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81.
应用激光多普勒血流仪测量比较津白Ⅱ号小鼠三个部位皮肤的血流,观察HDZ对血流的影响,评价了HDZ的体内热增敏作用。结果发现,同一小鼠不同部位的血流是不同的,同一部位的连续6天结果无何区别。但同部位小鼠间的血流差别可达1倍以上。提示了预测放、化、热疗的疗效时,监测个体血流的前后变化有重要意义。2.5mg/kg以上的HDZ可以明显降低血流75%左右。HDZ与高温联合应用时对肿瘤显示了热增敏效应。 相似文献
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84.
应用抗猪囊虫抗原的单克隆抗体反向间接血凝试验(IHAT),对临床确诊的囊虫病患者进行了血清循环抗原(CAg)的检测,阳性率为51.14%(67/131)。对19例脑型囊虫病患者同时测定了血清和脑脊液中的CAg,阳性率分别为47.36%和78.94%,总阳性率为84.21%。对治疗0.53后的19例患者检测时,血清和脑脊液中CAg均呈阴性反应,而检测抗体仍呈阳性反应。50例正常人、49例其它寄生虫病及5例其它脑部疾病患者脑脊液的CAg均呈阴性反应。结果提示:测定CAg对囊虫病活动性感染的诊断及疗效判定均具有一定的实用价值。 相似文献
85.
心导纳微分环,肺导纳微分环最大向量正常值及其临床意义 总被引:2,自引:0,他引:2
本文报道3-50岁214例心导纳微分环(CADL)和肺导纳微分环(PADL)最大向量振幅及方位正常值,结果随增龄变化振幅递减,方位递增,多数男>女,部分组间有差异。48例左向右分流先心病环体最大向量与肺动脉压之间呈平行关系,并探讨其临床意义。 相似文献
86.
Forty cases of severe pancreatitis confirmed and treated by surgery were studied. In order to have a retrospective observation, we compared the clinical and laboratory data of 28 severe cases with that of 72 mild cases treated conservatively and found that in some cases neither Ranson nor Bank criteria were reliable in predicting the severity. We also found that frank peritonitis and bloody ascites with elevated amylase level were very good indication of pancreatic necrosis and hemorrhage. It was the author's opinion to explore early within 48 hrs after onset, using both drainage and open lesser sac lavage in most severe cases of pancreatitis. 相似文献
87.
Jian-ya Zhou Fa-di Tang Guo-gen Mao Jie Shao Yan Wang Ru-lian Bian 《浙江大学学报(医学版)》2003,32(4):315-8, 326
OBJECTIVE: To study the effect of eucalyptus globulus oil on the activity of nuclear factor-kappaB(NF-kappaB) in THP-1 cell line. METHODS: THP-1 cells were cultured with or without eucalyptus globulus oil at different concentrations (1, 10, 100 mg x L(-1), 30 min) before being stimulated with lipopolysaccharide (LPS, 1 mg x L(-1), 30 min). The location of NF-kappaB p65 subunit (NF-kappaB/p65) in THP-1 cells was detected by indirect immunofluorescence and laser scanning confocal microscope. The expression of NF-kappaB/p65 in nuclei was measured by Western-blot analysis. RESULT: The FITC-label NF-kappaB/p65 was mainly located in the nuclei after THP-1 cells were stimulated with LPS. Whereas, no fluorescence were seen in the nuclei of cells pretreated with eucalyptus globulus oil. This effect on NF-kappaB/p65 nuclear translocation was in a concentration dependent manner. CONCLUSION: Eucalyptus globulus oil inhibits the nuclear translocation of NF-kappaB induced by LPS in THP-1 cells. 相似文献
88.
Variants of B cell lymphoma 6 (BCL6) and marked atopy 总被引:3,自引:0,他引:3
Chaker N Adra PS Gao XQ Mao Beverly W Baron S. Pauker T. Miki T. Shirakawa JM Hopkin 《Clinical genetics》1998,54(4):362-364
89.
胸腺切除后血清乙酰胆碱受体抗体改变及与疗效关系 总被引:2,自引:0,他引:2
随访23例因重症肌无力行胸腺切除术的病人。运用灵敏度高、特异性强的BAS—ELISA法检测手术前、后血清乙酰胆碱受体抗体(AchR抗体)水平,所得结果均进行统计学分析。23例病人胸腺切除后,18例临床症状改善,有效率78%。术后14例(61%)病人血清AchR抗体水平下降,统计结果表明,手术前后血清AchR抗体水平差异有显著性(P<0.05),但与症状改善无关(P>0.05)。手术前后血清AchR抗体水平不影响疗效(P>0.05)。 相似文献
90.
Oxidant-scavenging activities of ampicillin and sulbactam and their effects on neutrophil functions. 总被引:1,自引:1,他引:0
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Luminol-enhanced luminescence is a method used to measure formation of reactive oxygen intermediates important in the ability of neutrophils to kill microbes. Several studies have demonstrated that under some conditions of incubation, ampicillin can inhibit neutrophil-derived luminol-enhanced luminescence. We evaluated the mechanism(s) by which ampicillin inhibited the luminescent response of stimulated neutrophils. We also investigated sulbactam, a beta-lactamase inhibitor which has been given in combination with ampicillin and other beta-lactam antibiotics to increase their spectra, for possible similar effects. Both ampicillin and sulbactam attenuated luminol-enhanced luminescence by approximately 40%. Superoxide production was not prevented by added ampicillin, nor was superoxide scavenged by it. Myeloperoxidase reacts with H2O2 and Cl- to generate OCl-, which is believed to be the oxidizer of luminol that is primarily responsible for enhancement of neutrophil-derived luminescence. Hydroxyl radicals (HO.), which may also oxidize luminol, resulting in luminescence, can be formed from O2- and H2O2 via either myeloperoxidase-dependent (involving intermediate OCl-) or myeloperoxidase-independent (through a metal ion catalyst) reactions. Ampicillin scavenged H2O2 and OCl- and prevented 95% of Fenton reaction-generated HO. from reacting with 5,5-dimethyl-1-pyrroline-N-oxide. Sulbactam was found to scavenge OCl- and HO., but less avidly than ampicillin did. Neither ampicillin nor sulbactam inhibited myeloperoxidase activity. Sublethal concentrations of sulbactam had no significant effect on neutrophil killing of Staphylococcus aureus and Escherichia coli. Our results demonstrate a mechanism(s) by which ampicillin inhibits luminol-enhanced luminescence from stimulated neutrophils, namely, through scavenging of the oxidant(s) primarily responsible for the generation of luminescence. 相似文献