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951.
Yuko Higashi Munekazu Yamakuchi Tomoko Fukushige Atsuko Ibusuki Teruto Hashiguchi Takuro Kanekura 《Experimental dermatology》2018,27(2):178-184
Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index (BMI) is a risk factor for psoriasis; inflammasomes are activated by adipose tissue macrophages in obese subjects. We hypothesized that hyperlipidaemia is involved in the pathogenesis of psoriasis and examined the role of a high‐fat diet (HFD) in the development of psoriasis in imiquimod (IMQ)‐treated mice. The body weight and serum level of cholesterol were significantly higher in mice fed an HFD than in a regular diet (RD). HFD mice had higher psoriasis skin scores, and the number of neutrophils infiltrating into the lesional skin was elevated. IL‐17A mRNA expression was significantly increased in the skin of IMQ‐treated HFD mice; the expression of IL‐22, IL‐23 and TNF‐α mRNA was not enhanced. Caspase‐1 and IL‐1β were activated in the skin of IMQ‐treated HFD mice, and their serum level of IL‐17A, TNF‐α and IL‐1β was significantly upregulated. Our findings strongly suggest that hyperlipidaemia is involved in the development and progression of psoriasis via systemic inflammation and inflammasome activation. 相似文献
952.
Incremental value of left atrial active function measured by speckle tracking echocardiography in patients with hypertrophic cardiomyopathy 下载免费PDF全文
Kaori Fujimoto MD Katsuji Inoue MD Makoto Saito MD Haruhiko Higashi MD Tamami Kono MD Teruyoshi Uetani MD Jun Aono MD Takayuki Nagai MD Kazuhisa Nishimura MD Jun Suzuki MD Takafumi Okura MD Shuntaro Ikeda MD Satoshi Nakatani MD Jitsuo Higaki MD 《Echocardiography (Mount Kisco, N.Y.)》2018,35(8):1138-1148
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Hepatobiliary and Pancreatic: Degenerative hepatic hemangioma mimicking biliary cystadenocarcinoma 下载免费PDF全文
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Contribution of Contrast‐Enhanced Sonography With Perfluorobutane Microbubbles for Diagnosis of Recurrent Hepatocellular Carcinoma 下载免费PDF全文
Buyanjargal Shagdarsuren MD Hideyuki Tamai MD PhD Naoki Shingaki MD Yoshiyuki Mori MD Shuya Maeshima MD Junya Nuta MD Yoshimasa Maeda MD Kosaku Moribata MD PhD Toru Niwa MD PhD Hisanobu Deguchi MD Izumi Inoue MD PhD Takao Maekita MD PhD Mikitaka Iguchi MD PhD Jun Kato MD PhD Masao Ichinose MD PhD 《Journal of ultrasound in medicine》2016,35(7):1383-1391
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Kota Arima Hirohisa Okabe Daisuke Hashimoto Akira Chikamoto Akira Tsuji Kensuke Yamamura Yuki Kitano Risa Inoue Takayoshi Kaida Takaaki Higashi Katsunobu Taki Katsunori Imai Yoshihiro Komohara Toru Beppu Motohiro Takeya Hideo Baba 《International journal of clinical oncology / Japan Society of Clinical Oncology》2016,21(5):940-945
959.
Teiji Ukawa Tsuneo Takayanagi Haruka Morimoto Yukihito Higashi Naomi Idei Masao Yoshizumi Toshio Tsuji 《Medical & biological engineering & computing》2012,50(12):1239-1247
Measurement of flow-mediated dilatation (FMD) is the conventional non-invasive method for assessment of endothelial function; however, it requires an expensive ultrasound system and high levels of technical skill. Therefore, we developed a novel method for measurement of endothelial function, namely, measurement of ezFMD. ezFMD estimates the degree of vasodilatation from the oscillation signals transmitted to a sphygmomanometer cuff attached to the upper arm. The objective of this study was to validate the principle underlying the measurement of ezFMD, and to evaluate the repeatability of the ezFMD measurements. We observed the blood vessel behavior and oscillometric pattern in ten subjects. When the cuff was inflated to the level of the mean blood pressure, the oscillation amplitude increased with increasing degree of vasodilatation. In experiment to evaluate the repeatability of the ezFMD measurement, the average difference between the paired measurements was 3.7?%, the standard deviation was 11.5?%, and the average coefficient of variation value for the 11 paired measurements was 23.7?%. These results suggest the validity of the principle underlying the measurement of the ezFMD for the assessment of endothelial function. And, this study suggests that the repeatability of the ezFMD measurements is superior to that of the conventional measurement of FMD. 相似文献
960.
Prognostic Significance of Hepatic Vein Waveform by Doppler Ultrasonography in Cirrhotic Patients with Portal Hypertension 总被引:7,自引:0,他引:7
Masayuki Ohta M.D. Makuto Hashizume M.D. Hirofumi Kawanaka M.D. Kouhei Akazawa Ph.D. Morimasa Tomikawa M.D. Hidefumi Higashi M.D. Fumiaki Kishihara M.D. Kazuo Tanoue M.D. Keizo Sugimachi M.D. 《The American journal of gastroenterology》1995,90(10):1853-1857
Objective: We prospectively evaluated the prognostic value of the flat hepatic vein waveform, measured by Doppler ultrasound, in cirrhotic patients with portal hypertension.
Methods: The Doppler pattern of right and left hepatic veins in a series of 120 consecutive cirrhotic patients with portal hypertension but without hepatocellular carcinoma was examined, together with clinical and biochemical parameters.
Results: Flat waveform of the right hepatic vein was recognized in nine patients and that of the left hepatic vein was seen in 13. After a mean follow-up of 13.6 ± 9.7 months, 17 patients died, all from liver failure. In the univariate analysis, variables significantly associated with the duration of survival were age, etiology of the liver cirrhosis, upper gastrointestinal bleeding after start of the study, Child-Pugh score, ascites, encephalopathy, prothrombin index, bilirubin, albumin, and flat Doppler waveform in the right and left hepatic veins. Multivariate analysis showed that flat Doppler waveform in the right hepatic vein, bilirubin, and prothrombin index were independently related to survival.
Conclusions: The prognostic accuracy in cases of cirrhosis with portal hypertension is significantly improved with acquistion of information obtained from hepatic vein waveform by Doppler ultrasound. 相似文献
Methods: The Doppler pattern of right and left hepatic veins in a series of 120 consecutive cirrhotic patients with portal hypertension but without hepatocellular carcinoma was examined, together with clinical and biochemical parameters.
Results: Flat waveform of the right hepatic vein was recognized in nine patients and that of the left hepatic vein was seen in 13. After a mean follow-up of 13.6 ± 9.7 months, 17 patients died, all from liver failure. In the univariate analysis, variables significantly associated with the duration of survival were age, etiology of the liver cirrhosis, upper gastrointestinal bleeding after start of the study, Child-Pugh score, ascites, encephalopathy, prothrombin index, bilirubin, albumin, and flat Doppler waveform in the right and left hepatic veins. Multivariate analysis showed that flat Doppler waveform in the right hepatic vein, bilirubin, and prothrombin index were independently related to survival.
Conclusions: The prognostic accuracy in cases of cirrhosis with portal hypertension is significantly improved with acquistion of information obtained from hepatic vein waveform by Doppler ultrasound. 相似文献