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91.
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Satoshi Taniwaki Makoto Kataoka Hironori Tanaka Yoshiki Mizuno Masao Hirose 《Journal of gastroenterology》1997,32(4):548-552
68-year-old woman presented with abdominal pain and vomiting. After initial conservative therapy, laparotomy showed multiple
ulcers of the ileum, one of which had perforated and adhered to the uterus. The affected segment of the ileum was resected.
Numerous cytomegalic cells, corresponding to endothelia and macrophages, with intranuclear inclusion bodies, were found in
microscopic sections of the ulcerated lesions. These findings were consistent with cytomegalic vasculitis and enteritis.Cytomegalovirus infections of the alimentary tract have been, reported mainly in severely immunocompromised patients or those with predisposing
disorders such as ulcerative colitis; their prognosis is usually poor. In our patient, there was no obvious immunocompromised
state or other gastrointestinal disorders. The postoperative course has been uneventful for 2 years after surgery. The prognosis
ofCytomegalovirus-associated lesions in the alimentary tract may be quite good in the immunocompetent patient. 相似文献
93.
Aging and DNA methylation 总被引:1,自引:0,他引:1
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Takagi T Matsuda M Abe M Kobayashi H Fukuhara A Komuro R Kihara S Caslake MJ McMahon A Shepherd J Funahashi T Shimomura I 《Atherosclerosis》2008,196(1):114-121
In the West of Scotland Coronary Prevention Study (WOSCOPS), treatment of hypercholesterolemic men with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, reduced their likelihood to progress to diabetes mellitus by 30%. However, the mechanism of this effect of pravastatin has not been investigated. In the current study, we examined the effect of pravastatin on the development of diabetes in obese diabetic mice, and on the insulin-induced glucose uptake and adiponectin production. Pravastatin treatment attenuated the development of diabetes in db/db and high fat/high sucrose diet-fed C57BL/6J mice. An in vivo glucose transport assay showed that pravastatin upregulated glucose uptake in adipose tissue. Insulin-stimulated glucose uptake was enhanced in primary adipocytes isolated from pravastatin-treated mice. Pravastatin treatment increased adiponectin production in 3T3-L1 adipocytes. Plasma adiponectin levels were significantly increased in pravastatin-treated mice. Analyses of plasma samples from the WOSCOPS biobank indicated a significant increase of plasma adiponectin levels with pravastatin treatment (placebo -0.28+/-0.34 microg/ml versus pravastatin +1.47+/-0.33 microg/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment. 相似文献
96.
Mitsuyoshi Takahara Iichiro Shimomura 《Reviews in endocrine & metabolic disorders》2014,15(4):317-327
A clustering of metabolic abnormalities such as dyslipidemia, hypertension, and diabetes mellitus, all of which are major risk factors for cardiovascular disease (CVD), occurs more often than by chance. Numerous epidemiological studies, as well as basic researches, have revealed that visceral fat accumulation is closely involved in this risk clustering. This morbid condition is now well recognized as the metabolic syndrome. The concept of the metabolic syndrome, i.e., the involvement of visceral adiposity in the clustering of CVD risk factors, implies that an effective CVD risk reduction will be accomplished by an intervention to reduce visceral fat deposits. The primary strategy of the intervention is lifestyle modification, which can be put into practice in healthcare fields, without necessity of medical treatment. Now that CVD is a leading global health burden, the metabolic syndrome attracts increasing attention in the world. To take global action against the syndrome, several working groups developed its internationally unified diagnostic criteria. Most recently, the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) jointly proposed the criteria, although some cautions will be needed in their practical use. In this review, we mainly focus on the findings observed in clinical and epidemiological studies, to discuss a practical strategy of the management of the metabolic syndrome in healthcare fields. 相似文献
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Hiroshi Morimoto Hironori Shimada Kenichi Ozaki 《International journal of behavioral medicine》2014,21(3):447-455