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91.
BACKGROUND: Deterioration of renal function and rise in blood pressure are
clinically important side-effects of cyclosporin (CsA) treatment. Calcium
antagonists may have a renoprotective effect against CsA nephrotoxicity.
PURPOSE: To investigate the effect of the dihydropyridine calcium-channel
blocker felodipine on renal haemodynamics, tubular sodium handling, and
blood pressure in CsA- treated patients with no primary renal disease, 18
patients with various CsA-treated dermatological diseases were allocated to
receive either felodipine 5 mg (extended release tablets) once daily for 4
weeks followed by placebo for 4 weeks, or vice versa, in a prospective,
randomized, double-blind study. The patients were investigated before
treatment and at the end of each treatment period. RESULTS: After
felodipine, both glomerular filtration rate (GFR) and renal plasma flow
(RPF) were significantly higher compared to placebo (89.4 +/- 17.5 (mean
+/- SD) vs 79.0 +/- 15.9 ml/min and 412.0 +/- 107.6 vs 326.1 +/- 78.0
ml/min respectively, P < 0.001 for both), and filtration fraction (FF)
was lower (0.22 +/- 0.03 vs 0.25 +/- 0.03, P < 0.001). Both systolic and
diastolic blood pressure were lower after felodipine compared to placebo
(116 +/- 11/71 +/- 7 vs 133 +/- 18/83 +/- 10 mmHg, P < 0.001 for both).
Furthermore, proximal output of sodium, i.e. fractional excretion of
lithium, was higher after felodipine (26.9 +/- 7.3% vs 20.4 +/- 5.5%, P
< 0.001) as well as total sodium excretion (0.33 +/- 0.19 vs 0.19 +/-
0.08 mmol/min, P < 0.001). CONCLUSIONS: It is concluded, that felodipine
5 mg once daily for 4 weeks increased GFR, RPF, and sodium excretion in
cyclosporin-treated dermatological patients with no primary renal disease.
Furthermore, felodipine lowers blood pressure in these patients. The
effects of felodipine may be due to an antagonizing effect against
CsA-induced nephrotoxicity.
相似文献
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Heart-lung transplantation: the postoperative chest radiograph 总被引:2,自引:0,他引:2
Chiles C; Guthaner DF; Jamieson SW; Stinson EB; Oyer PE; Silverman JF 《Radiology》1985,154(2):299-304
The postoperative chest radiographs of 10 patients who had undergone heart-lung transplantation at Stanford University Medical Center were evaluated and compared with those of 10 consecutive cardiac transplantation patients and 10 consecutive coronary artery bypass graft patients. In the second week after surgery, we observed an interstitial radiographic pattern in the heart-lung transplantation patients but not in the other two patient populations. This pattern, which did not correspond with any clinical evidence of infection, rejection, fluid overload, or oxygen toxicity, may represent the reimplantation response described in dogs and primates following transplantation of a single lung. This response may be related to the interruption of bronchial circulation, the denervation of both lungs, and the lymphatic interruption that occur during transplantation. It may also be related to the obligatory period of ischemia that is incurred during implantation. 相似文献
95.
By conventional criteria, perfusion defects that correspond to radiographic parenchymal opacities of similar size have less diagnostic significance for pulmonary embolism (PE) than perfusion defects in areas that are radiographically clear, regardless of the findings on ventilation scan. It was proposed that the demonstration of normal ventilation in areas with matched radiographic opacity and perfusion defects does support the diagnosis of PE. To test this hypothesis, a retrospective review was done of selected cases from a consecutive series of 85 pulmonary angiography studies. Cases were reviewed if the following criteria were met: chest radiography, ventilation-perfusion scintigraphy, and angiography of the relevant regions had all been performed within 24 hours of one another, and there was a radiographic opacity corresponding to the perfusion defect. Sixteen cases fulfilled these criteria. Six patients had normal ventilation in the regions of the radiographic infiltrate and perfusion defect, and all had PE. No patient had an area of opacity and perfusion defect and normal ventilation without PE. 相似文献
96.
Anette Raa Christine Stansberg Vidar M Steen Rolf Bjerkvig Rolf K Reed Linda EB Stuhr 《BMC cancer》2007,7(1):23
Background
This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. 相似文献97.
Estrogen-induced microsatellite DNA alterations are associated with Syrian hamster kidney tumorigenesis 总被引:4,自引:0,他引:4
Exposure to estrogens is associated with an increase in cancers, including
malignancies of the breast and uterus in humans, and of the kidney in
hamsters. DNA damage induced by metabolic activation of estrogen has been
postulated to result in gene mutations critical for the development of
estrogen-induced kidney tumors in hamsters. As part of our examination of
the genetic consequences of estrogen-induced DNA damage, we searched for
estrogen-induced alterations in microsatellite DNA, a frequent site of
mutation in tumors. Genomic DNA isolated from kidney of hamsters treated
with estradiol, from estrogen-induced kidney tumors and from untreated
age-matched controls, was examined by Southern blot analysis with three
multi-locus oligonucleotide probes: (GACA)4, (CAC)6 and (CAG)6. Alterations
in DNA fragments containing GACA and CAC tandem repeats were detected in
kidney DNA of hamsters treated with hormone for 3 and 4 months, whereas no
such effects were seen in control animals. In estrogen-induced tumors,
microsatellite alterations were observed in fragments that contain these
same two repeat sequences and also CAG repeat sequences. The induction of
microsatellite alterations by estradiol in kidney DNA preceding
estrogen-induced renal malignancy may play a role in hormone-induced
tumorigenesis.
相似文献
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Z Gholami I Mobedi HR Esmaeili EB Kia 《Asian Pacific Journal of Tropical Biomedicine》2011,1(3):189-192