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181.
182.
Masahito Sawahata Daisuke Mori Yuko Arioka Hisako Kubo Itaru Kushima Kanako Kitagawa Akira Sobue Emiko Shishido Mariko Sekiguchi Akiko Kodama Ryosuke Ikeda Branko Aleksic Hiroki Kimura Kanako Ishizuka Taku Nagai Kozo Kaibuchi Toshitaka Nabeshima Kiyofumi Yamada Norio Ozaki 《Psychiatry and clinical neurosciences》2020,74(5):318-327
183.
184.
Higuchi Takashi Sugisawa Norihiko Yamamoto Jun Oshiro Hiromichi Han Qinghong Yamamoto Norio Hayashi Katsuhiro Kimura Hiroaki Miwa Shinji Igarashi Kentaro Tan Yuying Kuchipudi Shreya Bouvet Michael Singh Shree Ram Tsuchiya Hiroyuki Hoffman Robert M. 《Cancer chemotherapy and pharmacology》2020,85(2):285-291
Cancer Chemotherapy and Pharmacology - Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the efficacy of... 相似文献
185.
Naohiro Sekiguchi Shinya Rai Wataru Munakata Kenshi Suzuki Hiroshi Handa Hirohiko Shibayama Tomoyuki Endo Yasuhito Terui Noriko Iwaki Noriko Fukuhara Hiro Tatetsu Shinsuke Iida Takayuki Ishikawa Ryota Shiibashi Koji Izutsu 《Cancer science》2020,111(9):3327-3337
Tirabrutinib is a second‐generation Bruton’s tyrosine kinase inhibitor with greater selectivity than ibrutinib. Here, we conducted a multicenter, phase II study of tirabrutinib in patients with treatment‐naïve (Cohort A) or with relapsed/refractory (Cohort B) Waldenström’s macroglobulinemia (WM). Patients were treated with tirabrutinib 480 mg once daily. The primary endpoint was major response rate (MRR; ≥ partial response). Secondary endpoints included overall response rate (ORR; ≥ minor response), time to major response (TTMR), progression‐free survival (PFS), overall survival (OS), and safety. In total, 27 patients (18 in Cohort A; 9 in Cohort B) were enrolled. The median age was 71 y, and the median serum immunoglobulin M level was 3600 mg/dL. Among the patients, 96.2% had the MYD88L265P mutation. MRR and ORR were 88.9% and 96.3%, respectively (Cohort A: MRR, 88.9%; ORR, 94.4%; Cohort B: MRR, 88.9%; ORR, 100%). Median TTMR was 1.87 mo. PFS and OS were not reached with a median follow‐up of 6.5 and 8.3 mo for Cohorts A and B, respectively. The most common adverse events (AEs) were rash (44.4%), neutropenia (25.9%), and leukopenia (22.2%), with most AEs classified as grade 1 or 2. Grade ≥ 3 AEs included neutropenia (11.1%), lymphopenia (11.1%), and leukopenia (7.4%). No grade 5 AEs were noted. All bleeding events were grade 1; none were associated with drug‐related atrial fibrillation or hypertension. Although the follow‐up duration was relatively short, the study met the primary endpoint. Therefore, tirabrutinib monotherapy is considered to be highly effective for both untreated and relapsed/refractory WM with a manageable safety profile. (JapicCTI‐173646). 相似文献
186.
Kentaro Jujo Hiromichi Hamada Atsushi Iwakura Tina Thorne Haruki Sekiguchi Trevor Clarke Aiko Ito Sol Misener Toshikazu Tanaka Ekaterina Klyachko Koichi Kobayashi J?rn Tongers Jér?me Roncalli Yukio Tsurumi Nobuhisa Hagiwara Douglas W. Losordo 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(24):11008-11013
We hypothesized that a small molecule CXCR4 antagonist, AMD3100 (AMD), could augment the mobilization of bone marrow (BM)-derived endothelial progenitor cells (EPCs), thereby enhancing neovascularization and functional recovery after myocardial infarction. Single-dose AMD injection administered after the onset of myocardial infarction increased circulating EPC counts and myocardial vascularity, reduced fibrosis, and improved cardiac function and survival. In mice transplanted with traceable BM cells, AMD increased BM-derived cell incorporation in the ischemic border zone. In contrast, continuous infusion of AMD, although increasing EPCs in the circulation, worsened outcome by blocking EPC incorporation. In addition to its effects as a CXCR4 antagonist, AMD also up-regulated VEGF and matrix metalloproteinase 9 (MMP-9) expression, and the benefits of AMD were not observed in the absence of MMP-9 expression in the BM. These findings suggest that AMD3100 preserves cardiac function after myocardial infarction by enhancing BM-EPC–mediated neovascularization, and that these benefits require MMP-9 expression in the BM, but not in the ischemic region. Our results indicate that AMD3100 could be a potentially useful therapy for the treatment of myocardial infarction. 相似文献
187.
