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排序方式: 共有1767条查询结果,搜索用时 15 毫秒
11.
Atsuo Murata Hitoshi Toda Ken -Ichi Uda Hirohito Hayashida Takeshi Kato Hidewaki Nakagawa Shigekazu Yokoyama Hideaki Morishita Toru Yamakawa Jiro Hirose Takesada Mori Nariaki Matsuura 《Inflammation》1994,18(4):337-347
Severe inflammatory responses after major surgeries, trauma, and infection develop multiple organ dysfunction. In the mechanisms of the pathogenesis of these responses, activated neutrophils are thought to be important in terms of their ability to produce various kinds of proteinases, which can degrade various proteins constructing human tissues. Among their proteinases, neutrophil elastase is the strongest serine proteinase secreted from activated neutrophils. Thus, we examined in this study the inhibitory effect and therapeutic efficacy of newly produced recombinant human Kunitz-type proteinase inhibitor (R-020), which coded the second domain of human urinary trypsin inhibitor. R-020 was effective in significantly improving the survival rate after induction of the rat lethal peritonitis model (cecal ligation and punctureinduced septic shock model). We suggest that various serine proteinases are implicated in the pathogenesis of neutrophil-related multiple organ failure and that recombinant human Kunitz-type proteinase inhibitor might be effective in the treatment of these kinds of organ dysfunction. 相似文献
12.
Hidai C Kawana M Habu K Kazama H Kawase Y Iwata T Suzuki H Quertermous T Kokubun S 《The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology》2005,287(2):1165-1175
In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery. 相似文献
13.
Katsutoshi Kawasaki Shigeru Miyazaki Eishin Yaoita Takashi Kazama Tadashi Yamamoto Itaru Kihara 《Pathology international》1986,36(3):429-437
A clearance kinetic study of intravenously administered 125 I-labeled aggregated human IgG (125 I-AHIgG) from the circulation and its distribution in various organs was performed weekly during the course in a model of experimental immune complex glomerulonephritis which was induced in rats immunized 8 weeks previously with 6 times a week administration of 2 mg of bovine serum albumin (BSA) for 4 weeks from week 8 to 12. The removal rates of the injected 125 I-AHIgG from the circulation were retarded in nonproteinuric rats of week 9 and 10, at almost every checked point (p-value was <0.01). The clearance in those rats with severe proteinuria returned to the level of the control and of rats in week 8. The distribution of 125 I-AHIgG in the liver 4 hours after the administration revealed a considerable decrease in non-overt proteinuric rats of weeks 9, 10, and 11. A similar tendency of decreasing depositions of the radioactivity was shown in the spleen at each 4 hours. In contrast, the uptakes in the kidney and lung at the final week of 12 were larger. Delayed clearance from the circulation and a decreasing handle of the injected macromolecule in the liver and possibly in the spleen may suggest the presence of some impairment of the MPS function in the course of this experimental glomerulonephritis. 相似文献
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Ishihara Hiroki Fukuda Hironori Tachibana Hidekazu Yoshida Kazuhiko Kobayashi Hirohito Takagi Toshio Iizuka Junpei Ishida Hideki Nagashima Yoji Kondo Tsunenori Tanabe Kazunari 《Clinical and experimental nephrology》2021,25(6):674-682
Clinical and Experimental Nephrology - The data regarding oncological outcome in advanced renal cell carcinoma (RCC) arising in end-stage renal disease (ESRD) are limited. Patients diagnosed with... 相似文献
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17.
Hirohito Yano Takashi Funakoshi Jun Shinoda Noboru Sakai George Kokuzawa Kuniyasu Shimokawa 《Brain tumor pathology》1997,14(1):75-78
A 35-year-old woman had an intradural tumor in the posterior fossa adjacent to the posterior wall of the left pyramidal bone,
which was totally removed and histologically diagnosed as a pleomorphic adenoma. Follow-up examination for 2 years showed
no recurrence of the tumor. There was no primary lesion in any other gland of the body, and therefore there is no alternative
but to conclude a “migration” of some gland cells. The pathogenesis of this tumor remains unclassified. 相似文献
18.
Toshiaki Watanabe Takamitsu Kanazawa Yoshihiro Kazama Junichiro Tanaka Toshiaki Tanaka Soichiro Ishihara Hirokazu Nagawa 《Journal of clinical oncology》2005,23(35):9031-2; author reply 9032-3
19.
Results of a 36‐year surveillance program for ulcerative colitis‐associated neoplasia in the Japanese population
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Junko Kishikawa Keisuke Hata Shinsuke Kazama Hiroyuki Anzai Takahide Shinagawa Koji Murono Manabu Kaneko Kazuhito Sasaki Koji Yasuda Kensuke Otani Takeshi Nishikawa Toshiaki Tanaka Tomomichi Kiyomatsu Kazushige Kawai Hiroaki Nozawa Soichiro Ishihara Teppei Morikawa Masashi Fukayama Toshiaki Watanabe 《Digestive endoscopy》2018,30(2):236-244
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