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991.
Manig Fartasch Thomas L. Diepgen Hans Drexler Peter Elsner Swen Malte John Sibylle Schliemann 《Journal der Deutschen Dermatologischen Gesellschaft》2015,13(6):594-606
Job‐related hand dermatitis heads up the list of reported occupational diseases. So‐called skin products – understood to mean protective creams, skin cleansers and skin care products – are used for the primary and secondary prevention of job‐ related hand dermatitis. In the interests of evidence‐based medicine, the only preventive measures and/or occupational skin products that should be used are those whose potential uses and efficacy are underpinned by scientific research. To this end, the Arbeitsgemeinschaft für Berufs‐ und Umweltdermatologie e.V. (Working Group for Occupational and Environmental Dermatology, ABD) of the DDG (German Dermatological Society) and the Deutsche Gesellschaft für Arbeits‐ und Umweltmedizin (German Society for Occupational and Environmental Medicine, DGAUM) have summed up the latest scientific findings and recommendations in the updated guideline. The benefit of the combined application of protective creams and skin care products in the primary and secondary prevention of work‐related contact dermatitis has been widely confirmed by recent clinical‐epidemiological studies. The guideline clearly explains the necessity of demonstrating the efficacy of protective creams and cleansing products by means of in vivo methods in the sense of repetitive applications. Transferable standardised testing systems designed to examine the irritation potential and thus the compatibility of occupational skin cleansers and the reduction of irritation by protective skin creams have now been developed and validated by multicentre studies for skin protection creams and cleansers. The status of the current assessment of the safety of occupational skin products is also summarised. 相似文献
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993.
994.
New Fixed‐Dose Combinations of Fenofibrate/Simvastatin Therapy Significantly Improve the Lipid Profile of High‐Risk Patients with Mixed Dyslipidemia Versus Monotherapies 下载免费PDF全文
995.
996.
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation 总被引:10,自引:3,他引:10 下载免费PDF全文
Holler E Rogler G Herfarth H Brenmoehl J Wild PJ Hahn J Eissner G Schölmerich J Andreesen R 《Blood》2004,104(3):889-894
Single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene resulting in a diminished nuclear factor-kappaB (NF-kappaB) response to bacterial cell wall products have been associated with an increased incidence of Crohn disease. To assess a possible contribution of NOD2/CARD15 mutations to graft-versus-host disease (GvHD) and complications following allogeneic stem cell transplantation, we retrospectively typed DNA from donor/recipient pairs in 169 consecutive patients receiving transplants from related or unrelated donors. Mutated alleles were observed in 21% of patients and in 14% of donors. Cumulative incidence of 1-year, transplant-related mortality rose from 20% in donor/recipient pairs without mutated SNPs to 49% in pairs with recipient mutations (P =.03) and 59% in pairs with donor mutations (P <.005), and was highest in 12 pairs with mutated alleles in both donor and recipients (83%; P <.001). Similar associations were observed for severe overall and severe gastrointestinal GvHD. The impact of NOD2/CARD15 mutations was more prominent for HLA-identical sibling transplantations but was also observed in unrelated donor transplantation. Mutations proved to be independent risk factors for transplant-related mortality. Our findings indicate a major role of monocyte/macrophage dysfunction in the pathophysiology of GvHD and strongly suggest a future risk assessment or even donor selection through NOD2/CARD15 typing. 相似文献
997.
Role of angiogenic factors/cell adhesion markers in serum of cirrhotic patients with hepatopulmonary syndrome 下载免费PDF全文
998.
Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment 下载免费PDF全文
Sarah Raevens Anja Geerts Christophe Van Steenkiste Xavier Verhelst Hans Van Vlierberghe Isabelle Colle 《Liver international》2015,35(6):1646-1660
Hepatopulmonary syndrome and portopulmonary hypertension are cardiopulmonary complications, which are not infrequently seen in patients with liver disease and/or portal hypertension. These entities are both clinically and pathophysiologically different: the hepatopulmonary syndrome is characterized by abnormal pulmonary vasodilation and right‐to‐left shunting resulting in gas exchange abnormalities, whereas portopulmonary hypertension is caused by pulmonary artery vasoconstriction leading to hemodynamic failure. As both hepatopulmonary syndrome and portopulmonary hypertension are associated with significantly increased morbidity and mortality, and as these patients are commonly asymptomatic, all liver transplantation candidates should be actively screened for the presence of these two complications. The aim of is this review is to provide an overview on the hepatopulmonary syndrome and portopulmonary hypertension with primary focus on diagnosis and recent knowledge regarding pathogenesis and therapeutic targets. 相似文献
999.
Viktor Bandler Wilhelm Perls F. Schaefer Theodor Baer Fritz Juliusberg Walther Pick H. Hamburger Fritz Schaefer Max Joseph Hans Burkhard Harald Boas H. Hamburger Marg Stern Max Leibkind Max Winkler 《Archives of dermatological research》1919,125(3):444-474
Ohne Zusammenfassung 相似文献
1000.
Robert Bell Reinier Beeuwkes Hans Erik B?tker Sean Davidson James Downey David Garcia-Dorado Derek J. Hausenloy Gerd Heusch Borja Ibanez Masafumi Kitakaze Sandrine Lecour Robert Mentzer Tetsuji Miura Lionel Opie Michel Ovize Marisol Ruiz-Meana Rainer Schulz Richard Shannon Malcolm Walker Jakob Vinten-Johansen Derek Yellon 《Basic research in cardiology》2012,107(6):1-7