全文获取类型
收费全文 | 32021篇 |
免费 | 1333篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 413篇 |
儿科学 | 1098篇 |
妇产科学 | 876篇 |
基础医学 | 4874篇 |
口腔科学 | 736篇 |
临床医学 | 2388篇 |
内科学 | 6411篇 |
皮肤病学 | 661篇 |
神经病学 | 2742篇 |
特种医学 | 1480篇 |
外国民族医学 | 5篇 |
外科学 | 4448篇 |
综合类 | 116篇 |
一般理论 | 8篇 |
预防医学 | 2062篇 |
眼科学 | 855篇 |
药学 | 2484篇 |
中国医学 | 51篇 |
肿瘤学 | 1722篇 |
出版年
2022年 | 270篇 |
2021年 | 553篇 |
2020年 | 332篇 |
2019年 | 432篇 |
2018年 | 709篇 |
2017年 | 555篇 |
2016年 | 689篇 |
2015年 | 663篇 |
2014年 | 848篇 |
2013年 | 1133篇 |
2012年 | 1642篇 |
2011年 | 1696篇 |
2010年 | 968篇 |
2009年 | 776篇 |
2008年 | 1363篇 |
2007年 | 1410篇 |
2006年 | 1362篇 |
2005年 | 1348篇 |
2004年 | 1345篇 |
2003年 | 1259篇 |
2002年 | 1313篇 |
2001年 | 891篇 |
2000年 | 907篇 |
1999年 | 808篇 |
1998年 | 262篇 |
1997年 | 204篇 |
1996年 | 199篇 |
1992年 | 459篇 |
1991年 | 414篇 |
1990年 | 436篇 |
1989年 | 399篇 |
1988年 | 389篇 |
1987年 | 382篇 |
1986年 | 396篇 |
1985年 | 375篇 |
1984年 | 304篇 |
1983年 | 271篇 |
1979年 | 358篇 |
1978年 | 238篇 |
1977年 | 218篇 |
1975年 | 237篇 |
1974年 | 272篇 |
1973年 | 270篇 |
1972年 | 249篇 |
1971年 | 237篇 |
1970年 | 253篇 |
1969年 | 222篇 |
1968年 | 253篇 |
1967年 | 228篇 |
1966年 | 192篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Dorit Gräbsch 《MedR Medizinrecht》2006,24(1):VI-VIII
Ohne Zusammenfassung 相似文献
2.
Dorit Gräbsch 《MedR Medizinrecht》2006,24(4):VI-VIII
Ohne Zusammenfassung 相似文献
3.
Willemijn A K M Windt Atsua Tahara Alex C A Kluppel Dick de Zeeuw Robert H Henning Richard P E van Dokkum 《Journal of the renin-angiotensin-aldosterone system》2006,7(4):217-224
INTRODUCTION: Vasopressin, mainly through the V1a-receptor, is thought to be a major player in the maintenance of hyperfiltration. Its inhibition could therefore lead to a decrease in progression of chronic renal failure. To this end, the effect of the vasopressin V1a-receptor-selective antagonist, YM218, was studied on proteinuria and focal glomerulosclerosis in early and late intervention after 5/6 nephrectomy in rats, and compared with an angiotensin-converting enzyme inhibitor (ACE-I). MATERIALS AND METHODS: After 5/6 nephrectomy, early intervention was performed between week 2 and 10 thereafter with the V1a-receptor-selective antagonist (VRA, 10 mg/kg/day, n=10), enalapril (ACE-I, 10 mg/kg/day, n=9), or vehicle (n=8). Late intervention was performed in another group between week 6 and 12 with VRA (10 mg/kg/day, n=7), lisinopril (ACE-I, 5 mg/kg/day, n=7), or vehicle (n=7). RESULTS: In early intervention, proteinuria and focal glomerulosclerosis were significantly decreased by VRA compared to vehicle (44+7% and 59+8% respectively). ACE-I significantly decreased proteinuria (67+7%) and a trend towards a decrease in focal glomerulosclerosis was observed (30+18%). In late intervention, VRA did not decrease proteinuria and focal glomerulosclerosis compared to vehicle (21+20% and 0%, respectively), ACE-I significantly lowered proteinuria (92+2%) and a focal glomerulosclerosis (69+1%) lowering trend was observed. CONCLUSION: These results indicate that VRA may protect against early progression of renal injury after 5/6 nephrectomy, whereas its effectiveness seems limited in established renal damage. 相似文献
4.
