全文获取类型
收费全文 | 57272篇 |
免费 | 5048篇 |
国内免费 | 3185篇 |
专业分类
耳鼻咽喉 | 855篇 |
儿科学 | 852篇 |
妇产科学 | 642篇 |
基础医学 | 7662篇 |
口腔科学 | 1119篇 |
临床医学 | 6842篇 |
内科学 | 9713篇 |
皮肤病学 | 884篇 |
神经病学 | 3356篇 |
特种医学 | 3109篇 |
外国民族医学 | 21篇 |
外科学 | 6124篇 |
综合类 | 6292篇 |
现状与发展 | 13篇 |
一般理论 | 5篇 |
预防医学 | 3295篇 |
眼科学 | 1320篇 |
药学 | 5682篇 |
40篇 | |
中国医学 | 2440篇 |
肿瘤学 | 5239篇 |
出版年
2024年 | 173篇 |
2023年 | 870篇 |
2022年 | 2155篇 |
2021年 | 3031篇 |
2020年 | 2202篇 |
2019年 | 2023篇 |
2018年 | 2080篇 |
2017年 | 1858篇 |
2016年 | 1855篇 |
2015年 | 2699篇 |
2014年 | 3122篇 |
2013年 | 3045篇 |
2012年 | 4319篇 |
2011年 | 4576篇 |
2010年 | 2892篇 |
2009年 | 2316篇 |
2008年 | 3018篇 |
2007年 | 2977篇 |
2006年 | 2754篇 |
2005年 | 2600篇 |
2004年 | 1901篇 |
2003年 | 1734篇 |
2002年 | 1457篇 |
2001年 | 1173篇 |
2000年 | 1151篇 |
1999年 | 1173篇 |
1998年 | 752篇 |
1997年 | 757篇 |
1996年 | 603篇 |
1995年 | 533篇 |
1994年 | 495篇 |
1993年 | 316篇 |
1992年 | 400篇 |
1991年 | 320篇 |
1990年 | 311篇 |
1989年 | 300篇 |
1988年 | 267篇 |
1987年 | 235篇 |
1986年 | 210篇 |
1985年 | 166篇 |
1984年 | 107篇 |
1983年 | 81篇 |
1982年 | 48篇 |
1981年 | 64篇 |
1980年 | 47篇 |
1979年 | 41篇 |
1978年 | 29篇 |
1977年 | 40篇 |
1976年 | 57篇 |
1975年 | 31篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
Han Wang Hui Ding Bo-wen Ouyang Zhenduo Yang Tan Zhong Hongming Fan Xingwu Zhong 《Eye (London, England)》2020,34(12):2328
ObjectivesTo investigate the effect of corneal stromal pocket irrigation after small-incision lenticule extraction (SMILE) on visual acuity, intraocular pressure (IOP), corneal parameters and complications after surgery.MethodsA total of 242 eyes of 121 patients undergoing SMILE were enrolled in this prospective controlled study, and it was designed for one eye to randomly undergo SMILE with balanced salt solution irrigation of the corneal stromal pocket, while the other eye was not. The uncorrected distance visual acuity (UDVA) and slit lamp examination were recorded at 1 hour, 1 day, 1 week, and 1 month. Postoperative corneal density, corneal biomechanical, corneal endothelial cell number, and anterior OCT images were compared at 1 day, 1 week, and 1 month.ResultsCompared with the nonirrigation group, the irrigation group showed significantly higher UDVA at 1 day postoperatively (P < 0.05), but there was no significant difference during the rest of the postoperative period (1 hour, 1 week, and 1 month). In addition, no significant differences were found in IOP, corneal density, corneal biomechanics, corneal endothelial cells, and corneal morphology. No visual decline or severe postoperative complications were found in the patients in this study.ConclusionsInterlamellar irrigation did not affect IOP, corneal parameters, morphology, complications, or UDVA at 1 hour, 1 week, and 1 month after the operation, but it may promote UDVA 1 day after the operation.Subject terms: Refractive errors, Outcomes research, Surgery 相似文献
14.
