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151.
Hiroyuki Baba 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1982,218(6):283-286
The aqueous humor proteins of exfoliation syndrome were studied qualitatively by crossed immunoelectrophoresis and compared with normal controls. Two kinds of macromolecules (1-lipoprotein and ceruloplasmin) were detected more frequently in exfoliation syndrome than in the normal controls. 1Lp was detected in eight of ten patients with exfoliation syndrome, but in none of the eight controls. Cp was detected in seven of ten patients with exfoliation syndrome, but in only one of the eight controls.The presence of these macromolecules in the anterior chamber suggests high permeability of vessels in the exfoliation syndrome. This interpretation is also supported by the fact that neovascularization is sometimes present in the iris of the exfoliation syndrome.In the aqueous humor from a patient with diabetic retinopathy, ten kinds of aqueous humor proteins were identified. 相似文献
152.
Gastric Acidity following Pancreaticogastrostomy with Pylorus-preserving Pancreaticoduodenectomy 总被引:4,自引:0,他引:4
Pancreaticogastrostomy (PG) has been reintroduced and employed occasionally as a useful alternative to pancreaticojejunostomy
(PJ) after Whipple resection or pylorus-preserving pancreaticoduodenectomy (PPPD). Although the physiologic alteration in
the stomach is important for the correlation between gastric and pancreatic functions, the actual intragastric pH profile
after PG is still unclear. This study was conducted to investigate the physiologic changes in gastric pH and serum gastrin
and secretin levels before and after PPPD reconstructed with PG (PPPD-PG) in humans. Twenty-four hour continuous intragastric
pH and serum gastrin and secretin levels in the fasting state were examined in 25 patients who had undergone PPPD-PG. No peptic
ulcer was detected after the operation. After PG, serum gastrin and secretin levels were unchanged. Twenty-four hour gastric
pH monitoring revealed two distinct patterns during the nocturnal period before the operation: patients with acid-type secretion
(n= 11) exhibited a persistent acid pH, whereas those with alkaline-type secretion (n= 14) had cyclic variations between an acid and an alkaline pH value. After PG, in both acid- and alkaline-type patients,
median pH and percentages of time that the gastric pH was less than 4 (% pH < 4) and more than 6 (% pH > 6) did not change,
and circadian pH patterns also remained unchanged. These results suggest that PPPD-PG has little influence on gastric acidity,
and the neurohumoral relation between the stomach, duodenum, and pancreas is preserved after PG. Therefore, physiologically,
PG can be recommended as a reconstructive procedure after PPPD. 相似文献
153.
154.
155.
Motoki Abe MD Satoshi Kondo Satoshi Hirano Yoshiyasu Ambo Eiichi Tanaka Toshiaki Morikawa Shunichi Okushiba Hiroyuki Katoh 《Journal of gastrointestinal cancer》2003,33(2-3):107-110
A 65-yr-old man who underwent pancreaticoduodenectomy with portal vein resection for pancreatic cancer is alive 8 yr after surgery. Originally, computed tomography (CT) revealed an 8-cm tumor in the pancreatic head. The tumor had infiltrated the portal vein, but grew expansively, so there was neither biliary obstruction nor jaundice. Pancreaticoduodenectomy with resection of the portal vein was performed for pancreatic cancer. Many tumor-infiltrating lymphocytes were seen within cancer cell nests on routine histopathology. We performed immunostaining for CD8, and found that a large number of the lymphocytes were CD8+ T cells. The patient’s prognosis was considered poor because the tumor was large and had infiltrated the portal vein. We suspect that long-term survival may be related to the response of CD8+ T cells to the cancer. 相似文献
156.
