全文获取类型
收费全文 | 108134篇 |
免费 | 9081篇 |
国内免费 | 5990篇 |
专业分类
耳鼻咽喉 | 975篇 |
儿科学 | 1734篇 |
妇产科学 | 978篇 |
基础医学 | 10929篇 |
口腔科学 | 1879篇 |
临床医学 | 13642篇 |
内科学 | 14121篇 |
皮肤病学 | 1629篇 |
神经病学 | 4659篇 |
特种医学 | 4163篇 |
外国民族医学 | 26篇 |
外科学 | 9419篇 |
综合类 | 21572篇 |
现状与发展 | 23篇 |
一般理论 | 7篇 |
预防医学 | 9993篇 |
眼科学 | 2362篇 |
药学 | 11686篇 |
87篇 | |
中国医学 | 6356篇 |
肿瘤学 | 6965篇 |
出版年
2024年 | 215篇 |
2023年 | 966篇 |
2022年 | 2531篇 |
2021年 | 3490篇 |
2020年 | 2765篇 |
2019年 | 2330篇 |
2018年 | 2483篇 |
2017年 | 2655篇 |
2016年 | 2712篇 |
2015年 | 4300篇 |
2014年 | 5637篇 |
2013年 | 6138篇 |
2012年 | 8923篇 |
2011年 | 9453篇 |
2010年 | 7405篇 |
2009年 | 6435篇 |
2008年 | 7452篇 |
2007年 | 7409篇 |
2006年 | 6860篇 |
2005年 | 6135篇 |
2004年 | 4825篇 |
2003年 | 4962篇 |
2002年 | 3927篇 |
2001年 | 3131篇 |
2000年 | 2444篇 |
1999年 | 1624篇 |
1998年 | 896篇 |
1997年 | 945篇 |
1996年 | 639篇 |
1995年 | 548篇 |
1994年 | 466篇 |
1993年 | 313篇 |
1992年 | 349篇 |
1991年 | 293篇 |
1990年 | 265篇 |
1989年 | 217篇 |
1988年 | 183篇 |
1987年 | 163篇 |
1986年 | 121篇 |
1985年 | 123篇 |
1984年 | 72篇 |
1983年 | 53篇 |
1982年 | 39篇 |
1981年 | 30篇 |
1980年 | 20篇 |
1979年 | 37篇 |
1978年 | 34篇 |
1976年 | 23篇 |
1973年 | 27篇 |
1970年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
941.
942.
Despite advances and improvements in diagnosis and treatment of upper aerodigestive tumors including head and neck and lung cancers, the overall survival rate of these patients remains poor. Prevention, early diagnosis, and novel therapy are under active investigation to improve the outcome of the diseases. In particular, chemopreventive strategy is a novel approach to reduce the invasive tumors by reversing the premalignant lesions with certain differentiating agents (i.e., retinoids). To conduct effective chemopreventive trials, there has been a great surge of interest in defining the biomarkers associated with the specific stages of the carcinogenesis and with intermediate end points during the therapy. Carcinogenesis in the upper aerodigestive tract has been explained by two theories, field cancerization and multistep process. The driving forces behind these processes are noted by accumulated genetic abnormalities in the entire epithelium of the airway. These genetic abnormalities include chromosome abnormalities, specific gene alterations (i.e., ras gene family, tumor suppressor genes, growth factors and their receptors), and proliferation and differentiation markers. These biomarkers are herein described in this review article. 相似文献
943.
Shin Hong Min 《Archives of pharmacal research》1980,3(2):65-74
Analysis of particle size distribution of a sample of fine aluminum hydroxide powder was carried out by four different methods,i. e., conductivity, air permeability, gas-adsorption and sedimentation. Each method was reproducible. The results obtained by Coulter counter and sedimentation balance were similar, and the data obtained by Lea and Nurse permeameter and Stroehlein areameter were also similar. But the results differ considerably between the former and the latter. The advantages and disavantages of each method were discussed briefly and a means of comparing the results with those obtained by surface area measurements was shown. 相似文献
944.
