全文获取类型
收费全文 | 1027篇 |
免费 | 47篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 55篇 |
妇产科学 | 12篇 |
基础医学 | 69篇 |
口腔科学 | 42篇 |
临床医学 | 156篇 |
内科学 | 229篇 |
皮肤病学 | 24篇 |
神经病学 | 17篇 |
特种医学 | 248篇 |
外科学 | 73篇 |
综合类 | 32篇 |
预防医学 | 50篇 |
眼科学 | 14篇 |
药学 | 79篇 |
肿瘤学 | 37篇 |
出版年
2021年 | 6篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 6篇 |
2016年 | 8篇 |
2015年 | 19篇 |
2014年 | 16篇 |
2013年 | 29篇 |
2012年 | 18篇 |
2011年 | 12篇 |
2010年 | 37篇 |
2009年 | 49篇 |
2008年 | 18篇 |
2007年 | 59篇 |
2006年 | 29篇 |
2005年 | 25篇 |
2004年 | 15篇 |
2003年 | 10篇 |
2002年 | 14篇 |
2001年 | 16篇 |
2000年 | 15篇 |
1999年 | 14篇 |
1998年 | 61篇 |
1997年 | 69篇 |
1996年 | 71篇 |
1995年 | 60篇 |
1994年 | 43篇 |
1993年 | 49篇 |
1992年 | 9篇 |
1991年 | 16篇 |
1990年 | 17篇 |
1989年 | 43篇 |
1988年 | 23篇 |
1987年 | 38篇 |
1986年 | 16篇 |
1985年 | 26篇 |
1984年 | 19篇 |
1983年 | 27篇 |
1982年 | 19篇 |
1981年 | 21篇 |
1980年 | 25篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1972年 | 8篇 |
1970年 | 2篇 |
1968年 | 4篇 |
1967年 | 5篇 |
1966年 | 3篇 |
排序方式: 共有1139条查询结果,搜索用时 15 毫秒
31.
Nagler JJ Cavileer TD Verducci JS Schultz IR Hook SE Hayton WL 《General and comparative endocrinology》2012,178(3):556-561
Estrogens are critical hormones involved in reproduction and need to bind to estrogen receptors in target organs for biological activity. Fishes have two distinct estrogen receptor subtypes, alpha (α) and beta (β), with variable combinations of additional isoforms of each subtype dependent on the history of genome duplication within a taxon. The comparative expression patterns of estrogen receptor isoforms during the female reproductive cycle will provide important insights into the unique function and importance of each. The purpose of this study was to measure the mRNAs for the four estrogen receptor isoforms (erα1, erα2, erβ1, erβ2) in the liver and ovary of adult, female rainbow trout over the course of an annual reproductive cycle. The expression of estrogen receptor mRNA isoforms was measured by quantitative real-time RT-PCR. Several reproductive indices (gonadosomatic index, maximum oocyte diameter, plasma estradiol-17β, plasma vitellogenin, and ovulation) were also quantified for comparison and used in a correlation analysis to examine any inter-relationships. Of the four isoforms, the expression of erα1 was highest in the liver, and had a significant positive correlation with liver erβ1 expression. Liver expression of erα2 mRNA was the lowest, but showed a significant positive correlation with maximum oocyte diameter in the ovary. The pattern of the erβ isoforms in liver was one of initially elevated mRNA expression followed by a gradual decrease as reproductive development proceeded. In the ovary the erβ1 isoform had the highest mRNA expression of all estrogen receptor isoforms, at the beginning of the reproductive cycle, but then decreased afterward. Both ovarian erβ isoforms had a significant positive correlation with one another. In contrast, erα2 mRNA expression showed a high maximum level in the ovary near the end of the cycle along with a significant positive correlation with plasma estradiol-17β levels; the highest gonadosomatic indices, maximum oocyte diameter, and vitellogenin levels occurred then too. 相似文献
32.
Vincent JJ Odekerken Teus van Laar Michiel J Staal Arne Mosch Carel FE Hoffmann Peter CG Nijssen Guus N Beute Jeroen PP van Vugt Mathieu WPM Lenders M Fiorella Contarino Marieke SJ Mink Lo J Bour Pepijn van den Munckhof Ben A Schmand Rob J de Haan P Richard Schuurman Rob MA de Bie 《Lancet neurology》2013,12(1):37-44
33.
