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91.
Eline Suzanne Smit Ciska Hoving Karen Schelleman-Offermans Robert West Hein de Vries 《Addictive behaviors》2014
Introduction
Despite their positive motivation to quit, many smokers do not attempt to quit or relapse soon after their quit attempt. This study investigated the predictors of successful and unsuccessful quit attempts among smokers motivated to quit smoking.Methods
We conducted secondary data analysis among respondents motivated to quit within 6 months, randomized to the control group (N = 570) of a Web-based smoking cessation intervention study. Using chi-square tests and ANOVA with Tukey post hoc comparisons, we investigated baseline differences by smoking status (successful quitter/relapse/persistent smoker) assessed after 6 weeks (N = 214). To identify independent predictors of smoking status, multivariate multinomial logistic regression analyses were conducted.Results
Successful quitters at 6-week follow-up (26%) had reported significantly higher baseline levels of self-efficacy than relapsers (45%) and persistent smokers (29%). Furthermore, both successful quitters and relapsers had reported a significantly higher baseline intention to quit than persistent smokers and successful quitters had reported significantly more preparatory planning at baseline than persistent smokers. Results from regression analyses showed that smokers' baseline intention to quit positively predicted quit attempts reported after 6 weeks, while self-efficacy positively predicted quit attempt success.Conclusions
Different factors appear to play a role in predicting quit attempts and their success. Whereas intention to quit only appeared to play a role in predicting quit attempts, self-efficacy was the main factor predicting quit attempt success. More research is needed to determine the role of preparatory planning and plan enactment and to investigate whether these findings can be replicated on the long term. 相似文献92.
93.
The lack of objective parameters makes the measurement of pain and the efficacy of pain treatment in patients with chronic
pain very difficult. We performed acupuncture therapy in fibromyalgia patients and established a combination of methods to
objectify pain measurement before and after therapy. The parameters corresponded to patients' self-report. Twenty-nine fibromyalgia
patients as defined by ACR-criteria (25 women, 4 men) with a mean age of 48.2±2.0 years and a mean disease duration of 6.1±1.0
years participated in the study. Pain levels and positive tender points were assessed using the visual analogue scale (VAS,
i.e., range 0–100 mm) and dolorimetry. Serotonin and substance P levels in serum and the serotonin concentration in platelets
were measured concomitantly. During acupuncture therapy no analgesic medication was allowed. The VAS scores decreased from
64.0±3.4 mm before therapy to 34.5±4.3 mm after therapy (P<0.001). Dolorimetry revealed a decreased number of tender points after therapy from 16.0±0.6 to 11.8±1.0, P<0.01. Serotonin levels decreased from 715.8±225.8 μg/1012 platelets to 352.4±47.9 μg/1012 platelets (P<0.01), whereas the serum concentration increased from 134.0±14.3 ng/ml to 171.2±14.6 ng/ml (P<0.01). Substance P levels in serum increased from 43.4±3.5 pg/ml to 66.9 ±8.8 pg/ml (P<0.01). Acupuncture treatment of patients with fibromyalgia was associated with decreased pain levels and fewer positive tender
points as measured by VAS and dolorimetry. This was accompanied by decreased serotonin concentration in platelets and an increase
of serotonin and substance P levels in serum. These results suggest that acupuncture therapy is associated with changes in
the concentrations of pain-modulating substances in serum. The preliminary results are objective parameters for acupuncture
efficacy in patients with fibromyalgia.
Received: 15 May 1997 相似文献
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Franco Giada Serge S Barold Alessandro Biffi Bruno De Piccoli Pietro Delise Nabil El-Sherif Michael R Gold Bulent Gorenek Blair Grubb Giuseppe Inama Josef Kautzner Luis Molina Brian Olshansky Antonio Pelliccia Gaetano Thiene Hein Wellens Christian Wolpert Paolo Zeppilli Antonio Raviele Hein Heidbuchel 《European journal of cardiovascular prevention and rehabilitation》2007,14(5):707-714
97.
Rigo Hoencamp Eric Vermetten Edward C.T.H. Tan Hein Putter Luke P.H. Leenen Jaap F. Hamming 《Injury》2014
Background
The North Atlantic Treaty Organization (NATO) coalition forces remain heavily committed on combat operations overseas. Understanding the prevalence and characteristics of battlefield injury of coalition partners is vital to combat casualty care performance improvement. The aim of this systematic review was to evaluate the prevalence and characteristics of battle casualties from NATO coalition partners in Iraq and Afghanistan. The primary outcome was mechanism of injury and the secondary outcome anatomical distribution of wounds.Methods
This systematic review was performed based on all cohort studies concerning prevalence and characteristics of battlefield injury of coalition forces from Iraq and Afghanistan up to December 20th 2013. Studies were rated on the level of evidence provided according to criteria by the Centre for Evidence Based Medicine in Oxford. The methodological quality of observational comparative studies was assessed by the modified Newcastle-Ottawa Scale.Results
Eight published articles, encompassing a total of n = 19,750 battle casualties, were systematically analyzed to achieve a summated outcome. There was heterogeneity among the included studies and there were major differences in inclusion and exclusion criteria regarding the target population among the included trials, introducing bias. The overall distribution in mechanism of injury was 18% gunshot wounds, 72% explosions and other 10%. The overall anatomical distribution of wounds was head and neck 31%, truncal 27%, extremity 39% and other 3%.Conclusions
The mechanism of injury and anatomical distribution of wounds observed in the published articles by NATO coalition partners regarding Iraq and Afghanistan differ from previous campaigns. There was a significant increase in the use of explosive mechanisms and a significant increase in the head and neck region compared with previous wars. 相似文献98.
