全文获取类型
收费全文 | 11444篇 |
免费 | 551篇 |
国内免费 | 91篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 309篇 |
妇产科学 | 124篇 |
基础医学 | 1629篇 |
口腔科学 | 241篇 |
临床医学 | 639篇 |
内科学 | 3281篇 |
皮肤病学 | 392篇 |
神经病学 | 801篇 |
特种医学 | 430篇 |
外科学 | 1937篇 |
综合类 | 46篇 |
一般理论 | 1篇 |
预防医学 | 357篇 |
眼科学 | 182篇 |
药学 | 703篇 |
中国医学 | 22篇 |
肿瘤学 | 937篇 |
出版年
2023年 | 69篇 |
2022年 | 145篇 |
2021年 | 213篇 |
2020年 | 129篇 |
2019年 | 164篇 |
2018年 | 220篇 |
2017年 | 181篇 |
2016年 | 190篇 |
2015年 | 224篇 |
2014年 | 273篇 |
2013年 | 359篇 |
2012年 | 552篇 |
2011年 | 629篇 |
2010年 | 361篇 |
2009年 | 327篇 |
2008年 | 580篇 |
2007年 | 625篇 |
2006年 | 614篇 |
2005年 | 660篇 |
2004年 | 694篇 |
2003年 | 667篇 |
2002年 | 709篇 |
2001年 | 250篇 |
2000年 | 233篇 |
1999年 | 263篇 |
1998年 | 168篇 |
1997年 | 127篇 |
1996年 | 152篇 |
1995年 | 125篇 |
1994年 | 103篇 |
1993年 | 86篇 |
1992年 | 196篇 |
1991年 | 170篇 |
1990年 | 163篇 |
1989年 | 156篇 |
1988年 | 135篇 |
1987年 | 120篇 |
1986年 | 117篇 |
1985年 | 109篇 |
1984年 | 88篇 |
1983年 | 80篇 |
1982年 | 46篇 |
1981年 | 45篇 |
1980年 | 46篇 |
1979年 | 83篇 |
1978年 | 52篇 |
1977年 | 45篇 |
1975年 | 30篇 |
1973年 | 32篇 |
1970年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
Yuji Maruyama Shigeo Yamauchi Hidetsugu Ogasawara Hajime Imura Masami Ochi Kazuo Shimizu 《Annals of thoracic and cardiovascular surgery》2006,12(1):60-62
Surgical treatment for subacute pulmonary arterial thromboembolism has previously been considered to be inappropriate. We undertook a pulmonary arterial thrombectomy and removal of a floating right heart thrombus in a patient who had been symptomatic for over a month. The pulmonary arterial pressure, which had been equal to the systemic pressure preoperatively, decreased gradually and almost normalized one month postoperatively. Pulmonary perfusion scintigraphy revealed a dramatic improvement and the patient returned to normal life activities. 相似文献
13.
Kuri Suzuki Daisuke Nishimi Hajime Morioka Masaharu Takanami 《International journal of urology》2007,14(4):370-372
The presence of blood in the ejaculate is called hematospermia or hemospermia. While often perceived as a symptom of little significance, hematospermia can cause great concern to men who experience it. We report an unusual case of hematospermia associated with pelvic arteriovenous malformation (AVM). A 60-year-old man who visited our hospital complaining of hematospermia and pollakisuria was found to have AVM and aneurysmal changes in the left side of the pelvis using computed tomography (CT). The patient was treated with steel coil embolization of the left inferior gluteal artery, and after the procedure the hematospermia and pollakisuria remained absent without flare-ups. 相似文献
14.
Aoyama Takao Yamamoto Koujirou Kotaki Hajime Sawada Yasufumi Iga Tatsuji 《Pharmaceutical research》1997,14(11):1601-1606
Purpose. The locomotive activity changes after intravenous (i.v.) administration of methylphenidate (MPD) in rats were pharmacodynamically analyzed.
Methods. MPD concentration in plasma, MPD concentration and dopamine (DA) level in striatal dialysate collected by microdialysis method, and the locomotor activity after i.v. administration of MPD (2, 5 and 10 mg/kg doses) were used for the analysis.
Results. The transport of MPD from plasma to the interstitial fluid in the brain could be expressed by the linear two-compartment model. The clockwise hysteresis between the MPD concentration and the DA level in the dialysate could be explained by the pharmacodynamic model considering Michaelis-Menten type reuptake process of the extracellular DA into the terminal of the dopaminergic nerve and its competitive inhibition by the extracellular MPD. The inhibition constant (Ki) of MPD for DA reuptake was estimated to be 41.3 ± 73.8 nM (mean ± SE), which was closely consistent with the in vitro value after correction with dialysis recovery. The relationship between DA level in dialysate and locomotor activity was expressed by the Emax model considering two contrary effects, hyperkinesia and stereotypy. The bi-phasic locomotor activity-time profiles after high dose of MPD could be represented by this model.
Conclusions. The developed model made it possible to explain the tolerance in DA increase and the complicated locomotive change induced by MPD, and may be useful for other DA reuptake inhibitors, such as amphetamine and methamphetamine. 相似文献
15.
