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The Role of Leukapheresis in the Current Management of Hyperleukocytosis in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia 下载免费PDF全文
Rosa Nguyen MD Sima Jeha MD Yinmei Zhou MS Xueyuan Cao PhD Cheng Cheng PhD Deepa Bhojwani MD Patrick Campbell MD PhD Scott C. Howard MD Jeffrey Rubnitz MD PhD Raul C. Ribeiro MD John T. Sandlund MD Tanja Gruber MD PhD Hiroto Inaba MD PhD Ching‐Hon Pui MD Monika L. Metzger MD MS 《Pediatric blood & cancer》2016,63(9):1546-1551
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Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease 总被引:1,自引:0,他引:1
Recent pharmacotherapy trials in Parkinson's disease (PD) using dopaminergic neuroimaging as outcome parameter failed to show significant relationships between imaging and clinical results. One possible explanation is that there is a non-linear relationship between striatal denervation and motor performance reflecting a statistical "floor" effect in the imaging data with advanced disease. Both the motor manifestations and the striatal dopamine denervation of idiopathic PD, however, are typically asymmetric and more meaningful associations may be found by comparing data from the least denervated striatum with motor performance in the corresponding body side. PD patients (n=28) underwent [11C]beta-CFT dopamine transporter (DAT) positron emission tomography (PET) and grooved pegboard testing. Voxel-based analysis of DAT PET and bimanual pegboard scores demonstrated significant correlation clusters within the bilateral striata (P<0.001). However, findings were most prominent in the least denervated striatum. There was a significant inverse correlation between pegboard scores of the least affected arm and DAT binding of the least denervated striatum (Rs=-0.69, P<0.0001) but no significant correlation between pegboard scores of the clinically most affected arm and DAT binding of the most denervated striatum (Rs=-0.15, ns). These data indicate that the robustness of the grooved pegboard test as a biomarker for nigrostriatal denervation in PD mainly reflects the relationship between test performance of the clinically least affected limb and the least denervated striatum. These findings indicate that there is both a statistical "floor" and "ceiling" effect for the most affected striatal and body sides that must be considered when employing imaging as an outcome measure in clinical trials in PD. 相似文献
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Kimura Yuta Tsunedomi Ryouichi Yoshimura Kiyoshi Matsukuma Satoshi Shindo Yoshitaro Matsui Hiroto Tokumitsu Yukio Yoshida Shin Iida Michihisa Suzuki Nobuaki Takeda Shigeru Ioka Tatsuya Hazama Shoichi Nagano Hiroaki 《Annals of surgical oncology》2022,29(12):7423-7433
Annals of Surgical Oncology - Poor prognosis in liver cancer is due to its high frequency of intrahepatic metastasis. Cancer stem-like cells (CSLCs), which possess the properties of stemness, tumor... 相似文献
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Yamashita Takehiro Terasaki Hiroto Tanaka Minoru Nakao Kumiko Sakamoto Taiji 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(8):1779-1785
Graefe's Archive for Clinical and Experimental Ophthalmology - To determine the relationship between the peripapillary choroidal thickness (ppCT) and the degree and distribution of the... 相似文献
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Deepali Kumar Oriol Manuel Yoichiro Natori Hiroto Egawa Paolo Grossi Sang‐Hoon Han Mario Fernndez‐Ruiz Atul Humar 《American journal of transplantation》2020,20(7):1773-1779
The COVID‐19 pandemic has rapidly evolved and changed our way of life in an unprecedented manner. The emergence of COVID‐19 has impacted transplantation worldwide. The impact has not been just restricted to issues pertaining to donors or recipients, but also health‐care resource utilization as the intensity of cases in certain jurisdictions exceeds available capacity. Here we provide a personal viewpoint representing different jurisdictions from around the world in order to outline the impact of the current COVID‐19 pandemic on organ transplantation. Based on our collective experience, we discuss mitigation strategies such as donor screening, resource planning, and a staged approach to transplant volume considerations as local resource issues demand. We also discuss issues related to transplant‐related research during the pandemic, the role of transplant infectious diseases, and the influence of transplant societies for education and disseminating current information. 相似文献
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Yojiro Koda Hiroto Kitahara Sara Kalantari Bow Chung Bryan Smith Jayant Raikhelkar Gene Kim Nitasha Sarswat Gabriel Sayer David Onsager Tae Song Nir Uriel Valluvan Jeevanandam Takeyoshi Ota 《Artificial organs》2020,44(4):367-374
The purpose of this study is to compare clinical outcomes of left ventricular assist device (LVAD) patients with device thrombosis who underwent device exchange (DE) or medical therapy (MT) alone. Consecutive patients undergoing LVAD implant between July 2008 and December 2017 were included. Device thrombosis was diagnosed with comprehensive assessments including ramp test, laboratory data, device parameters, and clinical presentations. First, MT was initiated in all patients. After MT, DE was considered if device thrombosis was refractory to initial MT, and it caused end-organ impairment and/or hemodynamic instability. Among 319 consecutive LVAD patients, 43 patients (13.5%) were diagnosed with device thrombosis. DE was performed in 28 patients (DE group); device explant was performed in 1 patient. MT was continued in 14 patients (MT group). In-hospital mortality was significantly lower in the DE group than the MT group (3.6% [1/28] vs. 28.6% [4/14], P = .0184). One-year survival was significantly better in the DE group (74.0% vs. 30.1%; log-rank = .001), and freedom from cerebrovascular accident (CVA) at 1 year was greater in the DE group (87.1% vs. 47.7%; log-rank = .004). DE was associated with improved 1-year survival and fewer CVAs. Surgical intervention, if feasible, is recommended for LVAD device thrombosis. 相似文献
109.
Noma Saki Yamashita Takehiro Asaoka Ryo Terasaki Hiroto Yoshihara Naoya Kakiuchi Naoko Sakamoto Taiji 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(12):2781-2789
Graefe's Archive for Clinical and Experimental Ophthalmology - Recently, artificial intelligence has been used to determine sex using fundus photographs alone. We had earlier reported that sex... 相似文献
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