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771.
Peigne V Chaize M Falissard B Kentish-Barnes N Rusinova K Megarbane B Bele N Cariou A Fieux F Garrouste-Orgeas M Georges H Jourdain M Kouatchet A Lautrette A Legriel S Regnier B Renault A Thirion M Timsit JF Toledano D Chevret S Pochard F Schlemmer B Azoulay E 《Critical care medicine》2011,39(6):1365-1371
772.
Bacteriophages carrying antibiotic resistance genes in fecal waste from cattle, pigs, and poultry 总被引:1,自引:0,他引:1
Colomer-Lluch M Imamovic L Jofre J Muniesa M 《Antimicrobial agents and chemotherapy》2011,55(10):4908-4911
This study evaluates the occurrence of bacteriophages carrying antibiotic resistance genes in animal environments. bla(TEM), bla(CTX-M) (clusters 1 and 9), and mecA were quantified by quantitative PCR in 71 phage DNA samples from pigs, poultry, and cattle fecal wastes. Densities of 3 to 4 log(10) gene copies (GC) of bla(TEM), 2 to 3 log(10) GC of bla(CTX-M), and 1 to 3 log(10) GC of mecA per milliliter or gram of sample were detected, suggesting that bacteriophages can be environmental vectors for the horizontal transfer of antibiotic resistance genes. 相似文献
773.
The serotonin transporter is an important regulator of serotonergic signaling. In order to analyze where the Drosophila melanogaster ortholog of the mammalian serotonin transporter (dSERT) is expressed in the nervous system, a dSERT antibody serum was used. Ectopic expression studies and loss of function analysis revealed that the dSERT antibody serum specifically recognizes dSERT. It was shown that in the embryonic nervous system dSERT is expressed in a subset of Engrailed-positive neurons. In the larval brain, dSERT is exclusively expressed in serotonergic neurons, all of which express dSERT. dSERT-positive neurons surround almost all brain neuropiles. In the mushroom body of the adult brain, extrinsic serotonergic neurons expressing dSERT engulf the mushroom body lobes. These neurons show regional differences in dSERT and serotonin expression. At the presynaptic terminals, serotonin release is sterically linked to serotonin reuptake. In contrast to this, there are other areas in serotonergic neurons where dSERT expression and/or function are uncoupled from synaptic neurotransmitter recycling and serotonin release. The localization pattern of dSERT can be employed to further understanding and analysis of serotonergic networks. 相似文献
774.
Ramos R Baena-Díez JM Quesada M Solanas P Subirana I Sala J Alzamora M Forès R Masiá R Elosua R Grau M Cordón F Pera G Rigo F Martí R Ponjoan A Cerezo C Brugada R Marrugat J 《Atherosclerosis》2011,214(2):474-479
BackgroundThe recommendation of screening with ankle brachial index (ABI) in asymptomatic individuals is controversial. The aims of the present study were to develop and validate a pre-screening test to select candidates for ABI measurement in the Spanish population 50–79 years old, and to compare its predictive capacity to current Inter-Society Consensus (ISC) screening criteria.Methods and resultsTwo population-based cross-sectional studies were used to develop (n = 4046) and validate (n = 3285) a regression model to predict ABI < 0.9. The validation dataset was also used to compare the model's predictive capacity to that of ISC screening criteria.The best model to predict ABI < 0.9 included age, sex, smoking, pulse pressure and diabetes. Assessment of discrimination and calibration in the validation dataset demonstrated a good fit (AUC: 0.76 [95% CI 0.73–0.79] and Hosmer–Lemeshow test: χ2: 10.73 (df = 6), p-value = 0.097).Predictions (probability cut-off value of 4.1) presented better specificity and positive likelihood ratio than the ABI screening criteria of the ISC guidelines, and similar sensitivity. This resulted in fewer patients screened per diagnosis of ABI < 0.9 (10.6 vs. 8.75) and a lower proportion of the population aged 50–79 years candidate to ABI screening (63.3% vs. 55.0%).ConclusionThis model provides accurate ABI < 0.9 risk estimates for ages 50–79, with a better predictive capacity than that of ISC criteria. Its use could reduce possible harms and unnecessary work-ups of ABI screening as a risk stratification strategy in primary prevention of peripheral vascular disease. 相似文献
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Gastelurrutia P Lupón J Domingo M Ribas N Noguero M Martinez C Cortes M Bayes-Genis A 《The American journal of cardiology》2011,(8):1166-1170
The obesity paradox in heart failure (HF) is criticized because of the limitations of body mass index (BMI) in correctly characterizing overweight and obese patients, necessitating a better evaluation of nutritional status. The aim of this study was to assess nutritional status, BMI, and significance in terms of HF survival. Anthropometry and biochemical nutritional markers were assessed in 55 HF patients. Undernourishment was defined as the presence of ≥2 of the following indexes below the normal range: triceps skinfold, subscapular skinfold, arm muscle circumference, albumin, and total lymphocyte count. Patients were also stratified by BMI and followed for a median of 26.7 months. Across BMI strata, no patient was underweight, 31% were normal weight, 42% were overweight, and 27% were obese. Undernourishment was present in 53% of normal-weight patients, 22% of overweight patients, and none of the obese patients (p = 0.001). Undernourished patients had significantly higher mortality (p = 0.009) compared to well-nourished patients. In multivariate analysis, only undernutrition (hazard ratio 3.149, 95% confidence interval 1.367 to 7.253), New York Heart Association functional class (hazard ratio 3.374, 95% confidence interval 1.486 to 7.659), and age (hazard ratio 1.115, 95% confidence interval 1.045 to 1.189) remained in the model. Among nutritional indicators, subscapular skinfold was the best predictor of mortality; patients with subscapular skinfold in the fifth percentile had higher mortality (p = 0.0001). In conclusion, BMI does not indicate true nutritional status in HF. Classifying patients as well nourished or undernourished may improve risk stratification. 相似文献
779.
780.
A novel locus for non-syndromic sensorineural deafness (DFN6) maps to chromosome Xp22 总被引:4,自引:0,他引:4
del Castillo I; Villamar M; Sarduy M; Romero L; Herraiz C; Hernandez FJ; Rodriguez M; Borras I; Montero A; Bellon J; Tapia MC; Moreno F 《Human molecular genetics》1996,5(9):1383-1387
Non-syndromic X-linked deafness is highly heterogeneous. At least five
different clinical forms have been described, but only two loci have been
mapped. Here we report a Spanish family affected by a previously
undescribed X-linked form of hearing impairment. Deafness is non-
syndromic, sensorineural, and progressive. In affected males, the auditory
impairment is first detected at school age, affecting mainly the high
frequencies. Later it evolves to become severe to profound, involving all
frequencies for adulthood. Carrier females manifest a moderate hearing
impairment in the high frequencies, with the onset delayed to the fourth
decade of life. Deafness was assumed to be X- linked dominant, with
incomplete penetrance and variable expressivity in carrier females. The
family was genotyped for a set of microsatellite markers evenly spaced at
intervals of about 10 cM. We found evidence of linkage to markers in the
Xp22 region (maximum lod score of 5.30 at theta = 0.000 for DXS8036 and for
DXS8022). The position of the novel deafness locus (DFN6) was refined by
haplotype analysis. Mapping of the breakpoints in two critical recombinants
allowed us to define an interval for DFN6, delimited by DXS7108 on the
distal side and by DXS7105 on the proximal side, and spanning a genetic
distance of about 15 cM.
相似文献