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31.
Diener Bernd; Becker Roger; Martus Hans-Jorg; Traiser Margarete; Steinberg Pablo; Oesch Franz 《Carcinogenesis》1995,16(3):633-636
Isolated rat liver parenchymal cells (PC) were co-cultured witha non-parenchymal rat liver epithelial cell line (NEC) or withan oval cell line. The homotypical gap junctional intercellularcommunication (GJIC) between the liver PC was measured aftermicroinjection of Lucifer Yellow by dye transfer. The rat liverPC were dye coupled between 87% and 100% for at least 1 weekin both co-cultures, in contrast to PC in monoculture betweenwhich no dye coupling was left after 1 week. When liver PC wereco-cultured with a transformed and tumorigenic NEC or with atransformed and tumorigenic oval cell line the homotypical GJICbetween the liver PC was drastically decreased with culturetime, and the PC were then compressed and displaced by the expansivegrowth of the transformed cell lines. The disturbance of theGJIC between normal cells by adjacent tumorigenic cells mightbe a new mechanism to explain the expansive growth of tumors. 相似文献
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Prof. Dr. Hans-Jörg Ehrlein Gert Thoma Oliver Keinke Christian Tsiamitas Volker Schumpelick 《Digestive diseases and sciences》1987,32(5):538-546
The aim of the study was to clarify whether nutrients are still capable of slowing gastric emptying following Roux-Y gastrectomy, as in normal dogs. Gastrointestinal motility and gastric emptying of acaloric and nutritive meals with different viscosities were measured in normal dogs and after a two-thirds Roux-Y gastrectomy. In gastrectomized dogs low-viscosity nutritive meals emptied unduly rapidly in an initial phase, although the frequency and spread of contractions, ie, the propulsive activity of the jejunal Roux limb were diminished. A slow emptying rate during the following period was due to a long-lasting inhibition of gastric and jejunal motility. Medium-viscosity nutritive meals emptied in gastrectomized dogs as slowly as in normal animals, but this effect was primarily caused by the meal viscosity and only secondarily by the nutrients. It is concluded that following Roux-Y gastrectomy a regulation of gastric emptying is preserved; however, the onset of an effective control is delayed, resulting in a rapid initial emptying of low-viscosity meals.Studies were supported by the Deutsche Forschungsgemeinschaft grant Eh 64/3-1. 相似文献
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CD164, a Novel Sialomucin on CD34+ and Erythroid Subsets, Is Located on Human Chromosome 6q21 总被引:1,自引:1,他引:1
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Zannettino Andrew C.W.; Buhring Hans-Jorg; Niutta Silvana; Watt Suzanne M.; Benton M. Ann; Simmons Paul J. 《Blood》1998,92(8):2613-2628
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A discrepancy exists on the effects of somatostatin on the absorption of nutrients: in humans, absorption was found to be reduced, whereas in rats no effects were observed. However, intestinal absorption might be influenced by the transit rate of contents. This was not considered in previous studies. Therefore, we investigated simultaneously the effects of somatostatin on the absorption of nutrients and on luminal transit. In five minipigs (44–62 kg), a 150-cm segment of the proximal jejunum was temporarily isolated by two cannulas and perfused with an oligomer diet (60% carbohydrate, 18% protein, and 22% fat). The perfusion rate was 2 kcal/min. Flow rate and mean transit time were determined by markers (Cr-EDTA and Cu-EDTA). Somatostatin was infused intravenously at rates of 0.5, 1.25, 2.5, and 5µg/kg/hr. In control experiments saline was administered intravenously. Somatostatin dose-dependently diminished flow rate of luminal contents and increased the transit time. At the largest dose of somatostatin (5µg/kg/hr) flow rate was reduced by 50% compared with control infusion of saline (1.0±0.4 vs 2.0±0.05 ml/min,P<0.05), and transit time was increased 3.6-fold (39.8±4.7 vs 11.2±4.9 min;P<0.05). Somatostatin also dose-dependently enhanced the absorption of nutrients and energy. However, the increase in absorption was small compared with the effects on flow rate and transit time. At the largest dose (5µg/kg/hr) absorption of energy, carbohydrate, protein, and fat was enhanced only by 9.7%, 7.0%, 5.2%, and 15.3%, respectively (49.9 vs 40.2%, 50.9 vs 43.9%, 67.3 vs 62.1%, and 30.1 vs 14.8% during saline infusion;P<0.05). Results indicate that the major effects of somatostatin consist in a marked reduction of flow rate and a delay of luminal transit. The small increase in absorption was caused by the delay in transit and the prolonged contact of the nutrients with the mucosa. Therefore, in absorption studies, effects on transit need to be considered. 相似文献