全文获取类型
收费全文 | 107414篇 |
免费 | 8859篇 |
国内免费 | 6033篇 |
专业分类
耳鼻咽喉 | 967篇 |
儿科学 | 1707篇 |
妇产科学 | 966篇 |
基础医学 | 10842篇 |
口腔科学 | 1863篇 |
临床医学 | 13610篇 |
内科学 | 14036篇 |
皮肤病学 | 1622篇 |
神经病学 | 4635篇 |
特种医学 | 4124篇 |
外国民族医学 | 26篇 |
外科学 | 9335篇 |
综合类 | 21383篇 |
现状与发展 | 23篇 |
一般理论 | 7篇 |
预防医学 | 9953篇 |
眼科学 | 2362篇 |
药学 | 11602篇 |
83篇 | |
中国医学 | 6253篇 |
肿瘤学 | 6907篇 |
出版年
2024年 | 217篇 |
2023年 | 953篇 |
2022年 | 2496篇 |
2021年 | 3461篇 |
2020年 | 2719篇 |
2019年 | 2326篇 |
2018年 | 2447篇 |
2017年 | 2621篇 |
2016年 | 2692篇 |
2015年 | 4252篇 |
2014年 | 5557篇 |
2013年 | 6075篇 |
2012年 | 8847篇 |
2011年 | 9373篇 |
2010年 | 7363篇 |
2009年 | 6406篇 |
2008年 | 7414篇 |
2007年 | 7418篇 |
2006年 | 6831篇 |
2005年 | 6092篇 |
2004年 | 4806篇 |
2003年 | 4941篇 |
2002年 | 3893篇 |
2001年 | 3106篇 |
2000年 | 2414篇 |
1999年 | 1604篇 |
1998年 | 893篇 |
1997年 | 947篇 |
1996年 | 630篇 |
1995年 | 553篇 |
1994年 | 463篇 |
1993年 | 320篇 |
1992年 | 350篇 |
1991年 | 291篇 |
1990年 | 259篇 |
1989年 | 214篇 |
1988年 | 185篇 |
1987年 | 161篇 |
1986年 | 117篇 |
1985年 | 122篇 |
1984年 | 70篇 |
1983年 | 53篇 |
1982年 | 38篇 |
1981年 | 31篇 |
1980年 | 20篇 |
1979年 | 37篇 |
1978年 | 34篇 |
1976年 | 23篇 |
1973年 | 27篇 |
1970年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
根据桂枝汤的效应消除半衰期和表观消除半衰期制订给药方案的探讨 总被引:3,自引:0,他引:3
为探讨药效法估测的效应消除半衰期和效量法估测的表观半衰期对合理制订给药方案的意义和作用,以桂枝汤解热和抗炎的药物动力学实验中所得的相应参数值设计了给药方案,观察了它们在提高药效上的作用。结果表明在给药总剂量相等、首次给药同时开始的情况下,以半衰期设计的给药方案组的药效均明显高于习惯的一次给药组;而以效应消除半衰期设计给药方案组药效增强率又高于以表观半衰期设计的方案组。提示效应消除半衰期比表观半衰期似更有实践意义。 相似文献
52.
中风后癫痫的临床研究 总被引:5,自引:0,他引:5
本文报告36例中风后癫痫发作的临床和CT资料。通过回顾性病历复习和随访发现,中风后癫痫的发生率占同期住院中风患者的5.26%,以蛛网膜下腔出血和脑栓塞发生癫痫比率最高,分别为15%和12.5%。癫痫发作与CT所见病灶分布密切相关,皮质病灶较皮质下病灶更易发生病病。癫痫发作可发生于中风后任何时期,但早期癫痫以出血性中风多见,而迟发性癫痫则更多见于脑梗塞患者。 相似文献
53.
Reinaldo Figueroa MD Edilberto Martinez MD Raisa P. Fayngersh MD Hong Jiang MD Hatim A. Omar MD Nergesh Tejani MD Michael S. Wolin PhD 《American journal of obstetrics and gynecology》1995,173(6):1800-1806
OBJECTIVE: Our objective was to determine whether the observed relaxation to lactate and other agents in placental vessels of normal pregnancies is altered in severe preeclampsia.STUDY DESIGN: Isolated placental arteries and veins from women with severe preeclampsia and uncomplicated term pregnancies were precontracted with prostaglandin F2α under 5% oxygen and 5% carbon dioxide with the balance nitrogen (Po2 35 to 38 torr) and then exposed to lactate (1 to 10 mmol/L, pH 7.4, n = 8 to 15), arachidonic acid (0.01 to 10 μmol/L, n = 6 to 13), nitroglycerin (1 nmol to 1 μmol/L, n = 4 to 12), or forskolin (0.01 to 10 μmol/L, n = 6 to 9). The response to lactate was also examined in placental vessels from appropriate-for-gestational-age preterm deliveries (n = 8) for comparison with a similar group with severe preeclampsia (n = 8). The t test and analysis of variance statistics were used.RESULTS: Relaxation to lactate was markedly inhibited in both placental arteries and veins of women with severe preeclampsia compared with vessels from uncomplicated term or preterm pregnancies. Responses to the other relaxing agents were not altered in the severely preeclampsia vessels.CONCLUSIONS: In severe preeclampsia absence of lactate-induced dilatation of placental vessels may contribute to the fetal complications associated with impaired blood flow and vasospasm. 相似文献
54.
