全文获取类型
收费全文 | 10024篇 |
免费 | 533篇 |
国内免费 | 93篇 |
专业分类
耳鼻咽喉 | 113篇 |
儿科学 | 209篇 |
妇产科学 | 89篇 |
基础医学 | 1141篇 |
口腔科学 | 175篇 |
临床医学 | 745篇 |
内科学 | 3061篇 |
皮肤病学 | 73篇 |
神经病学 | 628篇 |
特种医学 | 509篇 |
外科学 | 1690篇 |
综合类 | 45篇 |
预防医学 | 270篇 |
眼科学 | 101篇 |
药学 | 444篇 |
中国医学 | 8篇 |
肿瘤学 | 1349篇 |
出版年
2023年 | 154篇 |
2022年 | 284篇 |
2021年 | 454篇 |
2020年 | 224篇 |
2019年 | 281篇 |
2018年 | 370篇 |
2017年 | 253篇 |
2016年 | 273篇 |
2015年 | 254篇 |
2014年 | 368篇 |
2013年 | 398篇 |
2012年 | 690篇 |
2011年 | 720篇 |
2010年 | 415篇 |
2009年 | 327篇 |
2008年 | 567篇 |
2007年 | 545篇 |
2006年 | 531篇 |
2005年 | 510篇 |
2004年 | 489篇 |
2003年 | 483篇 |
2002年 | 441篇 |
2001年 | 136篇 |
2000年 | 123篇 |
1999年 | 138篇 |
1998年 | 123篇 |
1997年 | 99篇 |
1996年 | 92篇 |
1995年 | 58篇 |
1994年 | 60篇 |
1993年 | 52篇 |
1992年 | 80篇 |
1991年 | 87篇 |
1990年 | 67篇 |
1989年 | 47篇 |
1988年 | 43篇 |
1987年 | 51篇 |
1986年 | 32篇 |
1985年 | 34篇 |
1984年 | 33篇 |
1983年 | 20篇 |
1982年 | 14篇 |
1981年 | 22篇 |
1980年 | 16篇 |
1979年 | 23篇 |
1978年 | 18篇 |
1977年 | 13篇 |
1974年 | 13篇 |
1973年 | 18篇 |
1968年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
141.
The high frequency of fall accidents is a serious problem in Japan. Thus, more
stringent countermeasures for preventing falls from scaffolds were developed and
incorporated into institutional guidelines. These countermeasures aim to decrease deaths
caused by falls from scaffolds. Despite the improvements in such measures, however, the
rate of accidental fall deaths remains high in Japan’s construction industries. To improve
the rigor of the countermeasures, a committee was established in our institute by the
Japan Ministry of Health, Labour, and Welfare. This committee investigated the regulations
applied in other countries and evaluated construction industry compliance with existing
fall prevention guidelines. After considerable research and discussion, the Occupational
Safety and Health Regulations and Guidelines were amended in 2009. The effects of the
amended regulations have recently been investigated on the basis of accident reports. This
paper describes the investigation and its results. The paper also discusses other research
and workplace safety countermeasures for preventing falls and ensuring fall protection
from heights. 相似文献
142.
143.
Sayed Ahmad Zikri Bin Sayed Aluwee Xiangrong Zhou Hiroki Kato Hiroshi Makino Chisako Muramatsu Takeshi Hara Masayuki Matsuo Hiroshi Fujita 《Radiological physics and technology》2017,10(3):279-285
We propose an approach to supporting pre-surgical planning for the uterus by integrating medical image analysis and physical model generation based on 3D printing. With our method, we first segment the patient-specific anatomy and lesions of the uterus on MR images; then, we create a 3D physical model, an exact replica of the patient’s uterus in terms of size and softness, with transparency for easy observation of the internal structures of the uterus. In our experiments, we created pre-surgical models of hysterectomy for five patients who had been diagnosed to have uterine endometrial cancer. An experienced radiologist, the surgeons, and all of the patients cooperated in our experiment for carrying out subjective evaluations of the usefulness of our model. The accuracy of the physical models was evaluated quantitatively by comparison between the MR images of the patients and the CT images of the models. The results showed that the mean values of the errors in gap ranged from 1.19 to 2.22 mm, which was satisfactory for the surgeons. The feedback from both surgeons and patients demonstrated the usefulness and convenience of the models for efficient patient explanation understanding and pre-surgical planning by surgeons. 相似文献
144.