Purpose. To present a model-dependent approach for the assessment of the in vivo drug dissolution profile based on in vitrodata for the multiple unit dosage form, as an alternative to the numerical method proposed in the study by Hayashi et al, Pharm. Res. 12:1333–1337 (1995).
Methods. The data for aspirin granules administered to healthy subjects obtained in the above mentioned study were re-evaluated. The subject dissolution system was considered to consist of two subsystems connected in series, i.e. the subsystem describing the gastric-emptying process and the subsystem describing the intestinal dissolution process. The frequency response method was used to model the subject dissolution system.
Results. The model in vivodissolution profile of aspirin, assessed as the integral of the model weighting function of the subject dissolution system, was in agreement with the in vivo cumulative absorption profile calculated by the Wagner-Nelson method.
Conclusions. Comparison of dynamic properties of the subject dissolution system with the subsystem describing the gastric-emptying process yielded quantitative confirmation of the decisive role of the gastric-emptying process in the in vivodrug dissolution after administration in the multi unit dosage form. 相似文献
5.
The present authors investigated the excretion, distribution and pharmacokinetics of the novel potential antirheumatic agent flobufen and its active metabolite after p.o. and i.v. doses of 2, 10 and 50 mg/kg administered to rats. The drug is resorbed well from the digestive tract and mostly it is metabolized to the principal metabolite M, which is only slowly excreted from the organism mainly by renal clearance. Within the whole dose range the kinetics of the drug is linear. Binding of flobufen and M to proteins is high (95-99%). The highest concentrations of radioactive metabolites (mostly M) were found in the plasma, liver, lungs, kidneys, connective tissue and inflammatory foci. The penetration of metabolites through the placenta and excretion in human milk are relatively important. 相似文献
6.
Dependence of blood clot lysis on the mode of transport of urokinase into the clot--a magnetic resonance imaging study in vitro 总被引:4,自引:0,他引:4
A Blinc G Planinsic D Keber O Jarh G Lahajnar A Zidans?k F Demsar 《Thrombosis and haemostasis》1991,65(5):549-552
Magnetic resonance imaging was employed to study the dependence of clot lysing patterns on two different modes of transport of urokinase into whole blood clots. In one group of clots (nonperfused clots, n1 = 10), access of urokinase to the fibrin network was possible by diffusion only, whereas in the other group (perfused clots, n2 = 10) bulk flow of plasma containing urokinase was instituted through occlusive clots by a pressure difference of 3.7 kPa (37 cm H2O) across 3 cm long clots with a diameter of 4 mm. It was determined separately that this pressure difference resulted in a volume flow rate of 5.05 +/- 2.4 x 10(-2) ml/min through occlusive clots. Perfused clots diminished in size significantly in comparison to nonperfused ones already after 20 min (p less than 0.005). Linear regression analysis of two-dimensional clot sizes measured by MRI showed that the rate of lysis was more than 50-times faster in the perfused group in comparison to the nonperfused group. It was concluded that penetration of the thrombolytic agent into clots by perfusion is much more effective than by diffusion. Our results might have some implications for understanding the differences in lysis of arterial and venous thrombi. 相似文献
7.
I Immonen K Friberg C Gr?nhagen-Riska E von Willebrand F Fyhrquist 《Acta ophthalmologica》1986,64(5):519-521
Angiotensin-converting enzyme (ACE) was studied immunohistochemically in conjunctival biopsies from 6 patients with systemic sarcoidosis, 4 patients with posterior non-sarcoid uveitis and in specimens from 4 patients with chalazion of the eyelid. Specimens with sarcoid granulomas showed intense ACE-positive immunoreactivity in epitheloid cells of the granuloma, whereas chalazion granulomas did not contain ACE-immunoreactivity. There was no difference in staining patterns between specimens without granulomas. Thus immunohistochemical staining for ACE may be of help in differentiating conjunctival granulomatous tissue of a chalazion from sarcoid granuloma. 相似文献
8.
9.
10.
Serum digoxin-like factor was detected in infants of diabetic mothers who were insulin-dependent or diet controlled. No statistical difference was found between the serum digoxin-like factor levels of the infants of diabetic mothers and the controls. 相似文献