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排序方式: 共有1957条查询结果,搜索用时 15 毫秒
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Vriz Olga Palatini Paolo Mos Lucio AlSergani Hani Vendramin Igor Livi Ugolino Antonini-Canterin Francesco Magne Julien 《The international journal of cardiovascular imaging》2021,37(5):1659-1668
The International Journal of Cardiovascular Imaging - Aortic valve stenosis (AS) shares similarities with the atherosclerotic process but little is known about the effect of the mechanical... 相似文献
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Parathyroid hormone 1–34 enhances extracellular matrix deposition and organization during flexor tendon repair 下载免费PDF全文
Daniel J. Lee Richard D. Southgate Youssef M. Farhat Alayna E. Loiselle Warren C. Hammert Hani A. Awad Regis J. O'Keefe 《Journal of orthopaedic research》2015,33(1):17-24
Parathyroid hormone (PTH) 1–34 is known to enhance fracture healing. Tendon repair is analogous to bone healing in its dependence on the proliferation and differentiation of mesenchymal stem cells, matrix formation, and tissue remodeling.1,2,3 We hypothesized that PTH 1–34 enhances tendon healing in a flexor digitorum longus (FDL) tendon repair model. C57Bl/6J mice were treated with either intraperitoneal PTH 1–34 or vehicle‐control (PBS). Tendons were harvested at 3–28 days for histology, gene expression, and biomechanical testing. The metatarsophalangeal joint range of motion was reduced 1.5–2‐fold in PTH 1–34 mice compared to control mice. The gliding coefficient, a measure of adhesion formation, was 2–3.5‐fold higher in PTH 1–34 mice. At 14 days post‐repair, the tensile strength was twofold higher in PTH 1–34 specimens, but at 28 days there were no differences. PTH 1–34 mice had increased fibrous tissue deposition that correlated with elevated expression of collagens and fibronectin as seen on quantitative PCR. PTH 1–34 accelerated the deposition of reparative tissue but increased adhesion formation. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:17–24, 2015. 相似文献
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Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders 总被引:21,自引:0,他引:21
Matsumoto I Lee DM Goldbach-Mansky R Sumida T Hitchon CA Schur PH Anderson RJ Coblyn JS Weinblatt ME Brenner M Duclos B Pasquali JL El-Gabalawy H Mathis D Benoist C 《Arthritis and rheumatism》2003,48(4):944-954
OBJECTIVE: Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose-6-phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients. Previous experiments have revealed significant titers of anti-GPI antibodies in the serum of many patients with rheumatoid arthritis (RA). We evaluated the generality of these observations in cohorts of patients with 12 different arthritic and chronic autoimmune diseases and in population-matched healthy control subjects. METHODS: Anti-GPI antibodies were assayed in 811 individual serum samples by enzyme-linked immunosorbent assay with 2 forms of GPI, recombinant and native. Results were confirmed by immunoblotting. RESULTS: Several patients had significantly elevated anti-GPI antibody titers, but without the prevalence or the specificity reported previously. Only 15% of RA patients had anti-GPI antibodies (range 12-29% in different cohorts), with a higher prevalence in patients with active disease. Psoriatic arthritis, undifferentiated arthritis, and spondylarthropathy patients also displayed anti-GPI antibodies at similar frequencies (12-25%). Similar titers were detected in a proportion (5-10%) of control subjects or patients with Crohn's disease or sarcoidosis. Very high titers were found in rare cases of RA and systemic lupus erythematosus. CONCLUSION: No disease-specific pattern of antibody positivity to GPI was apparent. While the antibody-mediated mechanism at play in the mouse model may exemplify a generic mechanism for some forms of arthritis in humans, GPI itself does not appear to be a target common to the majority of RA patients. 相似文献
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Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: A case report 下载免费PDF全文
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Ahmed MS Ibrahim Hani H Sinno Ali Izadpanah Joshua Vorstenbosch Tassos Dionisopoulos Mark K Markarian Bernard T Lee Samuel J Lin 《CANADIAN JOURNAL OF PLASTIC SURGERY》2015,23(2):103-107