全文获取类型
收费全文 | 1454篇 |
免费 | 88篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 129篇 |
妇产科学 | 16篇 |
基础医学 | 116篇 |
口腔科学 | 42篇 |
临床医学 | 212篇 |
内科学 | 347篇 |
皮肤病学 | 30篇 |
神经病学 | 60篇 |
特种医学 | 224篇 |
外科学 | 97篇 |
综合类 | 51篇 |
预防医学 | 98篇 |
眼科学 | 14篇 |
药学 | 70篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 44篇 |
出版年
2023年 | 5篇 |
2021年 | 8篇 |
2020年 | 11篇 |
2019年 | 13篇 |
2018年 | 18篇 |
2017年 | 13篇 |
2016年 | 9篇 |
2015年 | 24篇 |
2014年 | 25篇 |
2013年 | 30篇 |
2012年 | 33篇 |
2011年 | 27篇 |
2010年 | 48篇 |
2009年 | 52篇 |
2008年 | 39篇 |
2007年 | 28篇 |
2006年 | 31篇 |
2005年 | 32篇 |
2004年 | 27篇 |
2003年 | 35篇 |
2002年 | 37篇 |
2001年 | 32篇 |
2000年 | 22篇 |
1999年 | 31篇 |
1998年 | 88篇 |
1997年 | 86篇 |
1996年 | 91篇 |
1995年 | 63篇 |
1994年 | 57篇 |
1993年 | 51篇 |
1992年 | 30篇 |
1991年 | 35篇 |
1990年 | 19篇 |
1989年 | 44篇 |
1988年 | 33篇 |
1987年 | 45篇 |
1986年 | 34篇 |
1985年 | 43篇 |
1984年 | 28篇 |
1983年 | 22篇 |
1982年 | 18篇 |
1981年 | 19篇 |
1980年 | 10篇 |
1979年 | 5篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1976年 | 14篇 |
1975年 | 12篇 |
1971年 | 6篇 |
1966年 | 4篇 |
排序方式: 共有1553条查询结果,搜索用时 15 毫秒
121.
Harald zur Hausen received the Nobel price for Medicine in 2008 for his seminal research on human papilloma viruses and their association with anogenital diseases. On the basis of his work highly effective prophylactic vaccines have been developed. Clinical studies have shown nearly 100% seroconversion and an excellent safety profile as well as greater than 96% efficacy against HPV infection and premalignant dysplasia, induced by HPV types covered by the vaccine. Due to the convincing data of phase II and III clinical trials the introduction of HPV vaccination was recommended by health authorities and scientific committees in Germany. The development and availability of guidelines and evidence-based recommendations should support the introduction of the vaccine and widespread vaccination. 相似文献
122.
Lidocaine has been used in treatment of patients with refractory headache. Personal observations of neuropsychiatric toxicity in these patients led us to review our cases and the literature systematically for lidocaine side-effects, especially neuropsychiatric symptoms. In our series of 20 patients, side-effects were observed in all, the most frequent being neuropsychiatric (75%) and cardiological (50%). When reviewing published series on intravenous lidocaine use, reports of side-effects range from 0 to 100%, with neuropsychiatric symptoms being reported in 1.8–100%. Thirty-six case reports of lidocaine-induced psychiatric symptoms were also analysed. Psychiatric symptoms of toxicity were similar in most patients, despite their differing ages, pathologies, co-therapies and lidocaine dosages. In conclusion, lidocaine neuropsychiatric toxicity has a well-recognized stereotypical clinical presentation that is probably unrecognized in headache series. As lidocaine represents an emerging alternative therapy in headache, particularly in short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, clinicians and patients should be aware of the extent of this problem. 相似文献
123.
