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41.
Central nervous system involvement following diagnosis of non-Hodgkin's lymphoma: a risk model. 总被引:5,自引:4,他引:5
BACKGROUND: To determine the incidence and risk factors for central nervous system (CNS) relapse in patients with non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS: Patient records were registered prospectively in successive patients with NHL admitted to the Norwegian Radium Hospital from 1980 to 1996. A total of 2514 patients had no CNS involvement at diagnosis and were treated according to standard protocols. The incidence and risk factors for CNS progression or relapse were examined retrospectively. RESULTS: In low-grade (L)-NHL, the risk of CNS involvement was low (2.8%). In high-grade (H)-NHL, lymphoblastic and Burkitt's NHL patients had a high risk of CNS recurrence (24.4%) at 5 years, and prophylaxis seemed to reduce this risk. For the other patients with H-NHL, the proportion with CNS involvement at 5 years was 5.2%. Multivariate analysis identified five independent risk factors, each present in >5% of patients: elevated serum lactate dehydrogenase, serum albumin <35 g/l, <60 years of age, retroperitoneal lymph node involvement and involvement of more than one extranodal site. If four or five of these risk factors were present, the risk of CNS recurrence was in excess of 25% at 5 years. CONCLUSIONS: The risk of CNS involvement in this study is comparable with the results from other large series. CNS prophylaxis is not recommended in any subgroup of L-NHL. The risk of CNS involvement among patients with either Burkitt's or lymphoblastic lymphomas is considerable and these patients should therefore receive intensive chemotherapy including systemic and intrathecal methotrexate. Patients with other types of H-NHL should receive adequate CNS prophylaxis if at least four of the five risk factors identified are present. 相似文献
42.
Janjaap van der Net Patrick van der Torre Raoul HH Engelbert Vivian Engelen Femke van Zon Tim Takken Paul JM Helders 《Pediatric rheumatology online journal》2008,6(1):2
Objective
To describe the level of motor performance and functional skills in young children with JIA. 相似文献43.
Sofie H. Slrdahl Erlend B. Smeland Harald Holte Morten Grnn Sverre O. Lie Martin Seip 《Pediatric blood & cancer》1993,21(4):254-258
Among 16 patients with Down's syndrome (DS) and acute leukemia admitted to our department during a ten year period, 6 were diagnosed as acute megakaryoblastic leukemia (AMkL). The diagnosis was based on clinical and hematologic criteria, confirmed in three patients with the use of monoclonal antibodies (MoAb) specific for megakaryocytic antigens. In these three, and in a fourth patient, the leukemic blasts were positive for other myeloid, lymphoid and erythroid markers in MoAb testing. We suggest that AMkL in DS is a mixed lineage leukemia with blasts presenting a variety of cell surface antigens, indicating origin from an early progenitor cell with the capability of megakaryocytic differentiation. Of the 6 patients with AMkL, 4 treated with standard AML protocols are in complete continuing remission (CCR) with observation periods from 57+ to 148+ months. © 1993 Wiley-Liss, Inc. 相似文献
44.
Summary This paper reviews the principles, developments and concepts embodied in the experience gained over 10 years with simultaneous combined anterior and posterior fusion (SCAPF) of the spine in over 750 patients. The procedure was initially designed for the surgical treatment of failed post-discectomy syndromes. Indications have expanded due to increasing experience and the rapid, predictable fusion which accompanies this technique. The current technique allows for a solid anterior fusion combined with extensive posterior decompression and removal of the primary anatomical pain sources involved with low back pain and disability. 相似文献
45.
Angibaud P Arts J Van Emelen K Poncelet V Pilatte I Roux B Van Brandt S Verdonck M De Winter H Ten Holte P Marien A Floren W Janssens B Van Dun J Aerts A Van Gompel J Gaurrand S Queguiner L Argoullon JM Van Hijfte L Freyne E Janicot M 《European journal of medicinal chemistry》2005,40(6):597-606
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency. 相似文献
46.
Asle?HoffartEmail author Harold?Sexton Liv?M.?Hedley Catharina?E.?Wang Harald?Holthe Jon?A.?Haugum Hans?M.?Nordahl Ole?Johan?Hovland Arne?Holte 《Cognitive therapy and research》2005,29(6):627-644
One thousand and thirty-seven psychiatric patients and non-patients from six different sites completed the 205-item Young
Schema Questionnaire or its shortended form, the 75-item Young Schema Questionnaire-S. Among 888 of the subjects, who all
were patients, a confirmatory factor analysis (CFA) of the 75 items included in both forms of the questionnaire clearly yielded
the 15 Early Maladaptive Schema (EMS) factors rationally developed by J. E. Young (1990). Confirmatory factor analyses, testing
three models of the higher-order structure of the 15 EMSs, indicated that a four-factor model was the best alternative. The
results slightly favored a correlated four second-order factor model over one also including a third-order global factor.
The four factors or schema domains were Disconnection, Impaired Autonomy, Exaggerated Standards, and Impaired Limits. Scales
derived from the four higher-order factors had good internal and test–retest reliabilities and were related to DSM-IV Cluster
C personality traits, agoraphobic avoidance behavior, and depressive symptoms. 相似文献
47.
48.
Liberal versus restrictive fluid administration to improve recovery after laparoscopic cholecystectomy: a randomized, double-blind study 总被引:9,自引:0,他引:9
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Holte K Klarskov B Christensen DS Lund C Nielsen KG Bie P Kehlet H 《Annals of surgery》2004,240(5):892-899
OBJECTIVE: The objective of this study was to investigate the effects of 2 levels of intraoperative fluid administration on perioperative physiology and outcome after laparoscopic cholecystectomy. SUMMARY BACKGROUND DATA: Intraoperative fluid administration is variable as a result of limited knowledge of physiological and clinical effects of different fluid substitution regimens. METHODS: In a double-blind study, 48 ASA I-II patients undergoing laparoscopic cholecystectomy were randomized to 15 mL/kg (group 1) or 40 mL/kg (group 2) intraoperative administration of lactated Ringer's solution (LR). All other aspects of perioperative management as well as preoperative fluid status were standardized. Primary outcome parameters were assessed repeatedly for the first 24 postoperative hours and included pulmonary function (spirometry), exercise capacity (submaximal treadmill test), cardiovascular hormonal responses, balance function, pain, nausea and vomiting, recovery, and hospital stay. RESULTS: Intraoperative administration of 40 mL/kg compared with 15 mL/kg LR led to significant improvements in postoperative pulmonary function and exercise capacity and a reduced stress response (aldosterone, antidiuretic hormone, and angiotensin II). Nausea, general well-being, thirst, dizziness, drowsiness, fatigue, and balance function were also significantly improved, as well as significantly more patients fulfilled discharge criteria and were discharged on the day of surgery with the high-volume fluid substitution. CONCLUSIONS: Intraoperative administration of 40 mL/kg compared with 15 mL/kg LR improves postoperative organ functions and recovery and shortens hospital stay after laparoscopic cholecystectomy. 相似文献
49.
50.
Holte L 《Pediatric annals》2003,32(7):461-465
The explosion of information regarding the genetics of hearing loss, the extraordinary effectiveness of early intervention, and the widespread practice of universal newborn hearing screening make for exciting times for those who serve young children who are deaf or hard-of-hearing and their families. These rapid changes in the knowledge base and practice standards also require the cooperation and help of pediatricians to enable children to take full advantage of available opportunities to optimize development of early communication. 相似文献