全文获取类型
收费全文 | 1220篇 |
免费 | 75篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 17篇 |
妇产科学 | 13篇 |
基础医学 | 113篇 |
口腔科学 | 19篇 |
临床医学 | 74篇 |
内科学 | 286篇 |
皮肤病学 | 15篇 |
神经病学 | 76篇 |
特种医学 | 94篇 |
外科学 | 220篇 |
综合类 | 24篇 |
预防医学 | 55篇 |
眼科学 | 39篇 |
药学 | 116篇 |
中国医学 | 7篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 14篇 |
2022年 | 37篇 |
2021年 | 68篇 |
2020年 | 40篇 |
2019年 | 53篇 |
2018年 | 69篇 |
2017年 | 42篇 |
2016年 | 42篇 |
2015年 | 26篇 |
2014年 | 61篇 |
2013年 | 71篇 |
2012年 | 126篇 |
2011年 | 116篇 |
2010年 | 51篇 |
2009年 | 48篇 |
2008年 | 71篇 |
2007年 | 85篇 |
2006年 | 70篇 |
2005年 | 46篇 |
2004年 | 41篇 |
2003年 | 26篇 |
2002年 | 19篇 |
2001年 | 6篇 |
2000年 | 14篇 |
1999年 | 11篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1976年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1943年 | 1篇 |
1942年 | 1篇 |
排序方式: 共有1298条查询结果,搜索用时 0 毫秒
91.
R. J. Lewandowski L. M. Kulik A. Riaz S. Senthilnathan M. F. Mulcahy R. K. Ryu S. M. Ibrahim K. T. Sato T. Baker F. H. Miller R. Omary M. Abecassis R. Salem 《American journal of transplantation》2009,9(8):1920-1928
Chemoembolization and other ablative therapies are routinely utilized in downstaging from United Network for Organ Sharing (UNOS) T3 to T2, thus potentially making patients transplant candidates under the UNOS model for end-stage liver disease (MELD) upgrade for hepatocellular carcinoma (HCC). This study was undertaken to compare the downstaging efficacy of transarterial chemoembolization (TACE) versus transarterial radioembolization. Eighty-six patients were treated with either TACE (n = 43) or transarterial radioembolization with Yttrium-90 microspheres (TARE-Y90; n = 43). Median tumor size was similar (TACE: 5.7 cm, TARE-Y90: 5.6 cm). Partial response rates favored TARE-Y90 versus TACE (61% vs. 37%). Downstaging to UNOS T2 was achieved in 31% of TACE and 58% of TARE-Y90 patients. Time to progression according to UNOS criteria was similar for both groups (18.2 months for TACE vs. 33.3 months for TARE-Y90, p = 0.098). Event-free survival was significantly greater for TARE-Y90 than TACE (17.7 vs. 7.1 months, p = 0.0017). Overall survival favored TARE-Y90 compared to TACE (censored 35.7/18.7 months; p = 0.18; uncensored 41.6/19.2 months; p = 0.008). In conclusion, TARE-Y90 appears to outperform TACE for downstaging HCC from UNOS T3 to T2. 相似文献
92.
93.
Background: Habitual cocaine use can lead to dilated cardiomyopathy (DCM) and sudden cardiac death. Based on prior clinical observations, we hypothesized that prior habitual cocaine use is a strong predictor of high defibrillation threshold (DFT) during implantable cardioverter-defibrillator (ICD) implant.
Methods: We reviewed the medical records of 130 consecutive patients undergoing initial ICD implantation or revision at Parkland Hospital and the Dallas VA Hospital, Dallas, TX, from January 2002 to November 2005. Patient characteristics and DFT data were collected retrospectively.
Results: The study group includes 11 patients (8.46%) who were identified as having a history of prior habitual cocaine use as demonstrated by history and urine toxicology; the rest (119 patients) form the control group. Cocaine-using patients tended to be younger (48.2 ± 10 vs 60.1 ± 12.3 years; P = 0.0026), were less likely to have coronary disease (36.3% vs 72.2%; P = 0.032), and had less comorbidity. The average DFT was 27.9 ± 7.8 J for all cocaine-using patients and 14.5 ± 4.1 J for noncocaine-using patients (P = 0.00018). In the cocaine-using group, three out of 11 patients required a subcutaneous array compared to none in the control group.
Conclusions: Our results suggest that patients with a history of habitual cocaine use may be at increased risk to have a high DFT during ICD implantation. This is the first study to demonstrate such association. ICD implantation in patients with this history should be planned with these findings in mind, as larger output generators or subcutaneous arrays might be required. 相似文献
Methods: We reviewed the medical records of 130 consecutive patients undergoing initial ICD implantation or revision at Parkland Hospital and the Dallas VA Hospital, Dallas, TX, from January 2002 to November 2005. Patient characteristics and DFT data were collected retrospectively.
Results: The study group includes 11 patients (8.46%) who were identified as having a history of prior habitual cocaine use as demonstrated by history and urine toxicology; the rest (119 patients) form the control group. Cocaine-using patients tended to be younger (48.2 ± 10 vs 60.1 ± 12.3 years; P = 0.0026), were less likely to have coronary disease (36.3% vs 72.2%; P = 0.032), and had less comorbidity. The average DFT was 27.9 ± 7.8 J for all cocaine-using patients and 14.5 ± 4.1 J for noncocaine-using patients (P = 0.00018). In the cocaine-using group, three out of 11 patients required a subcutaneous array compared to none in the control group.