Dong M. Shin Alan M. Kramer Isaiah W. Dimery Martin N. Raber Michael Ewer Waun Ki Hong 《Investigational new drugs》1991,9(1):89-91
Summary Fourteen patients previously treated with surgery, radiotherapy, and/or chemotherapy for primary squamous cell carcinoma of the head and neck were treated with 4-O-tetrahydropyranyl-Adriamycin (THP-adriamycin) for locally or distantly recurrent disease. The starting dose was 60 mg/m2 by i.v. infusion, with courses repeated every 3 to 4 weeks. A total of 34 courses of treatment were delivered (median, 2; range, 1–6). All patients were evaluable for response and toxicity. There were no responses. Severe (grade 3 or 4) neutropenia occurred in 11 patients. Thrombocytopenia, anemia, and gastrointestinal toxicity were modest, and no hepatic, renal, or cardiac toxicity was observed. The lack of response in association with severe neutropenia and moderate other toxicities using this dose and schedule of THP-Adriamycin should be taken into consideration prior to the pursuit of further study of this compound in a similar patient population. 相似文献
945.
A novel preparative method for hexaprofen, which is a potent antiinflammatory agent, is described. Friedel-Crafts reaction of cyclohexylbenzene with ethyl α-chloro-α-(methylthio) acetate1 and α-chloro-α-(methylthio) acetonitrile2 afforded ethyl 2-(methylthio)-2-(4-cyclohexylphenyl) acetate7 and 2-methylthio-2-(4-cyclohexylphenyl) acetonitrile8, respectively. Compounds7 and8 were converted into the corresponding ethyl 2-methylthio-2-(4-cyclohexylphenyl) propionate9 and 2-methylthio-2-(4-cyclohexylphenyl) propionitrile10 by methylation with sodium hydride and methyl iodide. Hexaprofen13 was prepared by hydrolysis of ethyl 2-(4-cyclohexylphenyl) propionate11 and of 2-(4-cyclohexylphenyl) propionitrile12 followed by desulfurization of compounds9 and10. 相似文献
946.
947.
Hong M 《Hospital progress》1982,63(10):6-8, 12, 22
948.
目的 探讨高危前列腺增生症 (BPH)患者的有效手术方法。方法 采用经尿道前列腺气化术(TVP)结合电切术 (TURP)治疗高危 BPH患者 10 7例。结果 平均手术时间 5 6 m in,平均失血量 90 ml,均未输血 ,无 TURS发生。 89例术后随访 3个月至 2年 ,国际前列腺症状评分 (IPSS) ,由术前 2 6 .8± 5 .9分术后降至 8.7± 4 .3分 (P<0 .0 0 1)。最大尿流率 (Qmax)由术前 5 .0± 4 .2 ml/ s,术后升至 16 .2± 4 .5 m l/ s (P<0 .0 0 1)。剩余尿量(PUR)由术前 137.6± 5 4 .9ml术后降至 2 1.8± 16 .1ml(P<0 .0 0 1)。结论 TVP结合 TURP安全性高、并发症少、效果确切 ,只要处理方法得当 ,适合高危 BPH患者 相似文献
949.
不同浓度依达拉酮注射液的细菌内毒素检测方法 总被引:3,自引:0,他引:3
目的:建立依达拉酮注射液的细菌内毒素检查方法。方法:用凝胶法比较不同浓度的依达拉酮注射液对细菌内毒素检测的干扰情况。结果:采用灵敏度为0.125EU·mL~(-1)的鲎试剂,将本品稀释后,浓度小于或等于0.0375g·L~(-1)时对鲎试剂与内毒素的凝集反应无干扰。结论:本品可用细菌内毒素检查法代替热原检查来控制其质量,其细菌内毒素限期值可定为3.33EU·mg~(-1)。 相似文献
950.
目的 探索氩氮靶向冷冻治疗系统(氩氮刀)在脑胶质瘤治疗中的应用价值。方法 开颅后,根据MRI及CT设计冷冻范围,应用氩氮刀冷冻-复温-冷冻后切除胶质瘤,并取冷冻前后标本送病理检查。结果 8例Ⅱ~Ⅳ级胶质瘤患者肿瘤均达到全切,术中出血少,术后短期未见副作用及神经功能缺失。冷冻前后病理切片对比:与冷冻前对比,冷冻后标本在普通显微镜下见有明显出血灶;透射电镜下可见几乎所有细胞核膜肿胀,核形状不规则,染色质凝结为粗颗粒状,明显边聚,线粒体明显肿胀,部分破裂崩解。结论氩氮靶向冷冻治疗系统治疗脑胶质瘤具有能直接摧毁肿胀细胞、手术安全、出血少、全切率高的优点。 相似文献