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221.
van Leeuwaarde RS Vrede MA Henar F Does R Issa P Burke E Visser O Rijmen F Westermann AM 《Breast cancer research and treatment》2011,128(3):873-881
In this study, we describe the incidence, treatment, and outcome of breast cancer (BC) during the period 1994–2003 in the
South-American country of Surinam and compare these with those of BC in the Netherlands. Pathology reports and hospital charts
from all BC cases diagnosed between 1994 and 2004 were retrieved from Surinam’s single pathology laboratory and its five hospitals.
Data on demographics, tumor characteristics, treatment, and follow-up were gathered. We compared our data to BC statistics
of first generation immigrants from Surinam to the Netherlands. 421 patients were diagnosed with BC during the study period.
The age-adjusted incidence rate was 26 per 100,000 compared to 65/100,000 in first generation Surinamese women in the Netherlands.
The majority had a fairly advanced stage at presentation, with 60% of tumors larger than 2 cm, and 41.6% with lymph node involvement.
Because of the absence of radiotherapy facilities, local treatment in most patients was radical mastectomy. Adjuvant hormonal
therapy (51.6%) was administered more frequently than adjuvant chemotherapy (20.3%). A significant number of patients were
lost to follow-up, resulting in a median follow-up duration of only 23 months. The 5-year overall survival was 79%. BC incidence
in Surinam is low compared to that in the western world, but the advanced stage at diagnosis, the low utilization of systemic
adjuvant therapy, and the inadequate follow-up may lead to poor outcomes. A number of steps are underway to improve the level
of cancer care in Surinam. 相似文献
222.
Bernardo D Vallejo-Díez S Mann ER Al-Hassi HO Martínez-Abad B Montalvillo E Tee CT Murugananthan AU Núñez H Peake ST Hart AL Fernández-Salazar L Garrote JA Arranz E Knight SC 《European journal of immunology》2012,42(5):1337-1353
Dendritic cells (DCs) control the type and location of immune responses. Ulcerative colitis (UC) is considered a Th2 disease mediated by IL-13 where up to one third of patients can develop extraintestinal manifestations. Colonic biopsies from inflamed and noninflamed areas of UC patients were cultured in vitro and their supernatants were used to condition human blood enriched DCs from healthy controls. Levels of IL-13 in the culture supernatants were below the detection limit in most cases and the cytokine profile suggested a mixed profile rather than a Th2 cytokine profile. IL-6 was the predominant cytokine found in inflamed areas from UC patients and its concentration correlated with the Mayo endoscopic score for severity of disease. DCs conditioned with noninflamed culture supernatants acquired a regulatory phenotype with decreased stimulatory capacity. However, DCs conditioned with inflamed culture supernatants acquired a proinflammatory phenotype with increased expression of the skin-homing chemokine CCR8. These DCs did not have decreased T-cell stimulatory capacity and primed T cells with the skin-homing CLA molecule in an IL-6-dependent mechanism. Our results highlight the role of IL-6 in UC and question the concept of UC as a Th2 disease and the relevance of IL-13 in its etiology. 相似文献
223.
J.M. Abascal Junquera M. Hevia Suárez J.M. Abascal García R. Abascal García 《Actas urologicas espa?olas》2010,34(10):931
Figura 1. Rotura del extremo piélico en el mismo acto que obligó a colocar nuevo doble J izquierdo.Figura 2. Retirada del extremo piélico del catéter doble J con incrustación mediante acceso percutáneo, tras intento sin éxito en el mismo acto de retirada vía retrógada con ureterorrenoscopio.
224.
225.
226.
Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch 总被引:1,自引:0,他引:1
227.
Joaquín Cubiella Ángeles Pérez Aisa Miriam Cuatrecasas Pilar Díez Redondo Gloria Fernández Esparrach José Carlos Marín-Gabriel Leticia Moreira Henar Núñez M. Luisa Pardo López Enrique Rodríguez de Santiago Pedro Rosón José Miguel Sanz Anquela Xavier Calvet 《Gastroenterologia y hepatologia》2021,44(1):67-86
This positioning document, sponsored by the Asociación Española de Gastroenterología, the Sociedad Española de Endoscopia Digestiva and the Sociedad Española de Anatomía Patológica, aims to establish recommendations for the screening of gastric cancer (GC) in low incidence populations, such as the Spanish. To establish the quality of the evidence and the levels of recommendation, we used the methodology based on the GRADE system (Grading of Recommendations Assessment, Development and Evaluation). We obtained a consensus among experts using a Delphi method. The document evaluates screening in the general population, individuals with relatives with GC and subjects with GC precursor lesions (GCPL). The goal of the interventions should be to reduce GC related mortality. We recommend the use of the OLGIM classification and determine the intestinal metaplasia (IM) subtype in the evaluation of GCPL. We do not recommend to establish endoscopic mass screening for GC or Helicobacter pylori. However, the document strongly recommends to treat H. pylori if the infection is detected, and the investigation and treatment in individuals with a family history of GC or with GCPL. Instead, we recommend against the use of serological tests to detect GCPL. Endoscopic screening is suggested only in individuals that meet familial GC criteria. As for individuals with GCPL, endoscopic surveillance is only suggested in extensive IM associated with additional risk factors (incomplete IM and/or a family history of GC), after resection of dysplastic lesions or in patients with dysplasia without visible lesion after a high quality gastroscopy with chromoendoscopy. 相似文献