Joost Colaris Max ReijmanJan Hein Allema Mark de VriesUlas Biter Rolf BloemCees van de Ven Jan Verhaar 《Injury》2014
Introduction
Although limitation of pronation/supination following both-bone forearm fractures in children is often attributed to an angular malunion, no clinical study has compared pronation/supination and angular malalignment of the same child by analysis of prospectively collected clinical data.Aim
The purpose of this trial is to explore whether limitation of pronation/supination can be predicted by the degree of angular malalignment in children who sustained a both-bone forearm fracture.Methods
In four Dutch hospitals, children aged ≤16 years with a both-bone forearm fracture were prospectively followed up consecutive children for 6–9 months. At the final follow-up, pronation/supination and angular malunion on radiographs were determined.Results
Between January 2006 and August 2010, a total of 410 children were prospectively followed up, of which 393 children were included for analysis in this study. The mean age of the children was 8.0 (±3.5) years, of which 63% were male and 40% fractured their dominant arm. The mean time to final examination was 219 (±51) days. Children with a metaphyseal both-bone fracture of the distal forearm with an angular malalignment of ≤15° had a 9–13% chance of developing a clinically relevant limitation (i.e., <50° of pronation and/or supination), while children with an angular malalignment of ≥16° had a 60% chance. Children with diaphyseal both-bone forearm fractures with ≤5° of angular malalignment had a 13% chance of developing a clinically relevant limitation, which showed no significant increase with a further increase of angular malalignment.Conclusions
Children who sustained a both-bone forearm fracture localised in the distal metaphysis have a higher chance of developing a clinically relevant limitation of forearm rotation in case of a more severe angular malalignment, while children with a diaphyseal both-bone forearm fracture had a moderate chance of limitation, irrespective of the severity of the angular malalignment. 相似文献99.
ABSTRACTBackground During the past two decades, the number and complexity of clinical trials have risen dramatically increasing the difficulty of choosing sites for inspection. FDA’s resources are limited and so sites should be chosen with care.Purpose To determine if data mining techniques and/or unsupervised statistical monitoring can assist with the process of identifying potential clinical sites for inspection.Methods Five summary-level clinical site datasets from four new drug applications (NDA) and one biologics license application (BLA), where the FDA had performed or had planned site inspections, were used. The number of sites inspected and the results of the inspections were blinded to the researchers. Five supervised learning models from the previous two years (2016–2017) of an on-going research project were used to predict site inspections results, i.e., No Action Indicated (NAI), Voluntary Action Indicated (VAI), or Official Action Indicated (OAI). Statistical Monitoring Applied to Research Trials (SMARTTM) software for unsupervised statistical monitoring software developed by CluePoints (Mont-Saint-Guibert, Belgium) was utilized to identify atypical centers (via a p-value approach) within a study.Finally, Clinical Investigator Site Selection Tool (CISST), developed by the Center for Drug Evaluation and Research (CDER), was used to calculate the total risk of each site thereby providing a framework for site selection. The agreement between the predictions of these methods was compared. The overall accuracy and sensitivity of the methods were graphically compared.Results Spearman’s rank order correlation was used to examine the agreement between the SMARTTM analysis (CluePoints’ software) and the CISST analysis. The average aggregated correlation between the p-values (SMARTTM) and total risk scores (CISST) for all five studies was 0.21, and range from ?0.41 to 0.50. The Random Forest models for 2016 and 2017 showed the highest aggregated mean agreement (65.1%) amongst outcomes (NAI, VAI, OAI) for the three available studies. While there does not appear to be a single most accurate approach, the performance of methods under certain circumstances is discussed later in this paper.Limitations Classifier models based on data mining techniques require historical data (i.e., training data) to develop the model. There is a possibility that sites in the five-summary level datasets were included in the training datasets for the models from the previous year’s research which could result in spurious confirmation of predictive ability. Additionally, the CISST was utilized in three of the five site selection processes, possibly biasing the data.Conclusion The agreement between methods was lower than expected and no single method emerged as the most accurate. 相似文献
100.
Kim Bo Min Hong Sae Rom Chun Hein Kim Sangwoo Shin Kyoung-Jin 《International journal of legal medicine》2020,134(3):853-861
International Journal of Legal Medicine - Hair shafts are one of the most common types of evidence at crime scenes, and mitochondrial DNA (mtDNA) has been analyzed as a valuable genetic marker for... 相似文献