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排序方式: 共有3511条查询结果,搜索用时 15 毫秒
101.
102.
Rachel Lampert Brian Olshansky Hein Heidbuchel Christine Lawless Elizabeth Saarel Michael Ackerman Hugh Calkins Mark Estes Mark Link Barry Maron Frank Marcus Melvin Scheinman Bruce Wilkoff Douglas Zipes Charles Berul Alan Cheng Ian Law Michelle Loomis Cheryl Barth Cynthia Brandt David Cannom 《Heart rhythm》2012,9(9):1577-1578
103.
104.
Mark W. Miller Annemarie F. Reardon Erika J. Wolf Lauren B. Prince Christina L. Hein 《Journal of traumatic stress》2013,26(1):71-76
This study examined the relative influences of posttraumatic stress disorder (PTSD), other psychopathology, and intimate partner alcohol and drug use on substance‐related problems in U.S. veterans (242 couples, N = 484). Hierarchical regression analyses revealed that partner alcohol and drug use severity explained more variance in veteran alcohol use and drug use (20% and 13%, respectively) than did veteran PTSD, adult antisocial behavior, or depression symptoms combined (6% for veteran alcohol use; 7% for veteran drug use). Findings shed new light on the influence of relationship factors on veteran alcohol and drug use and underscore the importance of couples‐oriented approaches to treating veterans with comorbid PTSD and substance abuse. 相似文献
105.
Joost W. Colaris Max Reijman Jan Hein Allema L. Ulas Biter Rolf M. Bloem Cees P. van de Ven Mark R. de Vries Albert J. H. Kerver Jan A. N. Verhaar 《Archives of orthopaedic and trauma surgery》2013,133(10):1407-1414
Introduction
This multicentre randomised controlled trial was designed to explore whether 6 weeks above-elbow cast (AEC) or 3 weeks AEC followed by 3 weeks below-elbow cast (BEC) cause similar limitation of pronation and supination in non-reduced diaphyseal both-bone forearm fractures in children.Materials and methods
Children were randomly allocated to 6 weeks AEC or to 3 weeks AEC followed by 3 weeks BEC. The primary outcome was limitation of pronation and supination after 6 months. The secondary outcomes were re-displacement of the fracture, complication rate, limitation of flexion and extension of wrist and elbow, cast comfort, cosmetics, complaints in daily life and assessment of radiographs.Results
A group of 23 children was treated with 6 weeks AEC and 24 children with 3 weeks AEC and 3 weeks BEC. The follow-up rate was 98 % with a mean follow-up of 7.0 months. The mean limitation of pronation and supination was 23.3 ± 22.0 for children treated with AEC and 18.0 ± 16.9 for children treated with AEC and BEC. The other study outcomes were similar in both groups.Conclusions
Early conversion to BEC is safe in the treatment of non-reduced diaphyseal both-bone forearm fractures in children.Level of evidence
Multicentre randomised controlled trial, Level II. 相似文献106.
Hein G. Gooszen Marc G. H. Besselink Hjalmar C. van Santvoort Thomas L. Bollen 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2013,398(6):799-806
Background
Acute pancreatitis remains an unpredictable, potentially lethal disease with significant morbidity and mortality rates. New insights in the pathophysiology of acute pancreatitis have changed management concepts. In the first phase, characterized by a systemic inflammatory response syndrome, organ failure, not related to infection but rather to severe inflammation, dominates the focus of treatment. In the second phase, secondary infectious complications largely determine the clinical outcome. As infection is associated with increased mortality in acute pancreatitis, numerous prophylactic strategies have been explored in the past two decades.Purpose
This review describes the strategies that have been developed to lower the infection rate, in an attempt to lower mortality. Antibiotic prophylaxis has been the subject of many RCT’s without showing convincing evidence of their efficacy. Probiotics, although theoretically capable of lowering the rate of infection, also had no effect on infectious complications, and consequently, no effective strategy to lower the rate of infectious complications is currently available. In the second part of this review, new approaches for necrosectomy that have been designed by different centers around the world are discussed. All the interventional techniques have in common their aim to lower the invasive character, hypothesizing that lowering the surgical trauma will improve survival and lower complication rates. Recent advances include postponing intervention as a strategy to facilitate necrosectomy and improve prognosis and the “step-up approach” in case of infected necrosis. The step-up approach includes percutaneous catheter drainage as the first step, to be followed by necrosectomy, either through a minimally invasive approach or by open necrosectomy, as the next step.Conclusions
All attempts to develop treatment strategies to lower the infection rate in acute pancreatitis have failed. Accumulating evidence is emerging to show that the combination of centralization, the use of catheter drainage as the first step of invasive treatment, and the development of minimally invasive techniques, improve the outlook for patients with infected necrosis. It is uncertain at this point in time as to which of the three effects is dominant in the improvement of prognosis. 相似文献107.
108.
Astrid M. B. Stoit Hein T. van Schie Dorine I. E. Slaats-Willemse Jan K. Buitelaar 《Journal of autism and developmental disorders》2013,43(12):2793-2806
Different views on the origin of deficits in action chaining in autism spectrum disorders (ASD) have been posited, ranging from functional impairments in action planning to internal models supporting motor control. Thirty-one children and adolescents with ASD and twenty-nine matched controls participated in a two-choice reach-to-grasp paradigm wherein participants received cueing information indicating either the object location or the required manner of grasping. A similar advantage for location cueing over grip cueing was found in both groups. Both accuracy and reaction times of the ASD group were indistinguishable from the control group. In contrast, movement times of the ASD group were significantly delayed in comparison with controls. These findings suggest that movement execution rather than action planning is deficient in ASD, and that deficits in action chaining derive from impairments in internal action models supporting action execution. 相似文献
109.
Ernst Hein Magdalena Nowak Olga Kiess Teresa Biermann Kristina Bayerlein Johannes Kornhuber Thomas Kraus 《Journal of neural transmission (Vienna, Austria : 1996)》2013,120(5):821-827
Invasive vagus nerve stimulation has been demonstrated to be an effective treatment in major depressive episodes. Recently, a novel non-invasive method of stimulating the vagus nerve on the outer canal of the ear has been proposed. In healthy subjects, a prominent fMRI BOLD signal deactivation in the limbic system was found. The present pilot study investigates the effects of this novel technique of auricular transcutaneous electric nerve stimulation in depressed patients for the first time. A total of 37 patients suffering from major depression were included in two randomized sham controlled add-on studies. Patients were stimulated five times a week on a daily basis for the duration of 2 weeks. On days 0 and 14, the Hamilton Depression Rating Scale (HAMD) and the Beck Depression Inventory (BDI) were assessed. In contrast to sham-treated patients, electrically stimulated persons showed a significantly better outcome in the BDI. Mean decrease in the active treatment group was 12.6 (SD 6.0) points compared to 4.4 (SD 9.9) points in the sham group. HAMD score did not change significantly in the two groups. An antidepressant effect of a new transcutaneous auricular nerve stimulation technique has been shown for the first time in this controlled pilot study. Regarding the limitations of psychometric testing, the risk of unblinding for technical reasons, and the small sample size, further studies are necessary to confirm the present results and verify the practicability of tVNS in clinical fields. 相似文献
110.
Martin Schoenthaler Daniel Schnell Konrad Wilhelm Daniel Schlager Fabian Adams Simon Hein Ulrich Wetterauer Arkadiusz Miernik 《World journal of urology》2016,34(4):471-477