Chronological changes in the complement system in sepsis 总被引:6,自引:0,他引:6
The time courses of serum complement levels and the severity of sepsis were compared in two groups of septic patients, one in which the patients survived (surviving group) and one in which they did not (nonsurviving group). The components of the complement system, namely, C3a, C4a, C5a, CH50, C3, C4, and C5, were measured at several points in time after the diagnosis of sepsis had been established. A 2-antibody radioimmunoassay was used to measure C3a, C4a, and C5a; the latex agglutination test was used to measure C3 and C4; nephelometry was used to measure C5; and Meyer's 50% hemolysis method was used to measure CH50. Following the diagnosis of sepsis, the levels of CH50, C3, and C4 were significantly lower in the nonsurviving than the surviving group, while the levels of C3a and C4a were significantly higher in the nonsurviving than the surviving group. The C5a levels were significantly higher in the nonsurviving than the surviving group, although no significant intergroup differences were subsequently noted. These results suggest that the serum levels of C3a, C4a, C5a, CH50, C3, and C4 could serve as indices of the severity of sepsis. Thus, monitoring the complement system may be useful for predicting the outcome of patients with sepsis. 相似文献
16.
F Tanioka H Ishihara K Isozaki A Matsuki T Tsubo T Kudo T Oyama 《Masui. The Japanese journal of anesthesiology》1990,39(7):858-863
We investigated effects of total body hyperthermia (TBH) on endocrine and hemodynamic responses. A total of five treatments were performed in five patients with gastric cancer under neuroleptanesthesia with morphine followed by 0.2 to 0.4% enflurane. TBH was extracorporeally induced with veno-venous shunt incorporating with heat exchanger to keep their temperature between 41.5 degrees C and 42.0 degrees C for three hours. The patients were administered angiotensin to maintain tumor blood flow. Lactated Ringer's solution was administered at the rate of 10 to 15 ml.kg-1.hr-1 for five hours. Plasma cortisol levels decreased significantly to about one third of the control value after heating and the levels recovered to the control value after cooling. Plasma norepinephrine level increased significantly to about 7 to 9 times the control value following TBH, but this hormonal response was insufficient to reveal marked direct hemodynamic effects. The magnitude of fall in SVR was more significant in spite of the administration of angiotensin. Cardiac index increased significantly to about 2.0 to 2.6 fold of control value, but mean arterial blood pressure (MAP) decreased significantly to about two thirds to four fifths of the control value. Morphine relieved the hormonal response in ACTH and cortisol strongly, but morphine suppressed hemodynamics by decreasing SVR. Neither norepinephrine released from sympathetic nerve endings nor even 50 to 200 ng.kg-1.min-1 of angiotensin administered failed to restore SVR or MAP during hyperthermia. 相似文献
17.
Roberto Civitelli M.D. Eturo Ogata Louis V. Avioli Gary Stein Samuel Edelstein John A. Eisman Yasuho Nishii Hajime Orimo Jane Lian Takuo Fujita Yasufumi Hayashi Shigeaki Kato Tadashi Kobayashi Hirotoshi Morii Rikushi Morita Toshitaka Nakamura Yoshiki Seino Masataka Shiraki Tatsuo Suda Naoyuki Takahashi Hideaki Takahashi Tastuhiko Tanisawa Akifumi Tokita 《Calcified tissue international》1995,57(6):409-414
18.
K. Terayama Syuji Toda Nobuhisa Yonemitsu Norimasa Koike Hajime Sugihara 《Virchows Archiv : an international journal of pathology》1997,431(4):291-295
We describe a rare case of papillary carcinoma with extensive proliferation of stromal cells. The stromal cells were immunocytochemically
positive for vimentin, α-smooth muscle actin and desmin, but negative for cytokeratin, epithelial membrane antigen, S-100,
thyroglobulin and CD34. These results and the ultrastructure of the stromal cells, which exhibited the characteristics of
both fibroblasts and smooth muscle cells, indicated an origin from myofibroblasts. We conclude that myofibroblastic proliferation
may contribute to the stromal response in the slow growth of the papillary carcinoma.
Received: 29 August 1996 / 26 May 1997 相似文献
19.
Susumu Kusunoki Atsuro Chiba Seiji Hitoshi Hajime Takizawa Ichiro Kanazawa 《Muscle & nerve》1995,18(4):409-413
Four of 82 patients with Guillain-Barré syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal-C). Two patients with GBS without mycoplasma infection also had anti-Gal-C antibody, whereas none of the normal or the disease controls had it. As Gal-C is a major glycolipid antigen in myelin, anti-Gal-C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies. Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti-Gal-C antibody. © 1995 John Wiley & Sons, Inc. 相似文献
20.
S Hirooka R Ishihara K Inui Y Yuki E Hoshi M Washio 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(9):696-700
During the last 5 years, 5 cases of traumatic diaphragmatic rupture were surgically treated. These cases were reported and the literature concerning traumatic diaphragmatic hernia in the last one decade in Japan, including 80 cases was studied. The purpose of this study is to discuss the most important early diagnostic tools and to consider the choice of incision and approach. The following two results were gotten. (1) Plain chest X-ray, computed tomography and ultrasonography were the most valuable diagnostic tools. (2) The choice of incision and approach depends on the stage at which the rupture is recognized (early or late), the site of rupture and associate injuries. 相似文献