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Introduction Probiotics are live microorganisms which confer a health benefit on the host. Saccharomyces boulardii, a yeast, has been found to be an effective probiotic in double-blind placebo-controlled randomized clinical studies.
Materials and methods We reviewed the established mechanisms of actions and clinical efficacy in children of S. boulardii.
Conclusions The mechanisms of action of S. boulardii depend mainly on the inhibition of some bacterial toxins, anti-inflammatory effects, and on stimulating effects on the intestinal
mucosa such as trophic effects on the brush border enzymes and immunostimulatory effects. At present, in pediatric populations,
there is evidence that S. boulardii is beneficial for the treatment of acute gastroenteritis and the prevention of antibiotic-associated diarrhea. More data
are needed in other indications such as traveller’s diarrhea, Helicobacter pylori eradication, and inflammatory bowel disease. S. boulardii is a yeast strain that has been extensively studied in vitro and in vivo. Recent data have opened the door for new therapeutic
indications.
An erratum to this article can be found at 相似文献
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Eric Guillemard Marion Poirel Florent Schfer Laurent Quinquis Caroline Rossoni Christian Keicher Frank Wagner Hania Szajewska Frdric Barbut Muriel Derrien Peter Malfertheiner 《Nutrients》2021,13(9)
Helicobacter pylori (Hp) eradication therapy alters gut microbiota, provoking gastrointestinal (GI) symptoms that could be improved by probiotics. The study aim was to assess the effect in Hp patients of a Test fermented milk containing yogurt and Lacticaseibacillus (L. paracasei CNCM I-1518 and I-3689, L. rhamnosus CNCM I-3690) strains on antibiotic associated diarrhea (AAD) (primary aim), GI-symptoms, gut microbiota, and metabolites. A randomised, double-blind, controlled trial was performed on 136 adults under 14-day Hp treatment, receiving the Test or Control product for 28 days. AAD and GI-symptoms were reported and feces analysed for relative and quantitative gut microbiome composition, short chain fatty acids (SCFA), and calprotectin concentrations, and viability of ingested strains. No effect of Test product was observed on AAD or GI-symptoms. Hp treatment induced a significant alteration in bacterial and fungal composition, a decrease of bacterial count and alpha-diversity, an increase of Candida and calprotectin, and a decrease of SCFA concentrations. Following Hp treatment, in the Test as compared to Control group, intra-subject beta-diversity distance from baseline was lower (padj = 0.02), some Enterobacteriaceae, including Escherichia-Shigella (padj = 0.0082) and Klebsiella (padj = 0.013), were less abundant, and concentrations of major SCFA (p = 0.035) and valerate (p = 0.045) were higher. Viable Lacticaseibacillus strains were detected during product consumption in feces. Results suggest that, in patients under Hp treatment, the consumption of a multi-strain fermented milk can induce a modest but significant faster recovery of the microbiota composition (beta-diversity) and of SCFA production and limit the increase of potentially pathogenic bacteria. 相似文献
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Susanne Halken Antonella Muraro Debra de Silva Ekaterina Khaleva Elizabeth Angier Stefania Arasi Hasan Arshad Henry T. Bahnson Kirsten Beyer Robert Boyle George du Toit Motohiro Ebisawa Philippe Eigenmann Kate Grimshaw Arne Hoest Carla Jones Gideon Lack Kari Nadeau Liam O’Mahony Hania Szajewska Carina Venter Valérie Verhasselt Gary W. K. Wong Graham Roberts European Academy of Allergy Clinical Immunology Food Allergy Anaphylaxis Guidelines Group 《Pediatric allergy and immunology》2021,32(5):843-858
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Debra de Silva Susanne Halken Chris Singh Antonella Muraro Elizabeth Angier Stefania Arasi Hasan Arshad Kirsten Beyer Robert Boyle Philippe Eigenmann Kate Grimshaw Arne Hoest Carla Jones Gideon Lack Hania Szajewska George du Toit Carina Venter Valérie Verhasselt Graham Roberts 《Pediatric allergy and immunology》2020,31(3):243-249