Conclusions: Our results suggest that patients with a history of habitual cocaine use may be at increased risk to have a high DFT during ICD implantation. This is the first study to demonstrate such association. ICD implantation in patients with this history should be planned with these findings in mind, as larger output generators or subcutaneous arrays might be required. 相似文献
94.
95.
Shhadeh A Sair HI Kanamalla US 《Journal of vascular and interventional radiology : JVIR》2007,18(8):1051-1053
The present report describes an unusual case of a duplicated origin of the left vertebral artery from the aorta discovered incidentally in a young patient. Computed tomographic angiography followed by conventional angiography demonstrated this anomaly. Angiographic findings and vertebral artery embryogenesis and anomalies are discussed. 相似文献
96.
Nazir M Sultan M Riaz N Hafeez M Hussain H Ahmed I Schulz B Draeger S Jabbar A Krohn K Ashraf M Saleem M 《Journal of Asian natural products research》2011,13(11):1056-1060
Chromatographic purification of the extract of an endophytic fungal culture yielded depsitinuside (1), a new phenolic ester together with ergosterol (2) and (22E,24S)-24-methyl-5-α-cholesta-7,22-diene-3β,5,6β-triol (3). The structure of 1 was elucidated based on 1D, 2D NMR spectroscopy and high-resolution mass spectrometry, whereas the known compounds (2 and 3) were identified by (1)H NMR, mass spectrometry, and in comparison with the literature values. Compound 1 was evaluated for its enzyme inhibitory potential against acetylcholinesterase, butyrylcholinesterase and lipoxygenase, and was found inactive (10%-40% inhibition at a concentration of 2 mg/ml). 相似文献
97.
Hussain H Vouffo B Dongo E Riaz M Krohn K 《Journal of Asian natural products research》2011,13(6):547-550
One new bicyclic polyprenylated compound, dorstenpictanone (1), was isolated from Dorstenia picta. The structure of the new compound was elucidated by detailed spectroscopic analysis such as (1)H NMR, (13)C NMR, COSY, HMQC, HMBC, and HREIMS. The relative configuration of dorstenpictanone (1) was distinguished by comparative analysis of the NMR spectral data with known analogues together with the ROESY experiment. 相似文献
98.
Memon K Lewandowski RJ Kulik L Riaz A Mulcahy MF Salem R 《Seminars in radiation oncology》2011,21(4):294-302
The incidence of hepatocellular carcinoma is increasing. Most patients present beyond potentially curative options and are usually affected by underlying cirrhosis. In this scenario, transarterial therapies, such as radioembolization, are rapidly gaining acceptance as a potential therapy for hepatocellular carcinoma and liver metastases. Radioembolization is a catheter-based liver-directed therapy that involves the injection of micron-sized embolic particles loaded with a radioisotope by use of percutaneous transarterial techniques. Cancer cells are preferentially supplied by arterial blood and normal hepatocytes by portal venous blood; therefore, radioembolization specifically targets tumor cells with a high dose of lethal radiation and spares healthy hepatocytes. The antitumor effect mostly comes from radiation rather than embolization. The most commonly used radioisotope is yttrium-90. The commercially available devices are TheraSphere (glass based; MDS Nordion, Ottawa, Canada) and SIR-Sphere (resin based; Sirtex, Lane Cove, Australia). The procedure is performed on an outpatient basis. The incidence of complications is comparatively less than other locoregional therapies and may include nausea, fatigue, abdominal pain, hepatic dysfunction, biliary injury, fibrosis, radiation pneumonitis, gastrointestinal ulcers, and vascular injury. However, these complications can be avoided by meticulous pretreatment assessment, careful patient selection, and adequate dosimetry. This article focuses on both the technical and clinical aspects of radioembolization with emphasis on patient selection, uses and complications. 相似文献
99.
Shahbaz N Dar LR 《Journal of the College of Physicians and Surgeons--Pakistan : JCPSP》2008,18(9):586-587
The management of rupture of membranes at a nearly viability stage is still controversial. A case of a primigravida, who had rupture of membranes at 23 weeks of gestation, is reported. On conservative management, her pregnancy continued to 30 weeks and she delivered a normal fetus, who showed no abnormality till one year of follow-up. 相似文献
100.
Vrsalovic MM Pejsa V Veic TS Kolonic SO Ajdukovic R Haris V Jaksic O Kusec R 《Cancer biology & therapy》2007,6(9):1434-1436
Recent observations raise possibility for constitutively active, mutated JAK2 to modulate expression of RAS genes in CMPD. We analyzed the expression of AGT, renin, AT2R1 and ACE genes in normal and bone marrows of PV and ET patients with the respect to the presence of V617F JAK2 mutation. PV and ET had different expression patterns of major RAS components compared to normal BM which was primarily associated with the JAK2V617F mutation and less with PV or ET disease phenotype. However, AT2R1 was exclusively markedly upregulated only in PV, while ET showed moderate expression irrespective of the JAK2 mutational status. 相似文献