全文获取类型
收费全文 | 5720篇 |
免费 | 471篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 215篇 |
妇产科学 | 206篇 |
基础医学 | 785篇 |
口腔科学 | 61篇 |
临床医学 | 559篇 |
内科学 | 1137篇 |
皮肤病学 | 68篇 |
神经病学 | 695篇 |
特种医学 | 98篇 |
外科学 | 512篇 |
综合类 | 63篇 |
一般理论 | 9篇 |
预防医学 | 817篇 |
眼科学 | 146篇 |
药学 | 344篇 |
中国医学 | 6篇 |
肿瘤学 | 424篇 |
出版年
2024年 | 21篇 |
2023年 | 172篇 |
2022年 | 248篇 |
2021年 | 503篇 |
2020年 | 274篇 |
2019年 | 335篇 |
2018年 | 311篇 |
2017年 | 217篇 |
2016年 | 229篇 |
2015年 | 243篇 |
2014年 | 284篇 |
2013年 | 332篇 |
2012年 | 476篇 |
2011年 | 389篇 |
2010年 | 199篇 |
2009年 | 153篇 |
2008年 | 252篇 |
2007年 | 291篇 |
2006年 | 228篇 |
2005年 | 201篇 |
2004年 | 170篇 |
2003年 | 135篇 |
2002年 | 113篇 |
2001年 | 29篇 |
2000年 | 19篇 |
1999年 | 31篇 |
1998年 | 25篇 |
1997年 | 19篇 |
1996年 | 19篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 14篇 |
1991年 | 23篇 |
1990年 | 13篇 |
1989年 | 12篇 |
1988年 | 17篇 |
1987年 | 20篇 |
1986年 | 9篇 |
1985年 | 16篇 |
1984年 | 7篇 |
1982年 | 7篇 |
1980年 | 8篇 |
1977年 | 6篇 |
1976年 | 9篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1972年 | 7篇 |
1969年 | 6篇 |
1968年 | 7篇 |
排序方式: 共有6199条查询结果,搜索用时 15 毫秒
11.
12.
Fürstenau Daniel Haneke Hannah Spies Claudia Walz Tim Schewina Kai Höft Moritz Mörgeli Rudolf Balzer Felix 《Zeitschrift fur Gesundheitswissenschaften》2022,30(1):99-110
Journal of Public Health - The purpose of this paper is to investigate the implementation of value-based care principles in the context of frailty in the perioperative process, highlighting the... 相似文献
13.
Racine Nicole Byles Hannah Killam Teresa Ereyi-Osas Whitney Madigan Sheri 《Maternal and child health journal》2022,26(5):994-1004
Maternal and Child Health Journal - Adverse childhood experiences (ACEs) are associated with poor physical and mental health outcomes in pregnancy, prompting many care agencies to ask about ACEs as... 相似文献
14.
15.
Annie N Apple Kevin E Neuzil Hannah M Phelps Bingshan Li Harold N Lovvorn III 《Journal of pediatric surgery》2021,56(6):1135-1141
BackgroundWilms tumor (WT) affects Black children disproportionately. Genetic aberrations within WT specimens that contribute to this disparity have not been reported.MethodsThe Therapeutically Applied Research to Generate Effective Treatments (TARGET) database was queried for WT patient and genomic features. Clinical and genetic variables were compared by race.ResultsWithin the discovery set (enriched for adverse events; N = 94 White, 19 Black, 14 Other/unreported patients), Black children were more likely to present with advanced stage disease (p = 0.019). Within the validation set (primarily a random sampling of NWTS-5; N = 360 White, 92 Black, 72 Other/Unreported), Black children appeared older at diagnosis (p = 0.050), had decreased median follow-up time (p<0.0005) and were over-represented (17.4%) relative to the concurrent U.S. Census (12.8%). Among the 37 target genes sequenced, ACTB (p = 0.030) and DICER1 (p = 0.026) mutations were more common in Black patient specimens, whereas DGCR8 (p = 0.041) mutations were more common in White patient specimens. White patient specimens were more likely to contain one or multiple targeted mutations (p = 0.026).ConclusionWithin the TARGET database, Black children were over-represented and harbored WT specimens containing more frequent ACTB and DICER1 mutations. In contrast, WT from White children contained overall more mutations in targeted genes and specifically in DGCR8.Level of EvidenceIII. 相似文献
16.
17.