Masanori Hashimoto Shinichi Fujita Kazuhiko Endo Hiroki Ohno 《European journal of oral sciences》2009,117(5):611-617
The purpose of this study was to evaluate the durability of one-bottle self-etching adhesive during long-term water-storage testing. Resin–dentin bonded specimens were prepared using four commercially available one-bottle self-etching adhesives. The specimens were sectioned perpendicular to the adhesive interface to produce beam-shaped specimens that were stored in water for 24 h (control group) and 100, 200, and 300 d (experimental groups). After each storage period, the beams were subjected to a microtensile bond test. After the bond test, fractured surfaces were examined using a scanning electron microscope. In addition, interfacial observations of the silver tracer were performed using the secondary and back-scatter modes of the scanning electron microscope. The bond strength of all tested adhesives decreased significantly after 100 or more days in water. The interfacial observations showed an oxygen-inhibition zone as electron lucent in the adhesive–composite border in control specimens, displaying silver impregnation with breakage after aging. The deterioration of the oxygen-inhibition zone in the adhesive–resin composite junction resulted in a decrease in bond strength after 100 d in water for one-bottle self-etching adhesives. 相似文献
145.
Fumiki?Yoshihara Miki?Imazu Toshimitsu?Hamasaki Toshihisa?Anzai Satoshi?Yasuda Shin?Ito Haruko?Yamamoto Kazuhiko?Hashimura Yoshio?Yasumura Kiyoshi?Mori Masataka?Watanabe Masanori?Asakura Masafumi?Kitakaze 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2018,32(2):183-190
Background and Aims
Sodium-dependent glucose transporter-2 (SGLT-2) inhibitors, which are anti-diabetic drugs, reportedly decrease the incidence of cardiovascular events in high-risk patients with cardiovascular diseases, and thus chronic heart failure (CHF). SGLT-2 inhibitors also decrease albuminuria in patients with type 2 diabetes mellitus (T2D). Since albuminuria is a biomarker of not only chronic kidney disease but also cardiovascular events, we hypothesized that, among T2D patients with CHF, SGLT-2 inhibitors will decrease the extent of albuminuria and also improve CHF concomitantly.Methods
DAPPER (UMIN000025102) is a multicenter, randomized, open-labeled, parallel-group, standard treatment-controlled study, which is designed to evaluate whether dapagliflozin, one of the SGLT-2 inhibitors, decreases albuminuria in T2D patients with CHF and exerts cardioprotective effects on the failing heart. The patients are randomized to either of the dapagliflozin (5 or 10 mg, once daily orally) or control group (administration of anti-diabetic drugs administered other than SGLT 2 inhibitors). The estimated number of patients that need to be enrolled is 446 in total (223 in each group). The primary objective is the changes in the urinary albumin-to-creatinine ratio from the baseline after 2-year treatment. The key secondary objectives are (1) the safety of dapagliflozin and (2) the cardiovascular and renal efficacies of dapagliflozin.Conclusion and Perspectives
DAPPER study investigates whether dapagliflozin decreases albuminuria and exerts beneficial effects on the failing heart in T2D patients. (UMIN000025102).146.
Koichiro Takahashi Hironori Sadamatsu Kumiko Suzuki Hiroki Tashiro Shinya Kimura Yuichiro Kuratomi Naoko Sueoka-Aragane 《Respiratory investigation》2021,59(1):126-134
BackgroundEosinophilic chronic rhinosinusitis (ECRS) is often complicated by asthma and can be difficult to diagnose. This study aimed to clarify the usefulness of the self-administered odor questionnaire (SAOQ) and visual analog scale (VAS) to identify olfactory disorders in patients with asthma.MethodsThis retrospective study was conducted on patients with asthma who were referred to the Otolaryngology clinic between May and September 2018. The treatment step of asthma, asthma control test (ACT), pulmonary function test, peripheral blood eosinophils, and fractional exhaled nitric oxide (FeNO) were analyzed. ECRS was diagnosed based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study score. Olfactory dysfunction was evaluated using the SAOQ and VAS for olfactory disorders.ResultsThe study included 56 patients (18 males and 38 females), who were divided into two groups; those with ECRS (n = 18) and those without ECRS (n = 38). Age, sex, treatment step, ACT score, and pulmonary function were not significantly different between the groups. The ECRS group had a significantly higher FeNO value (89.1 ppb vs. 39.1 ppb) and a significantly lower SAOQ score (40.1% vs. 96.1%). The area under the receiver operating characteristic curve for the efficacy of ECRS diagnosis was 0.88, 0.889, 0.799, and 0.757 for SAOQ, VAS, blood eosinophil count, and FeNO, respectively.ConclusionThe SAOQ and VAS scores were useful tools that presented similar results to the blood eosinophil count and FeNO, and may help to improve the diagnosis of ECRS in patients with asthma. 相似文献
147.