目的 探讨膝骨美节炎(KOA)患者美节滑液中IL 17的水平与疾病严重程度的相关性,为临床诊治KOA 提供新思路及新方法。方法 选取2017年1月?2018年12月南充市中心医院康复科收治的15。例膝骨美节炎患者作 为实验组,同时纳入30例健康志愿者作为对照组。实验组釆用视觉模拟量表(VAS)评价膝关节的疼痛程度,采用膝关 节学会评分系统(KSS)评价膝关节的功能及采用Kellgren Lawrence (KL)分级系统评价膝关节X线严重程度,通过 ELISA试验检测两组膝关节滑液中IL17的水平。采用Spearman相关分析KOA患者关节滑液中IL 17水平与膝关节 疼痛程度、膝关节功能及X线严重程度的相关性。结果 实验组关节滑液中IL17的水平明显高于对照组(P <0. 05). IL 17水平在滕美节炎KL分级之间比较,差异无统计学差异(P>0. 05)。IL 17的水平与膝关节VAS评分呈正相关 (P=0. 914,P<0.01),IL 17的水平与KSS呈负相关(P=—0. 847,P<0. 01), IL 17的水平与KL分级无相关性(r = 0.050,P= 0.545)。结论 IL 17可反应膝骨关节炎患者疼痛程度及功能损伤程度,但不能反映疾病的X线严重程度。 IL 17可作为一个生化指标反应膝关节炎疼痛程度及膝关节功能,临床通过减少关节滑液中IL 17,可能会减轻膝骨关 节炎患者的临床症状。 相似文献
15.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
16.
17.
18.
H J Kim C H Kang Y T Kim S-W Sung J H Kim S M Lee C-G Yoo C-T Lee Y W Kim S K Han Y-S Shim J-J Yim 《The European respiratory journal》2006,28(3):576-580
Although surgical lung resection could improve prognosis in some patients with multidrug-resistant tuberculosis (MDR-TB), there are no reports on the optimal candidates for this surgery. The aim of the present study was to elucidate the prognostic factors for surgery in patients with MDR-TB. Patients who underwent lung resection for the treatment of MDR-TB between March 1993 and December 2004 were included in the present study. Treatment failure was defined as greater than or equal to two of the five cultures recorded in the final 12 months of treatment being positive, any one of the final three cultures being positive, or the patient having died during treatment. The variables that affected treatment outcomes were identified through univariate and multivariate logistic regression analysis. In total, 79 patients with MDR-TB were included in the present study. The treatment outcomes of 22 (27.8%) patients were classified as failure. A body mass index <18.5 kg x m(-2), primary resistance, resistance to ofloxacin and the presence of a cavitary lesion beyond the range of the surgical resection were associated with treatment failure. Low body mass index, primary resistance, resistance to ofloxacin and cavitary lesions beyond the range of resection are possible poor prognostic factors for surgical lung resection in multidrug-resistant tuberculosis patients. 相似文献
19.
Neprilysin基因在大鼠体外培养骨髓基质细胞中的表达 总被引:1,自引:1,他引:0
目的探讨人Neprilysin基因在小鼠MSCs中的表达情况。方法分离培养小鼠MSCs,采用分子克隆技术构建Neprilysin—pEGFP重组质粒,将此Neprilysin—pEGFP重组质粒用脂质体转染进MSCs中,在荧光倒置显微镜下观察该基因在MSCs中的表达效率。结果经酶切鉴定得到系列正确的重组Neprilysin—pEGFP。Neprilysin可在MSCs中表达且通过脂质体传染的效率是20%。结论获得了表达Neprilysin基因的骨髓基质细胞,为进一步探讨将该细胞用于阿尔茨海默病基因治疗的可能性研究提供了技术基础。 相似文献
20.
JM Martín† L Calduch† C Monteagudo‡ I Molina† D Ramón† V Alonso† E Jordᆠ《Journal of the European Academy of Dermatology and Venereology》2006,20(4):428-431
Cutaneous plasmacytosis is a rare disorder characterized by a benign proliferation of mature plasma cells that appears as multiple dark-brown to purplish skin lesions, often associated with polyclonal hypergammaglobulinaemia. We present the case of a 55-year-old Caucasian man who suffered from a cutaneous plasmacytosis associated with two different carcinomas. Cutaneous plasmacytosis seems to be a reactive process because most cases reported are not associated with any apparent underlying disease. Nevertheless, because few reported cases were associated with malignancies, screening of additional neoplasms would be justified. 相似文献