K Guzińska-Ustymowicz J Kiśluk SJ Terlikowski A Pryczynicz K Niewiarowska M Ustymowicz M Hawryluk M Południewski A Kemona 《Advances in medical sciences》2013,58(2):221-226
PurposeWe identify the expression of PRL-3 in primary endometrioid endometrial cancer and metastases in relation to the clinicopathological characteristics.Material/MethodsThe study involved 30 patients with type I endometrial cancer. Twelve of them were diagnosed with metastases in various localization of abdomen. The PRL-3 expression was evaluated on the basis of immunohistochemistry results by the use of monoclonal antibody anti-PRL3 clone 3B6.ResultsThe intensity of PRL-3 expression in correlation with tumor stage was statistically significant (p = 0.024). The strongest reaction was noted in cases classified as a 1a and 1b stage defined by FIGO. The strength of PRL-3 expression is significantly associated with the degree of histological tumor grade (p = 0.035).ConclusionsThe strong expression of PRL-3 in the primary tumor that was significantly correlated with the grade and clinical stage suggest that PTP4A3 participates in the process of endometrial carcinogenesis. 相似文献
34.
35.
John W. K. Harrison Philip Thomas Asir Aster Graeme Wilkes Michael J. Hayton 《Hand (New York, N.Y.)》2013,8(4):450-453
Chronic exertional compartment syndrome (CECS) of the forearm may occur in sports requiring prolonged grip strength. CECS is a function of increasing pressure following muscle expansion within an inelastic tissue envelope resulting in compromise of perfusion and tissue function. Typical symptoms are pain, distal paraesthesia and loss of function. The condition is self-limiting and resolves completely between periods of activity. With no effective medical treatment, the gold standard remains four compartment open fasciotomy (Söderberg, J Bone Joint Surg Br 78(5):780–2, 1996; Wasilewski and Asdourian, Am J Sports Med 19(6):665–7, 1991). Minimally invasive techniques have been described (Croutzet et al., Tech Hand Up Extrem Surg 13(3):137–40, 2009) but have a risk of neuro-vascular injury, especially to the ulnar nerve while releasing the deep flexor compartment. We present a safe technique used with six elite rowers for mini-open fasciotomy to minimise scarring and time away from training while reducing the risk of neurovascular injury. 相似文献
36.
Athletic hand injuries present a unique challenge for the treating surgeon. Apart from a detailed understanding of the pathoanatomy of each injury, the surgeon also needs to appreciate the specific demands placed on the injured athlete in their sport in order to ensure an optimal outcome with a timely return to competition. In this article, the most commonly encountered acute hand injuries in athletes are reviewed, focussing on the assessment, principles of treatment and consideration of rehabilitation as pertinent to athletes. 相似文献
37.
38.
SJ Smith CV Rahman PA Clarke AA Ritchie TW Gould JH Ward KM Shakesheff RG Grundy R Rahman 《Annals of the Royal College of Surgeons of England》2014,96(7):495-501
Introduction
The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) remains less than 18 months despite radical surgery, radiotherapy and systemic chemotherapy. Surgical implantation of chemotherapy eluting wafers into the resection cavity has been shown to improve length of survival but the current licensed therapy has several drawbacks. This paper investigates in vivo efficacy of a novel drug eluting paste in glioblastoma.Methods
Poly(lactic-co-glycolic acid)/poly(ethylene glycol) (PLGA/PEG) self-sintering paste was loaded with the chemotherapeutic agent etoposide and delivered surgically into partially resected tumours in a flank murine glioblastoma xenograft model.Results
Surgical delivery of the paste was successful and practical, with no toxicity or surgical morbidity to the animals. The paste was retained in the tumour cavity, and preliminary results suggest a useful antitumour and antiangiogenic effect, particularly at higher doses. Bioluminescent imaging was not affected significantly by the presence of the paste in the tumour.Conclusions
Chemotherapy loaded PLGA/PEG paste seems to be a promising technology capable of delivering active drugs into partially resected tumours. The preliminary results of this study suggest efficacy with no toxicity and will lead to larger scale efficacy studies in orthotopic glioblastoma models. 相似文献39.
巨噬细胞迁移抑制因子最初是由于能抑制体外巨噬细胞随机迁移而被发现,现在它作为一种重要的调节因子参与一系列炎症性疾病过程.我们最近发现,巨噬细胞迁移抑制因子的缺失使一些由炎症介质诱发的白细胞-内皮细胞相互作用减弱,提示巨噬细胞迁移抑制因子在炎症反应中起作用的机制之一是促进白细胞聚集.…… 相似文献
40.