55.
缺血再灌流肾组织内皮素—1动态变化的实验研究 总被引:7,自引:1,他引:6
在大鼠肾缺血60分钟再灌注的模型上观察不同时相肾静脉血、肾皮质、外髓和内髓的内皮素1(ET1)浓度变化,肾组织ET1光镜和电镜免疫组织化学变化。结果发现:缺血再灌流肾组织ET1基因表达及分泌明显增强,主要分布在血管内皮细胞及平滑肌细胞、系膜细胞、肾小管上皮细胞。其分布特点与细胞类型和活性有关。本实验结果提示了缺血再灌注肾内ET1的变化规律。 相似文献
56.
57.
BACKGROUND: Chronic mucocutaneous candidiasis (CMC) is a rare disorder characterized by persistent or recurrent candidal infections of the skin, nails and mucous membranes or by a variable combination of endocrine failure as well as immunodeficiency. Oral clinicopathological features of CMC have seldom been described in detail. METHODS: Seven patients with CMC were reported in the study. The clinical and histological findings, etiological Candida species, immunological evaluation, and therapeutic pattern of oral lesions, were analyzed. RESULTS: Long-standing whitish hyperplastic and nodule-like lesions with exaggerated deep fissure were the typical and characteristic oral manifestations presented by all patients. The tongue was the most common site affected. Histologically, no obvious distinction was found between CMC and other forms of candidal infection. Abnormal proportions of T-lymphocyte subsets and positive titers of autoantibody were observed in three subjects (42.9%) and one patient (14.3%) respectively. Meanwhile, four subjects (57.1%) showed decreased albumin and increased globulin, three cases (42.9%) had high levels of ESR. But no iron deficiency was found. Candida albicans was the microorganism isolated from these patients. CONCLUSIONS: Multiple and widespread candidal infectious lesions can be observed on the oral cavity of CMC patients. Hyperplastic and nodule-like lesion with irremovable whitish patches and deep fissure are the most common oral manifestations of these patients. Dentists, otolaryngologists and pediatricians should be familiar with the clinical appearances of CMC to make an accurate diagnosis. Potential systemic disorders should be concerned to avoid the reoccurrence of oral candidiasis. 相似文献
58.
目的:探讨经尿道等离子前列腺双极汽化电切术(TUPKVP)治疗前列腺增生的效果。方法:回顾性分析580例良性前列腺增生(BPH)患者行TUPKVP的临床资料。结果:中转开放手术2例,切除前列腺组织10~80 g,平均32.5 g。手术时间25~150 min,平均60 min,术中输血10例,无电切综合征(TURS)发生。术后随访2~36个月,患者最大尿流率升高,IPSS症状评分值降低,排尿通畅,疗效好,并发症少。结论:TUPKVP出血少,手术安全,疗效确切,是治疗前列腺增生的有效方法。 相似文献
59.
PURPOSE: To examine the relationship between ametropia and optical aberrations in a population of 200 normal human eyes with refractive errors spanning the range from +5.00 to -10.00 D. METHODS: Using a reduced-eye model of ametropia, we tested the hypothesis that the optical system of the eye is uncorrelated with the degree of ametropia. These predictions were evaluated experimentally with a Shack-Hartmann aberrometer that measured the monochromatic aberrations across the central 6 mm of the dilated pupil in well-corrected, cyclopleged eyes. RESULTS: Optical theory predicted, and control experiments on a model eye verified, that Shack-Hartmann measurements of spherical aberration will vary with axial elongation of the eye even if the dioptric components of the eye are fixed. Contrary to these predictions, spherical aberration was not significantly different from emmetropic eyes. Root mean square of third-order aberrations, fourth-order aberrations, and total higher aberrations (third to 10th) in myopic and hyperopic eyes were also uncorrelated with refractive error. Astigmatic eyes tended to have larger total higher-order aberrations than nonastigmatic eyes. CONCLUSIONS: We conclude that a reduced-eye model of myopia assuming fixed optical parameters and variable axial length is not tenable. 相似文献
60.
Xin Hong Larry N Thibos Arthur Bradley Russell L Woods Raymond A Applegate 《Optometry and vision science》2003,80(1):15-25
Repeated measures of wavefront aberrations were taken along the line-of-sight of seven eyes using two instruments: an objective, cross-cylinder aberroscope (OA) and a Shack-Hartmann (SH) aberrometer. Both instruments were implemented on the same optical table to facilitate interleaved measurements on the same eyes under similar experimental conditions. Variability of repeated measures of individual coefficients tended to be much greater for OA data than for SH data. Although Zernike coefficients obtained from a single measurement were generally larger when measured with the OA than with the SH, the averages across five trials were often smaller for the OA. The Zernike coefficients obtained from the two instruments were not significantly correlated. Radial modulation-transfer functions and point-spread functions derived from the two sets of measurements were similar for some subjects, but not all. When average Zernike coefficients were used to determine optical quality, the OA indicated superior optics in some eyes, but the reverse trend was true if Zernike coefficients from individual trials were used. Possible reasons for discrepancies between the OA and SH measurements include difference in sampling density, quality of data images, alignment errors, and temporal fluctuations. Multivariate statistical analysis indicated that the SH aberrometer discriminated between subjects much better than did the objective aberroscope. 相似文献