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排序方式: 共有4025条查询结果,搜索用时 437 毫秒
81.
Wieneke Vlastra MD PhD Astrid C. van Nieuwkerk MD Anne-Sophie G.T. Bronzwaer PhD Adriaan Versteeg BSc Esther E. Bron PhD Wiro J. Niessen MD PhD Henk J.M.M. Mutsaerts MD PhD Björn J.P. van der Ster MSc Charles B.L.M. Majoie MD PhD Geert J. Biessels MD PhD Aart J. Nederveen MD PhD Mat J.A.P. Daemen MD PhD Matthias J.P. van Osch PhD Jan Baan MD PhD Jan J. Piek MD PhD Johannes J. Van Lieshout MD PhD Ronak Delewi MD PhD 《Journal of the American Geriatrics Society》2021,69(2):494-499
82.
Janssen R Sato H Grutters JC Ruven HJ du Bois RM Matsuura R Yamazaki M Kunimaru S Izumi T Welsh KI Nagai S van den Bosch JM 《American journal of respiratory and critical care medicine》2004,170(11):1185-1187
CC10 (CC16, uteroglobin) is a pulmonary protein postulated to play a counter regulatory role in sarcoidosis pathogenesis. The adenine38guanine (A38G) polymorphism of the encoding CC10 gene (SCGB1A1) is functional. Recently, an association between the low CC10 producing 38A allele and sarcoidosis susceptibility has been reported in Japanese patients from Hokkaido. The aim of the present study was to confirm this association in a clinically well characterized population of Dutch white and Kyoto Japanese patients with sarcoidosis and control subjects. No difference in genotype or allele frequency was found between patients with sarcoidosis and control subjects in either ethnic population. Remarkably, however, a significant difference was found between the control subjects from Kyoto and Hokkaido, but not between the Japanese groups of patients with sarcoidosis. Furthermore, review of previously published A38G genotyping results showed a consistent difference in CC10 A38G allele frequencies between whites and Japanese subjects. We conclude that the CC10 A38G polymorphism does not influence sarcoidosis susceptibility in Dutch whites or in Japanese subjects from Kyoto. This stresses the importance of studying the influence of polymorphisms on disease susceptibility in multiple ethnically and geographically distinct disease and control populations before reaching conclusions. 相似文献
83.
84.
Yvonne W. S. Jauw Dennis F. Heijtel Josée M. Zijlstra Otto S. Hoekstra Henrica C. W. de Vet Danielle J. Vugts Henk M. Verheul Ronald Boellaard Sonja Zweegman Guus A. M. S. van Dongen C. Willemien Menke-van der Houven van Oordt Adriaan A. Lammertsma Marc C. Huisman 《Molecular imaging and biology》2018,20(6):1025-1034
Purpose
Positron emission tomography (PET) with Zirconium-89 (Zr-89)-labeled antibodies can be used for in vivo quantification of antibody uptake. Knowledge about measurement variability is required to ensure correct interpretation. However, no clinical studies have been reported on measurement variability of Zr-89 immuno-PET. As variability due to low signal-to-noise is part of the total measurement variability, the aim of this study was to assess noise-induced variability of Zr-89 -immuno-PET using count-reduced clinical images.Procedures
Data were acquired from three previously reported clinical studies with [89Zr]antiCD20 (74 MBq, n?=?7), [89Zr]antiEGFR (37 MBq, n?=?7), and [89Zr]antiCD44 (37 MBq, n?=?13), with imaging obtained 1 to 6 days post injection (D0–D6). Volumes of interest (VOIs) were manually delineated for liver, spleen, kidney, lung, brain, and tumor. For blood pool and bone marrow, fixed-size VOIs were used. Original PET list mode data were split and reconstructed, resulting in two count-reduced images at 50 % of the original injected dose (e.g., 37 MBq74inj).Repeatability coefficients (RC) were obtained from Bland-Altman analysis on standardized uptake values (SUV) derived from VOIs applied to these images.Results
The RC for the combined manually delineated organs for [89Zr] antiCD20 (37 MBq74inj) increased from D0 to D6 and was less than 6 % at all time points. Blood pool and bone marrow had higher RC, up to 43 % for 37 MBq74inj at D6. For tumor, the RC was up to 42 % for [89Zr]antiCD20 (37 MBq74inj). For [89Zr]antiCD20, (18 MBq74inj), [89Zr]antiEGFR (18 MBq37inj), and [89Zr]antiCD44 (18 MBq37inj), measurement variability was independent of the investigated antibody.Conclusions
Based on this study, noise-induced variability results in a RC for Zr-89-immuno-PET (37 MBq) around 6 % for manually delineated organs combined, increasing up to 43 % at D6 for blood pool and bone marrow, assuming similar biodistribution of antibodies. The signal-to-noise ratio leads to tumor RC up to 42 %.85.
Current practices for viability testing of cryopreserved cord blood products: an international survey by the cellular therapy team of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative
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86.
87.
88.
The perceived impact of public involvement in palliative care in a provincial palliative care network in the Netherlands: a qualitative study
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89.
90.
The Consumer Quality Index in an accident and emergency department: internal consistency,validity and discriminative capacity
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Nanne Bos PhD Leontien M. Sturms PhD Rebecca K. Stellato MSc Augustinus J.P. Schrijvers PhD Henk F. van Stel PhD 《Health expectations》2015,18(5):1426-1438