It has been shown that electrocardiograms which exhibit the multiple abnormalities described differ from electrocardiograms of the T1 type of coronary thrombosis. However, 16 of the 143 patients whose cases were reviewed had coronary thrombosis. In all 16 cases electrocardiograms showed the type of abnormality here recorded, and in none was the changing electrocardiographic picture of myocardial infarction found. Since 14 of these 16 patients had hypertension, the possibility must be kept in mind that antecedent or existing hypertension was the factor responsible for these abnormalities rather than cardiac infarction.It has been found that arterial hypertension was present in 124 of the 143 patients and that 11 of the remaining 19 patients had aortic valvular disease; from the evidence available preexistent hypertension was probable in at least 5 of the other 8 cases. Thus, in these cases there was present one or other of the two most important factors which determine hypertrophy of the left ventricle. In addition, it was found that left ventricular hypertrophy was present in all cases examined post mortem. It would seem justifiable, therefore, to conclude that these distinctive electrocardiographic abnormalities were characteristic of certain cases of left ventricular hypertrophy and, since arterial hypertension was by far the most frequent determining cause of that hypertrophy, that these electrocardiographic changes were practically diagnostic of hypertension. Further investigation regarding the relationship of these electrocardiographic abnormalities to left ventricular hypertrophy and to hypertension is in progress and will be reported upon later.1 相似文献
124.
125.
A Collier A W Patrick D A Hepburn D Bell M Jackson J Dawes B M Frier 《Diabetic medicine》1990,7(6):506-509
Insulin-induced hypoglycaemia in humans is associated with the rapid mobilization of leucocytes in peripheral blood. The aim of the present study was to determine whether neutrophil activation, manifested in plasma by neutrophil elastase concentration, occurs in response to insulin-induced hypoglycaemia. Acute hypoglycaemia (mean blood glucose 1.3 +/- 0.2 mmol l-1; mean +/- SD) was induced with intravenous insulin in 15 normal human subjects, and provoked an increase in the neutrophil count from 3.4 (range 1.9-6.5) to 10.7 (9.4-16.3) X 10(9) l-1 (p less than 0.001), and in the total leucocyte counts from 5.7 (4.1-8.1) to 12.8 (11.3-18.6) X 10(9) l-1 (p less than 0.001), with associated elevations in plasma neutrophil elastase concentration from 21 (12-34) to 29 (14-70) micrograms l-1 (p less than 0.05), and in total neutrophil elastase concentration from 5.90 (3.13-8.20) to 25.20 (23.00-52.00) mg l-1 (p less than 0.001). As neutrophil elastase is implicated in the development of vascular disease, this rise in response to hypoglycaemia may be of pathological importance in insulin-treated diabetic patients. 相似文献
126.
H Kaube YE Knight RJ Storer KL Hoskin A May PJ Goadsby 《Cephalalgia : an international journal of headache》1999,19(6):592-597
It remains an open question as to whether cortical spreading depression (CSD) is the pathophysiological correlate of the neurological symptoms in migraine with aura. In the experimental animal, CSD is an electrophysiological phenomenon mainly mediated via NMDA receptors. However, according to case reports in humans, visual aura in migraine can be alleviated by vasodilator substances, such as amyl nitrite and isoprenaline. There is also circumstantial evidence that brainstem nuclei (dorsal raphe nucleus and locus coeruleus) may play a pivotal role in the initiation of aura. In this study, CSD was elicited in alpha-chloralose anesthetized cats by cortical needle stab injury and monitored by means of laser Doppler flowmetry. Topical application of isoprenaline (0.1-1%) and amyl nitrite (0.05%) onto the exposed cortex had no effect on the elicitation or propagation of CSD. Also, after supracollicular transection, subsequent CSDs showed no differences in the speed of propagation and associated flow changes. We conclude from these data that--given CSD probably exists in humans during migraine--spreading neurological deficits during migraine aura are independent of brainstem influence and have a primarily neuronal rather than vascular mechanism of generation. 相似文献
127.