Vitamin K2 induces differentiation of leukemic cell lines and apoptosis of immature blasts in myelodysplastic syndrome (MDS). We recently reported a case of MDS-refractory anemia (MDS-RA) with trilineage hematologic response to oral administration of menatetrenone, a vitamin K2 analog. To determine a possible role of this agent in treatment of MDS-RA, we conducted a prospective randomized trial assessing the safety and efficacy of menatetrenone. A total of 18 consecutive patients newly diagnosed with MDS-RA were randomized to receive either 45 mg of oral menatetrenone (group 1) or no menatetrenone (group 2). Administration of menatetrenone was well tolerated. Of the nine patients in group 1 (56%), five improved with menatetrenone treatment while only one (11%) of the group 2 patients improved. Three patients (33%) showed a major response in absolute neutrophil count (ANC), two (22%) showed a major response in hemoglobin concentration, and two of the nine (22%) showed a major response in platelet count. The ANC of group 1 patients rose after treatment, while that of group 2 patients decreased slightly at follow-up after 16 weeks ( p=0.03). Significant improvement was also seen in final platelet count ( p=0.01), but not in hemoglobin concentration. Given the absence of toxicity, menatetrenone can be recommended for all patients with MDS-RA. 相似文献
148.
Baba A Yoshikawa T Chino M Murayama A Mitani K Nakagawa S Fujii I Shimada M Akaishi M Iwanaga S Asakura Y Fukuda K Mitamura H Ogawa S;Keio Interhospital Cardiology Study 《Japanese circulation journal》2001,65(10):867-873
Few previous reports have comprehensively screened all the anti-myocardial autoantibodies (AMCA) in relation to other clinical profiles in patients with idiopathic dilated cardiomyopathy (IDC), so the present study used both immunohistochemistry (FITC) and immunoblotting (IB) for screening patients with IDC in order to characterize the clinical significance of AMCA. Sera were collected from 100 patients with IDC and age-matched 100 healthy control subjects (CTL). For FITC, an unfixed frozen section of human myocardium was used for the standard indirect immunofluorescence; for IB, total cardiac homogenates of the same myocardium were blotted to serum at 2 sets of dilution (1:200 and 1:10,000). The positive rates of AMCA detection for each method were as follows (IDC vs CTL); 39% vs 6% for FITC, 38% vs 4% for IB (1:200), and 10% vs 0% for IB (1:10,000). Fifty-nine patients with IDC and 8 CTL were positive for AMCA by either method, and 18 patients with IDC and 2 CTL were positive for AMCA by both methods. IB-positivity at 1:200 was an independent predictor by multiple logistic regression analysis of non-sustained ventricular tachycardias as well as left ventricular end-diastolic diameter and plasma norepinephrine concentration. 相似文献
149.
Miyashita N Fukano H Hara H Yoshida K Niki Y Matsushima T 《Internal medicine (Tokyo, Japan)》2002,41(1):30-33
Two cases of recurrent pneumonia due to Chlamydia pneumoniae are described. C. pneumoniae was continuously detected from the nasopharynx in both patients by the polymerase chain reaction and/or culture even with appropriate antibiotic therapy during the first episode. After eradication of C. pneumoniae with long-term macrolide therapy, the respiratory symptoms of both patients completely disappeared and no relapse was observed. These data indicate that new treatment strategies may be necessary to eradicate the organism in patients prone to persistent infection. 相似文献
150.
Takahashi H Takeishi Y Seidler T Arimoto T Akiyama H Hozumi Y Koyama Y Shishido T Tsunoda Y Niizeki T Nozaki N Abe J Hasenfuss G Goto K Kubota I 《Circulation》2005,111(12):1510-1516