Hiroaki Yokomori Fumihiko Kaneko Aya Sato Hajime Takeuchi Kumiko Tahara Tadashi Motoori Yasunobu Sekiguchi Shigehisa Mori Jun‐ichi Tamaru Toshifumi Hibi 《Hepatology research》2008,38(10):1054-1057
Hodgkin's lymphoma (HL) is in general a lymph node‐based disease. Hepatic involvement usually occurs in the advanced disease. Primary and prominent manifestation of the disease in the liver is extremely rare. We report magnetic resonance imaging leading to diagnosis in a rare case of liver involvement as the first sign of HL. 相似文献
188.
Ogawa T Kim GH Sekiguchi H Akai M Suzuki S Nakazawa K 《European journal of applied physiology》2009,105(2):199-205
The purpose of this study was to investigate effects of long-term participation to swimming on adaptations of spinal reflex
excitability. To this end, mechanically induced stretch reflex (SR) and electrically induced Hoffmann (H-) reflex of the soleus
muscle were investigated between swimmers with experience of more than 10 years and non-trained individuals while sitting
at rest. The amplitude and the gain (stretch velocity vs. amplitude of the reflex response) of the SR were significantly greater
in the swimming group than in the non-trained control group. Similarly, the responses of the H-reflex were also significantly
greater in the swimming group than in the non-trained control group. Results of this study demonstrated that the spinal reflex
excitability in experienced swimmers was far more enhanced than in non-trained individuals. 相似文献
189.
Harumi Hotta Kazuto Masamoto Sae Uchida Yuta Sekiguchi Hiroyuki Takuwa Hiroshi Kawaguchi Kazuhiro Shigemoto Ryo Sudo Kazuo Tanishita Hiroshi Ito Iwao Kanno 《Journal of cerebral blood flow and metabolism》2013,33(9):1440-1447
To clarify mechanisms through which activation of the nucleus basalis of Meynert (NBM) increases cerebral cortical blood flow, we examined whether cortical parenchymal arteries dilate during NBM stimulation in anesthetized mice. We used two-photon microscopy to measure the diameter of single penetrating arteries at different depths (∼800 μm, layers I to V) of the frontal cortex, and examined changes in the diameter during focal electrical stimulation of the NBM (0.5 ms at 30 to 50 μA and 50 Hz) and hypercapnia (3% CO2 inhalation). Stimulation of the NBM caused diameter of penetrating arteries to increase by 9% to 13% of the prestimulus diameter throughout the different layers of the cortex, except at the cortical surface and upper part of layer V, where the diameter of penetrating arteries increased only slightly during NBM stimulation. Hypercapnia caused obvious dilation of the penetrating arteries in all cortical layers, including the surface arteries. The diameters began to increase within 1 second after the onset of NBM stimulation in the upper cortical layers, and later in lower layers. Our results indicate that activation of the NBM dilates cortical penetrating arteries in a layer-specific manner in magnitude and latency, presumably related to the density of cholinergic nerve terminals from the NBM. 相似文献
190.
Purpose The aim of this study was to assess the variation of probe rotation angles for detecting a single needle using sagittal images
of transrectal ultrasonography (TRUS).
Materials and methods A phantom study was performed. One needle was inserted through each of 10 holes of the template, and variations in the probe
rotation angles for detecting the needle were measured.
Results The mean variation of probe rotation for detecting a single needle was 17.0° (range 4°–25°). Slightly broader variation was
seen for the needle in holes farther away from the probe.
Conclusion Probe rotation angles for detecting a single needle displayed considerable variation. Seed locations recognized on sagittal
imaging by TRUS are thus indeterminate, and real-time dose calculations using TRUS for 125I seed implantation should be used with care. 相似文献