Gabriella M van Dijk Cindy Veenhof Francois Schellevis Harry Hulsmans Jan PJ Bakker Henk Arwert Jos HM Dekker Guus J Lankhorst Joost Dekker 《BMC musculoskeletal disorders》2008,9(1):95
Background
This study aims to contribute to the knowledge of the influence of comorbidity in OA. The objectives of the study were (i) to describe the prevalence of comorbidity and (ii) to describe the relationship between comorbidity (morbidity count, severity and the presence of specific diseases) and limitations in activities and pain in elderly patients with knee or hip OA using a comprehensive inventory of comorbidity. 相似文献128.
WS Lee PJ McKiernan J de Ville de Goyet MS Tanner PR John 《Acta paediatrica (Oslo, Norway : 1992)》2001,90(11):1352-1355
A 16-y-old boy who had undergone bone marrow transplantation for relapsed acute lymphoblastic leukaemia developed liver cirrhosis and refractory ascites, which did not respond to salt restriction, diuretics and abdominal paracentesis. Liver transplantation was not feasible because of poor nutritional status, pre-existing renal dysfunction and uncertainty about the prognosis of his leukaemia. The patient underwent a successful transjugular intrahepatic portosystemic shunt (TIPS), with immediate resolution of ascites, enabling cessation of diuretics and improvement in nutritional status. At 24 mo following TIPS there has been no re-accumulation of ascites. CONCLUSION: TIPS may have a role in the management of refractory ascites secondary to liver cirrhosis in selected children. 相似文献
129.
Russell SM Elliott R Forshaw D Kelly PJ Golfinos JG 《中国神经肿瘤杂志》2005,3(4):295-295
OBJECT: The goal of this study is to report the incidence and clinical evolution of neurological deficits in patients who underwent resection of gliomas confined to the parietal lobe. METHODS: Patient demographics, findings of serial neurological examinations, tumor location and neuroimaging characteristics, extent of resection, and surgical outcomes were tabulated by reviewing inpatient and office records, as well as all pre- and postoperative magnetic resonance (MR) images obtained in 28 consecutive patients who underwent resection of a glial neoplasm found on imaging studies to be confined to the parietal lobe. Neurological deficits were correlated with hemispheric dominance, location of the lesion within the superior or inferior parietal lobules, subcortical extension, and involvement of the postcentral gyms. The tumors were located in the dominant hemisphere in 18 patients (64%); had a mean diameter of 39 mm (range 14-69 mm); were isolated to the superior parietal lobule in six patients (21%) and to the inferior parietal lobule in eight patients (29%); and involved both lobules in 14 patients (50%). Gross-total resection, documented by MR imaging, was achieved in 24 patients (86%). Postoperatively, nine patients (32%) experienced new neurological deficits, whereas seven (25%) had an improvement in their preoperative deficit. A correlation was noted between larger tumors and the presence of neurological deficits both before and after resection. Postoperatively higher-level (association) parietal deficits were noted only in patients with tumors involving both the superior and inferior parietal lobules in the dominant hemisphere. At the 3-month follow-up examination, five of nine new postoperative deficits had resolved. CONCLUSIONS: Neurological deterioration and improvement occur after resection of parietal lobe gliomas. Parietal lobe association deficits, specifically the components of Gerstmann syndrome, are mostly associated with large tumors that involve both the superior and inferior parietal lobules of the dominant hemisphere. New hemineglect or sensory extinction was not noted in any patient following resection of lesions located in the nondominant hemisphere. Nevertheless, primary parietal lobe deficits (for example, a visual field loss or cortical sensory syndrome) occurred in patients regardless of hemispheric dominance. 相似文献
130.
Inward buckling of the dura at C1-2 may occasionally occur with hyperextension of the neck and can result in a difficult or unsuccessful puncture when the posterior lateral C1-2 approach is used for cervical myelography. In this circumstance, placement of the head in a neutral or slightly flexed position may widen the posterior subarachnoid space and facilitate the needle puncture. 相似文献