Increased plasma ghrelin level in lung cancer cachexia. 总被引:14,自引:0,他引:14
Yoshito Shimizu Noritoshi Nagaya Takeshi Isobe Michinori Imazu Hiroyuki Okumura Hiroshi Hosoda Masayasu Kojima Kenji Kangawa Nobuoki Kohno 《Clinical cancer research》2003,9(2):774-778
PURPOSE: Ghrelin, a novel growth hormone-releasing peptide,has been shown to cause a positive energy balance by stimulating food intake and inducing adiposity. We sought to investigate the pathophysiology of ghrelin in cachexia associated with lung cancer. EXPERIMENTAL DESIGN: Plasma ghrelin level was measured in 43 patients with lung cancer and 21 control subjects. Patients with lung cancer were divided into two groups: patients with cachexia (n = 21) and those without cachexia (n = 22). RESULTS: Plasma ghrelin level did not significantly differ between all patients with lung cancer and controls (157 +/- 10 versus 132 +/- 8 fmol/ml, P = 0.1). However, plasma ghrelin level was significantly higher in patients with cachexia than in those without cachexia (180 +/- 17 versus 135 +/- 10 fmol/ml, P = 0.011). Furthermore, plasma ghrelin level increased significantly in patients with decreased food intake after chemotherapy (from 136 +/- 11 fmol/ml to 170 +/- 16 fmol/ml on day 8, 179 +/- 20 fmol/ml on day 21 after start of chemotherapy), although plasma ghrelin level did not significantly change in those without decreased food intake. CONCLUSIONS: Baseline plasma ghrelin level was elevated in cachectic patients with lung cancer, and follow-up plasma ghrelin level increased in patients with anorexia after chemotherapy. Considering the positive energy effects induced by ghrelin, increased ghrelin may represent a compensatory mechanism under catabolic-anabolic imbalance in cachectic patients with lung cancer. 相似文献
157.
Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. 总被引:5,自引:0,他引:5
158.
Associations of alcohol, height, and reproductive factors with serum hormone concentrations in postmenopausal Japanese women 总被引:5,自引:0,他引:5
Chisato Nagata Michinori Kabuto Naoyoshi Takatsuka Hiroyuki Shimizu 《Breast cancer research and treatment》1997,44(3):235-241
We measured serum levels of estradiol (E2), sex hormone-binding globulin (SHBG), progesterone, and dehydroepiandrosterone sulfate (DHEAS) in 61 postmenopausal women drawn from female residents in a community in Japan to evaluate the relationships between these hormone levels and potential breast cancer risk factors. The information on reproductive history, body size, alcohol use, and physical activity was obtained by means of a self-administered questionnaire. There was a significant trend in increasing E2 level with increasing height after taking account of age and body mass index (BMI) (p for trend = 0.04). BMI was inversely associated with SHBG level after controlling for age (p for trend = 0.01). Decreasing progesterone with increasing BMI was observed after controlling age and history of hysterectomy (P=0.05). Alcohol consumption was positively associated with E2 level and there was a strong linear trend after controlling for age, height, and BMI (p for trend=0.001). Trend for increasing DHEAS with alcohol consumption was also statistically significant after controlling for age and history of hysterectomy (p for trend=0.01). Reproductive factors as well as physical activity were not related to any of the hormone levels. 相似文献
159.
Hiroyuki Suzuki Shichisaburo Abo Michihiko Kitamura Masaji Hashimoto Keiichi Izumi Kunihiko Terada Toshihiro Sugiyama 《Cancer investigation》1997,15(5):411-415
Gene amplification is a relatively frequent event in human malignant tumors and is believed to play an important role in tumor progression. The int-2 and erbB genes are amplified more frequently than any other genes in human esophageal cancer. In order to investigate the correlation between these two proto-oncogenes and the clinical behavior of esophageal cancer, we examined DNA amplification of int-2 and erbB and analyzed their relationship to clinicopathological variables. Genomic DNA was extracted from 21 esophageal squamous carcinomas and normal esopfiageal mucosa, as well as from 4 metastatic tumors. We used Southern blot analysis for detection of gene amplification. Amplification of int-2 was observed in 13 of 21 cases (62%) and in all the metastatic tumors (4/4; 100%). We found a significant correlation between amplification of int-2 and the length of the primary lesion. Amplification of erbB was detected in 3 of 18 patients (17%). All patients who showed amplification of erbB also demonstrated amplification of int-2. These results suggest that amplification of int-2 or neighboring genes on 11q may participate in tumor progression and metastasis in patients with esophageal squamous cancer. 相似文献
160.