Fong KW Ohlsson A Hannah ME Grisaru S Kingdom J Cohen H Ryan M Windrim R Foster G Amankwah K 《Radiology》1999,213(3):681-689
PURPOSE: To determine and compare the diagnostic performance of fetal middle cerebral (MCA), renal (RA), and umbilical (UA) arterial Doppler ultrasonography (US) for prediction of adverse perinatal outcome in suspected intrauterine growth restriction (IUGR). MATERIALS AND METHODS: Two hundred ninety-three small-for-gestational age fetuses (24-39 weeks at recruitment and US-estimated weight or abdominal circumference below 10th percentile) were prospectively examined with Doppler US of the UA, MCA, and RA. Clinicians were blinded to MCA and RA Doppler measurements. RESULTS: Seventy-six fetuses (25.9%) had at least one major or minor adverse perinatal outcome. Major outcomes included stillbirth, neonatal death, neurologic complication, and necrotizing enterocolitis. The MCA pulsatility index (PI), compared with the UA PI and RA PI, was more sensitive (72.4% vs 44.7% and 8.3%) but less specific (58.1% vs 86.6% and 92.6%) in predicting adverse outcome. The UA PI had the highest positive likelihood ratio (ratio, 3.3); the MCA PI had the lowest negative likelihood ratio (ratio, 0.48). When gestational age at the first Doppler US examination was less than 32 weeks, the MCA PI had a sensitivity of 95.5% and negative predictive value of 97.7% for major adverse outcome (negative likelihood ratio, 0.10). CONCLUSION: In suspected IUGR, while an abnormal UA PI is a better predictor of adverse perinatal outcome than an abnormal MCA or RA PI, a normal MCA PI may help to identify fetuses without major adverse perinatal outcome, especially before 32 weeks gestational age. 相似文献
18.
19.
Kurt B Stevenson Matthew Samore James Barbera Elizabeth Hannah James W Moore Julie L Gerberding Peter Houck 《American journal of health-system pharmacy》2004,61(8):787-792
PURPOSE: Pharmacist involvement in antimicrobial use at small rural hospitals in four Western states was studied. METHODS: Surveys were mailed in July 2000 to hospitals with a daily patient census of <150 in Idaho, Nevada, Utah, and eastern Washington. RESULTS: Seventy-seven (77%) of 100 hospitals returned completed surveys. Only 5% of the hospitals had onsite pharmacists 24 hours per day. An onsite pharmacist was present for a median of 26 hours per week in hospitals without 24-hour pharmacist coverage (range, 0-116 hr/wk). Many hospitals (71%) had policies for monitoring or controlling antimicrobial use, but only 28% had a system capable of monitoring compliance with such policies. Few hospitals had systems for recommending changes in antimicrobial selection on the basis of susceptibility test results (27%) or for monitoring physician compliance with dosage recommendations by pharmacists (21%). Onsite pharmacist hours were significantly associated with pharmacists being involved in the initial ordering of antibiotics and providing active oversight of antimicrobial use. There was a negative correlation between onsite pharmacist hours and use of third-generation cephalosporins and carbapenems. CONCLUSION: A survey showed that rural hospital pharmacists in four Western states spent relatively little time monitoring and influencing antimicrobial prescribing. 相似文献
20.
Miriam B. G. Morrell Claudia Alvarez‐Florez Aiqian Zhang Eugenie S. Kleinerman Hannah Savage Enrica Marmonti Minjeong Park Angela Shaw Keri L. Schadler 《Pediatric blood & cancer》2019,66(9)
Recent studies in mouse models of cancer have shown that exercise improves tumor vascular function, thereby improving chemotherapy delivery and efficacy. However, the mechanisms underlying this improvement remain unclear and the effect of exercise on Ewing sarcoma (ES), a pediatric bone and soft tissue cancer, is unknown. The effect of exercise on tumor vascular hyperpermeability, which inversely correlates with drug delivery to the tumor, has also not been evaluated. We hypothesized that exercise improves chemotherapy efficacy by enhancing its delivery through improving tumor vascular permeability. We treated ES‐bearing mice with doxorubicin with or without moderate treadmill exercise. Exercise did not significantly alter ES tumor vessel morphology. However, compared to control mice, tumors of exercised mice had significantly reduced hyperpermeability, significantly decreased hypoxia, and higher doxorubicin penetration. Compared to doxorubicin alone, doxorubicin plus exercise inhibited tumor growth more efficiently. We evaluated endothelial cell sphingosine‐1‐phosphate receptors 1 and 2 (S1PR1 and S1PR2) as potential mediators of the improved vascular permeability and increased function afforded by exercise. Relative to tumors from control mice, vessels in tumors from exercised mice had increased S1PR1 and decreased S1PR2 expression. Our results support a model in which exercise remodels ES vasculature to reduce vessel hyperpermeability, potentially via modulation of S1PR1 and S1PR2, thereby improving doxorubicin delivery and inhibiting tumor growth more than doxorubicin alone does. Our data suggest moderate aerobic exercise should be tested in clinical trials as a potentially useful adjuvant to standard chemotherapy for patients with ES. 相似文献