is a critical component of bone strength that significantly determines osteoporotic fracture risk. Specifically, femoral neck cross-sectional (FNCS) geometry is significantly associated with hip fracture risk as well as genetic factors. However, genetic research in this respect is still in its infancy. MATERIALS AND METHODS: To identify the underlying genomic regions influencing FNCS variables, we performed a remarkably large-scale whole genome linkage scan involving 3998 individuals from 434 pedigrees for four FNCS geometry parameters, namely buckling ratio (BR), cross-sectional area (CSA), cortical thickness (CT), and section modulus (Z). The major statistical approach adopted is the variance component method implemented in SOLAR. RESULTS: Significant linkage evidence (threshold LOD = 3.72 after correction for tests of multiple phenotypes) was found in the regions of 20q12 and Xq25 for CT (LOD = 4.28 and 3.90, respectively). We also identified eight suggestive linkage signals (threshold LOD = 2.31 after correction for multiple tests) for the respective geometry traits. The above findings were supported by principal component linkage analysis. Of them, 20q12 was of particular interest because it was linked to multiple FNCS geometry traits and significantly interacted with five other genomic loci to influence CSA variation. The effects of 20q12 on FNCS geometry were present in both male and female subgroups. Subgroup analysis also revealed the presence of sex-specific quantitative trait loci (QTLs) for FNCS traits in the regions such as 2p14, 3q26, 7q21 and 15q21. CONCLUSIONS: Our findings laid a foundation for further replication and fine-mapping studies as well as for positional and functional candidate gene studies, aiming at eventually finding the causal genetic variants and hidden mechanisms concerning FNCS geometry variation and the associated hip fractures. 相似文献